Professor Edna Hardeman
Tabs
Publications related to this Person
Book Chapters
Kee AJ; Hardeman EC, 2012, 'Thin filament diseases of striated muscle', in Cytoskeleton and Human Disease, Humana Press, Springer, Printforce, The Netherlands, pp. 123 - 140, http://dx.doi.org/10.1007/978-1-61779-788-0_6
Nguyen MA; Hardeman EC, 2008, 'Mouse models for thin filament disease', in Advances in Experimental Medicine and Biology, Springer New York LLC, pp. 66 - 77, http://dx.doi.org/10.1007/978-0-387-84847-1_6
Hardeman E; Arkell R; Brennan K; Dunwoodie S; Esser K; Gordon M; Joya J; Shalhoub C; Sutherland C, 1992, 'Skeletal muscle gene control and transgenic mice', in Kakulas B; Howell J; Roses A (ed.), Duchenne Muscular Dystrophy: Animal Models and Genetic Manipulation, edn. 1, Raven Press Ltd, New York, pp. 237 - 246
Journal articles
Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2022, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, vol. 21, pp. 120 - 128, http://dx.doi.org/10.1038/s41563-021-01087-z
Hardeman EC; Heydecker M; Masedunskas A; Ebrahim S; Weigert R; Gunning PW, 2022, 'Intravital subcellular and single molecule imaging reveals multiple actin filament populations collaborate in the remodelling of the secretory granule membrane', Biophysical Journal, vol. 121, pp. 297a - 298a, http://dx.doi.org/10.1016/j.bpj.2021.11.1268
Xu X; Wang Y; Bryce NS; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents', British Journal of Cancer, vol. 125, pp. 265 - 276, http://dx.doi.org/10.1038/s41416-021-01420-y
Rae J; Ferguson C; Ariotti N; Webb RI; Cheng HH; Mead JL; Riches JD; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Sayre ME; Hardeman EC; Gunning PW; Gambin Y; Hall TE; Parton RG, 2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, vol. 10, http://dx.doi.org/10.7554/ELIFE.64630
Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
Slick R; Tinklenberg J; Meng H; Beatka M; Prom M; Ott E; Montanaro F; Zhang L; Granzier H; Hardeman E; Geurts A; Lawlor M, 2020, 'Proteomic profiling in Nemaline myopathy to identify molecular phenotypes that contribute to disease heterogeneity', NEUROMUSCULAR DISORDERS, vol. 30, pp. S54 - S54, http://dx.doi.org/10.1016/j.nmd.2020.08.030
Janco M; Dedova I; Bryce NS; Hardeman EC; Gunning PW, 2020, 'Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy', Biophysical Reviews, vol. 12, pp. 879 - 885, http://dx.doi.org/10.1007/s12551-020-00720-6
Wang Y; Stear JH; Swain A; Xu X; Bryce NS; Carnell M; Alieva IB; Dugina VB; Cripe TP; Stehn J; Hardeman EC; Gunning PW, 2020, 'Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects', Molecular Cancer Research, vol. 18, pp. 1074 - 1087, http://dx.doi.org/10.1158/1541-7786.MCR-19-1122
Hardeman EC; Bryce NS; Gunning PW, 2020, 'Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms', Seminars in Cell and Developmental Biology, vol. 102, pp. 122 - 131, http://dx.doi.org/10.1016/j.semcdb.2019.10.004
Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Lahti L; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2020, 'Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment', iScience, vol. 23, http://dx.doi.org/10.1016/j.isci.2020.101053
Manstein DJ; Meiring JCM; Hardeman EC; Gunning PW, 2020, 'Actin–tropomyosin distribution in non-muscle cells', Journal of Muscle Research and Cell Motility, vol. 41, pp. 11 - 22, http://dx.doi.org/10.1007/s10974-019-09514-0
Amorim NML; Kee A; Coster ACF; Lucas C; Bould S; Daniel S; Weir JM; Mellett NA; Barbour J; Meikle PJ; Cohn RJ; Turner N; Hardeman EC; Simar D, 2020, 'Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors', Metabolism: clinical and experimental, vol. 103, pp. 154025, http://dx.doi.org/10.1016/j.metabol.2019.154025
Hardeman EC; Gunning PW, 2020, 'Life and death agendas of actin filaments', Nature Materials, vol. 19, pp. 135 - 136, http://dx.doi.org/10.1038/s41563-019-0583-1
Yeola A; Subramanian S; Oliver R; Lucas C; Thoms J; Yan F; Olivier J; Chacon D; Tursky M; Hung T; Power C; Hardy P; Ma D; McCarroll J; Kavallaris M; Hesson L; Beck D; Curtis D; Wong JWH; Hardeman E; Walsh W; Mobbs R; Chandrakanthan V; Pimanda J, 2020, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', , http://dx.doi.org/10.1101/2020.06.04.130872
Rae J; Ferguson C; Ariotti N; Webb R; Cheng H-H; Mead J; Riches J; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce N; Cagigas ML; Fonseka S; Hardeman E; Gunning P; Gambin Y; Hall T; Parton R, 2020, 'APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy', , http://dx.doi.org/10.1101/2020.10.06.328831
Meiring JCM; Bryce NS; Niño JLG; Gabriel A; Tay SS; Hardeman EC; Biro M; Gunning PW, 2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-42977-2
Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG, 2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, vol. 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002
Slick R; Tinklenberg J; Vanden Avond M; Beatka M; Meng H; Seibers E; Geurts A; Granzier H; Hardeman E; Zhang L; Montanaro F; Nowak K; Lawlor M, 2019, 'Proteomic profiling in nemaline myopathy to identify molecular phenotypes', NEUROMUSCULAR DISORDERS, vol. 29, pp. S93 - S93, http://dx.doi.org/10.1016/j.nmd.2019.06.210
Ross JA; Levy Y; Ripolone M; Kolb JS; Turmaine M; Holt M; Lindqvist J; Claeys KG; Weis J; Monforte M; Tasca G; Moggio M; Figeac N; Zammit PS; Jungbluth H; Fiorillo C; Vissing J; Witting N; Granzier H; Zanoteli E; Hardeman EC; Wallgren-Pettersson C; Ochala J, 2019, 'Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy', Acta Neuropathologica, vol. 138, pp. 477 - 495, http://dx.doi.org/10.1007/s00401-019-02034-8
Meiring JCM; Bryce NS; Lastra Cagigas M; Benda A; Whan RM; Ariotti N; Parton RG; Stear JH; Hardeman EC; Gunning PW, 2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of cell science, vol. 132, http://dx.doi.org/10.1242/jcs.228916
Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, vol. 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9
Bryce NS; Hardeman EC; Gunning PW; Lock JG, 2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, vol. 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013
Ebrahim S; Chen D; Weiss M; Malec L; Ng Y; Rebustini I; Krystofiak E; Hu L; Liu J; Masedunskas A; Hardeman E; Gunning P; Kachar B; Weigert R, 2019, 'Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice', Nature Cell Biology, vol. 21, pp. 933 - 939, http://dx.doi.org/10.1038/s41556-019-0365-7
Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-22946-x
Meiring JCM; Bryce NS; Wang Y; Taft MH; Manstein DJ; Liu Lau S; Stear J; Hardeman EC; Gunning PW, 2018, 'Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton', Current Biology, vol. 28, pp. 2331 - 2337.e5, http://dx.doi.org/10.1016/j.cub.2018.05.053
Gunning PW; Hardeman EC, 2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, vol. 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441
Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, vol. 131, http://dx.doi.org/10.1242/jcs.212654
Gunning PW; Hardeman EC, 2018, 'Fundamental differences', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.34477
Siebers E; Tinklenberg J; Meng H; Ayres S; Vanden Avond M; Slick R; Nowake K; Granzier H; Hardeman E; Montanaro F; Lawlor M, 2018, 'CONGENITAL MYOPATHIES: NEMALINE AND TITINOPATHIES', Neuromuscular Disorders, vol. 28, pp. S102 - S103, http://dx.doi.org/10.1016/j.nmd.2018.06.282
Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00421
Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, vol. 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405
Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW; Kloss N; Treutlein H; Zeng J; Alieva IB; Dugina VB; Hardeman EC; Gunning PW; Cripe TP, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, vol. 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873
Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154
Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, vol. 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033
Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'Cover Image, Volume 74, Issue 10', Cytoskeleton, vol. 74, pp. C4 - C4, http://dx.doi.org/10.1002/cm.21413
Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0168203
Akladios B; Mendoza-Reinoso V; Samuel MS; Hardeman EC; Khosrotehrani K; Key B; Beverdam A, 2016, 'Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin in vivo', Journal of Investigative Dermatology, vol. 137, pp. 716 - 726, http://dx.doi.org/10.1016/j.jid.2016.10.029
Liang H; Akladios B; Canales CP; Francis R; Hardeman EH; Beverdam A, 2016, 'CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations', Journal of Visualized Experiments, vol. 2016, http://dx.doi.org/10.3791/54401
Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2801-4
Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; DasGupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', American Journal of Pathology, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008
Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; Dasgupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008
Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028
Lindqvist J; Levy Y; Pati-Alam A; Hardeman EC; Gregorevic P; Ochala J, 2016, 'Modulating myosin restores muscle function in a mouse model of nemaline myopathy', Annals of Neurology, vol. 79, pp. 717 - 725, http://dx.doi.org/10.1002/ana.24619
Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816
Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, vol. 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020
Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342
Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, vol. 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0
Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, vol. 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502
Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, vol. 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282
Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, vol. 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188
Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126214
Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453
Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, vol. 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, vol. 26, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Lindqvist J; Hardeman EC; Ochala J, 2014, 'Sexually dimorphic myofilament function in a mouse model of nemaline myopathy', Archives of Biochemistry and Biophysics, vol. 564, pp. 37 - 42, http://dx.doi.org/10.1016/j.abb.2014.09.011
Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, vol. 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202
Gineste C; Ottenheijm C; Fur YL; Banzet S; Pecchi E; Vilmen C; Cozzone PJ; Koulmann N; Hardeman EC; Bendahan D; Gondin J, 2014, 'Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of Nemaline myopathy', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0109066
Head SI; Houweling PJ; Chan S; Chen G; Hardeman EC, 2014, 'Properties of regenerated mouse extensor digitorum longus muscle following notexin injury', Experimental Physiology, vol. 99, pp. 664 - 674, http://dx.doi.org/10.1113/expphysiol.2013.077289
Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, vol. 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011
Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, vol. 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293
Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kee AJ; Tran L; Yang L; Genel F; Weigert R; Gunning P; Hardeman E, 2013, 'Identification of a novel Golgi-associated actin filament population that is important for maintaining Golgi morphology', MOLECULAR BIOLOGY OF THE CELL, vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, vol. 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287
Lindqvist J; Cheng AJ; Renaud G; Hardeman E; Ochala J, 2013, 'Distinct Underlying Mechanisms of Limb and Respiratory Muscle Fiber Weaknesses in Nemaline Myopathy', Journal of Neuropathology and Experimental Neurology, vol. 72, pp. 472 - 481, http://dx.doi.org/10.1097/NEN.0b013e318293b1cc
Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, vol. 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489
Gineste C; Le FY; Vilmen C; Le TA; Pecchi E; Cozzone PJ; Hardeman EC; Bendahan D; Gondin J, 2013, 'Combined MRI and 31P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism', PLoS ONE, vol. 8, pp. e61517, http://dx.doi.org/10.1371/journal.pone.0061517
Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, vol. 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501
Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Davies KE; Laing NG; Nowak KJ, 2013, 'Cardiac alpha-actin over-expression therapy in dominant ACTA1 disease', Human Molecular Genetics, vol. 22, pp. 1 - 11, http://dx.doi.org/10.1093/hmg/ddt252
Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture', BioArchitecture, vol. 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966
Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan Y-KA; Yeo J-L; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, vol. 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/​jcs.102798
Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation', PLoS ONE, vol. 7, pp. e49283 pg 1 - e49283 pg 10, http://dx.doi.org/10.1371/journal.pone.0049283
Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TY; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.', Neurobiology of Disease, vol. 45, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010
Nguyen MA; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.', Brain, vol. 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274
Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, vol. 142, pp. 387 - 397, http://dx.doi.org/10.1016/j.cell.2010.06.036
Leong GM; Kee AJ; Millard SM; Martel N; Eriksson N; Turner N; Cooney GJ; Hardeman EC; Muscat GE, 2010, 'The Ski proto-oncogene regulates body composition and suppresses lipogenesis.', International journal of obesity, vol. 34, pp. 524 - 536, http://dx.doi.org/10.1038/ijo.2009.265
Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Tay ES; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', The Journal of Biological Chemistry, vol. 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660
Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, vol. 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28
Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, vol. 66, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400
Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, vol. 30, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x
Vlahovich N; Kee AJ; Van der Poel C; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, vol. 20, pp. 400 - 409, http://dx.doi.org/10.1091/mbc.E08-06-0616
MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380
Cowling BS; McGrath MJ; Nguyen MA; Cottle DL; Kee AJ; Brown S; Schessl J; Zou Y; Joya J; Bonnemann CG; Hardeman EC; Mitchell CA, 2008, 'Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy', Journal of Cell Biology, vol. 183, pp. 1033 - 1048, http://dx.doi.org/10.1083/jcb.200804077
Kee AJ; Hardeman EC, 2008, 'Tropomyosins in skeletal muscle diseases', Advances in Experimental Medicine and Biology, vol. 644, pp. 143 - 154, http://dx.doi.org/10.1007/978-0-387-85766-4_12
Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJ; Hardeman EC; Wieczorek DF; O'Neill GM; Gunning PW, 2008, 'Divergent regulation of the sarcomere and the cytoskeleton', The Journal of Biological Chemistry, vol. 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.M704392200
Vlahovich N; Schevzov G; Nair-Shaliker V; Ilkovski B; Artap ST; Kee AJ; North KN; Gunning PW; Hardeman EC, 2008, 'Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle', Cell Motility and the Cytoskeleton, vol. 65, pp. 73 - 85, http://dx.doi.org/10.1002/cm.20245
Chang AC; Hook J; Lemckert FA; McDonald M; Nguyen MA; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, vol. 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219
Gunning PW; O'Neill G; Hardeman EC, 2008, 'Tropomyosin-based regulation of the actin cytoskeleton in time and space', Physiological Reviews, vol. 88, pp. 1 - 35, http://dx.doi.org/10.1152/physrev.00001.2007
Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, vol. 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008
MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y; Hardeman EC; Gunning PW; Easteal S; Yang N; North KN, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, vol. 39, pp. 1261 - 1265, http://dx.doi.org/10.1038/ng2122
Domazetovska A; Ilkovski B; Cooper ST; Ghoddusi M; Hardeman EC; Minamide LS; Gunning PW; Bamburg JR; North K, 2007, 'Mechanisms underlying intranuclear rod formation', Brain, vol. 130, pp. 3275 - 3284, http://dx.doi.org/10.1093/brain/awm247
Chen W; Ruell PA; Ghoddusi M; Kee A; Hardeman EC; Hoffman KM; Thompson MW, 2007, 'Ultrastructural changes and SR Ca2+ regulation in red vastus muscle following eccentric exercise in the rat', Experimental Physiology, vol. 92, pp. 437 - 447, http://dx.doi.org/10.1113/expphysiol.2006.036442
Issa LL; Palmer SJ; Guven KL; Santucci N; Hodgson VRM; Popovic K; Joya JE; Hardeman EC, 2006, 'MusTRD can regulate postnatal fiber-specific expression', Developmental Biology, vol. 293, pp. 104 - 115, http://dx.doi.org/10.1016/j.ydbio.2006.01.019
Butler TL; Au CG; Yang B; Egan JR; Tan YM; Hardeman EC; North KN; Verkman AS; Winlaw DS, 2006, 'Cardiac aquaporin expression in humans, rats, and mice', American Journal of Physiology - Heart and Circulatory Physiology, vol. 291, pp. H705 - H713, http://dx.doi.org/10.1152/ajpheart.00090.2006
Sanoudou D; Corbett MA; Han M; Ghoddusi M; Nguyen MA; Vlahovich N; Hardeman EC; Beggs AH, 2006, 'Skeletal muscle repair in a mouse model of nemaline myopathy', Human Molecular Genetics, vol. 15, pp. 2603 - 2612, http://dx.doi.org/10.1093/hmg/ddl186
McGrath MJ; Cottle DL; Nguyen MA; Coghill ID; Robinson PA; Holdsworth M; Cowling BS; Hardeman EC; Mitchell CA; Brown S, 2006, 'Four and a half LIM protein 1 binds myosin binding protein C and regulates myosin filament formation and sarcomere assembly', The Journal of Biological Chemistry, vol. 281, pp. 7666 - 7683, http://dx.doi.org/10.1074/jbc.M512552200
Vlahovich N; Elmir S; Schevzov G; Kee A; Gunning P; Hardeman E, 2005, 'Non-muscle tropomyosins define functionally distinct microfilament populations in developing skeletal muscle', MECHANISMS OF DEVELOPMENT, vol. 122, pp. S49 - S49, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CBF; Langdon WY; Walder K; Murphy MA; Bowtell DDL; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'Erratum: c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action (Journal of Clinical Investigation (2004) 114 (1326-1333) (doi:10.1172/JCI200421480))', Journal of Clinical Investigation, vol. 115, pp. 476, http://dx.doi.org/10.1172/JCI200521480C1
Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CB; Langdon WY; Walder K; Murphy MA; Bowtell DL; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action', The Journal of Clinical Investigation, vol. 114, pp. 1326 - 1333, http://dx.doi.org/10.1172/JCI200421480
Schevzov G; Bryce NS; Almonte-Baldonado R; Joya J; Lin JJ; Hardeman E; Weinberger R; Gunning P, 2005, 'Specific features of neuronal size and shape are regulated by tropomyosin isoforms.', Molecular Biology of the Cell, vol. 16, pp. 3425 - 3437, http://dx.doi.org/10.1091/mbc.E04-10-0951
Gunning PW; Schevzov G; Kee AJ; Hardeman EC, 2005, 'Tropomyosin isoforms: divining rods for actin cytoskeleton function', Trends in Cell Biology, vol. 15, pp. 333 - 341, http://dx.doi.org/10.1016/j.tcb.2005.04.007
Corbett MA; Akkari AP; Domazetovska A; Cooper ST; North K; Laing NG; Gunning PW; Hardeman EC, 2005, 'An alphatropomyosin mutation alters dimer preference in nemaline myopathy', Annals of Neurology, vol. 57, pp. 42 - 49, http://dx.doi.org/10.1002/ana.20305
Molero JC; Jensen T; Withers P; Couzens M; Herzog H; Thien C; Langdon WY; Walder K; Murphy M; Bowtell D; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'Erratum: c-Cbl-deficient mice have reduced adiposity, higher energy expenditure,and improved peripheral insulin action (vol 114, pg 1326, 2004)', Journal of Clinical Investigation, vol. 115, pp. 476 - 476, http://dx.doi.org/10.1172/JCI21480C1
Kee AJ; Schevzov G; Nair-shaliker V; Robinson C; Vrhovski B; Ghoddusi M; Qiu M; Lin JJ; Weinberger R; Gunning P; Hardeman E, 2004, 'Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.', Journal of Cell Biology, vol. 166, pp. 685 - 696, http://dx.doi.org/10.1083/jcb.200406181
Nair-Shalliker V; Kee A; Lucas C; Joya JE; Hoh JF; Hardeman EC, 2004, 'Myofiber adaptational response to exercise in a mouse model of nemaline myopathy', Muscle and Nerve, vol. 30, pp. 470 - 480, http://dx.doi.org/10.1002/mus.20138
Cooper ST; Maxwell AL; Kizana E; Ghoddusi M; Hardeman EC; Alexander IE; Allen DG; North KN, 2004, 'C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression', Cell Motility and the Cytoskeleton, vol. 58, pp. 200 - 211, http://dx.doi.org/10.1002/cm.20010
Joya JE; Kee A; Nair-Shalliker V; Ghoddusi M; Nguyen MAT; Luther P; Hardeman EC, 2004, 'Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism', Human Molecular Genetics, vol. 13, pp. 2633 - 2645, http://dx.doi.org/10.1093/hmg/ddh285
Bryce N; Schevzov G; Ferguson V; Percival J; Lin JJ; Matsumura F; Bamburg J; Jeffrey P; Hardeman E; Gunning P; Weinberger R, 2003, 'Specification of actin filament function and molecular composition by tropomyosin isoforms.', Molecular Biology of the Cell, vol. 14, pp. 1002 - 1016, http://dx.doi.org/10.1091/mbc.E02-04-0244
Tay ES; Guven KL; Subramaniam N; Polly P; Issa LL; Gunning PW; Hardeman EC, 2003, 'Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity', Biochemical Journal, vol. 374, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20030189
Polly P; Haddadi L; Issa LL; Subramaniam N; Palmer S; Tay ES; Hardeman EC, 2003, 'hMusTRD1α1 Represses MEF2 Activation of the Troponin I Slow Enhancer', The Journal of Biological Chemistry, vol. 278, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200
de Haan A; van der Vliet MR; Gommans IM; Hardeman EC; van Engelen BG, 2002, 'Skeletal muscle of mice with a mutation in slow α-tropomyosin is weaker at lower lengths', Neuromuscular Disorders, vol. 12, pp. 952 - 957, http://dx.doi.org/10.1016/S0960-8966(02)00138-4
De Iongh RU; Lovicu FJ; Overbeek PA; Schneider MD; Joya JE; Hardeman E; McAvoy JW, 2001, 'Requirement for TGFβ receptor signaling during terminal lens fiber differentiation', Development, vol. 128, pp. 3995 - 4010
Gunning P; Ferguson V; Brennan KJ; Hardeman EC, 2001, 'Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle', Journal of Cell Science, vol. 114, pp. 513 - 524
Corbett MA; Robinson CS; Yang N; Joya JE; Stewart AW; Schnell C; Gunning PW; North KN; Hardeman E, 2001, 'A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy', Human Molecular Genetics, vol. 10, pp. 317 - 328
Ilkovski B; Cooper ST; Nowak K; Ryan MM; Yang N; Schnell C; Durling HJ; Roddick LG; Wilkinson I; Kornberg AJ; Collins KJ; Wallace G; Gunning PW; Hardeman E; North K, 2001, 'Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene', American Journal of Human Genetics, vol. 68, pp. 1333 - 1343, http://dx.doi.org/10.1086/320605
O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 2000, 'Erratum: Identification of a novel slow-muscle-fiber enhancer binding protein, musTRD1 (Molecular and Cellular Biology (1998) 18:11 (6641-6652))', Molecular and Cellular Biology, vol. 20, pp. 5361, http://dx.doi.org/10.1128/MCB.20.14.5361-5361.2000
Wadhwa R; Sugihara T; Yoshida A; Duncan EL; Hardeman E; Nomura H; Reddel RR; Kaul SC, 1999, 'Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53', The Journal of Biological Chemistry, vol. 274, pp. 14948 - 14955, http://dx.doi.org/10.1074/jbc.274.21.14948
Gunning P; Weinberger R; Jeffrey P; Hardeman E, 1998, 'Isoform sorting and the creation of intracellular compartments', Annual Review of Cell and Developmental Biology, vol. 14, pp. 339 - 372, http://dx.doi.org/10.1146/annurev.cellbio.14.1.339
Gunning P; Hardeman E; Jeffrey P; Weinberger R, 1998, 'Creating intracellular structural domains: spatial segregation of actin and tropomyosin isoforms in neurons', BioEssays, vol. 20, pp. 892 - 900, http://dx.doi.org/10.1002/(SICI)1521-1878(199811)20:11<892::AID-BIES4>3.0.CO;2-D
O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 1998, 'Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1', Molecular and Cellular Biology, vol. 18, pp. 6641 - 6652, http://dx.doi.org/10.1128/MCB.18.11.6641
Criswell DS; Hodgson VR; Hardeman EC; Booth FW, 1998, 'Nerve-responsive troponin I slow promoter does not respond to unloading', Journal of Applied Physiology, vol. 84, pp. 1083 - 1087
Newlands S; Levitt LK; Robinson CS; Karpf AB; Hodgson VR; Wade RP; Hardeman EC, 1998, 'Transcription occurs in pulses in muscle fibers', Genes and Development, vol. 12, pp. 2748 - 2758, http://dx.doi.org/10.1101/gad.12.17.2748
Criswell DS; Hodgson VRM; Hardeman EC; Booth FW, 1998, 'THE NERVE-RESPONSIVE TROPONIN-I SLOW PROMOTER DOES NOT RESPOND TO UNLOADING', Medicine & Science in Sports & Exercise, vol. 30, pp. 143 - 143, http://dx.doi.org/10.1097/00005768-199805001-00810
Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273, http://dx.doi.org/10.1152/ajpcell.1997.273.6.c1801
Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273, pp. C1801 - C1810
Coumans JV; Yeoh T; Seeto RK; Keogh A; Brennan K; Gunning P; Hardeman E; Dos Remedios CG, 1997, 'Variations in relative mRNA levels of actin and myosin heavy chains do not produce corresponding differences in their proteins in the adult human heart', Journal of Molecular and Cellular Cardiology, vol. 29, pp. 895 - 905, http://dx.doi.org/10.1006/jmcc.1996.0317
Gunning P; Ferguson V; Brennan K; Hardeman E, 1997, 'Impact of α-Skeletal Actin but not α-Cardiac Actin on Myoblast Morphology', Cell Structure and Function, vol. 22, pp. 173 - 179, http://dx.doi.org/10.1247/csf.22.173
Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor alpha-sarcomeric actins in postnatal muscle.', Am J Physiol, vol. 273, pp. C1801 - C1810, http://dx.doi.org/10.1152/ajpcell.1997.273.6.C1801
Dos Remedios CG; Berry DA; Carter LK; Coumans JV; Heinke MY; Kiessling PC; Seeto RK; Thorvaldson T; Trahair T; Yeoh T; Gunning PW; Hardeman E; Humphery-Smith I; Naidoo D; Keogh A, 1996, 'Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels', Electrophoresis, vol. 17, pp. 235 - 238, http://dx.doi.org/10.1002/elps.1150170140
Corin SJ; Levitt LK; O'Mahoney JV; Joya JE; Hardeman EC; Wade R, 1995, 'Delineation of a slow-twitch-myofiber-specific transcriptional element by using in vivo somatic gene transfer', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, pp. 6185 - 6189, http://dx.doi.org/10.1073/pnas.92.13.6185
ESSER K; BRENNAN K; HARDEMAN E, 1995, 'WEIGHT-BEARING ACTIVITY, IN ADDITION TO INNERVATION, IS NECESSARY FOR THE ACQUISITION OF A SLOW CONTRACTILE PROTEIN MESSENGER-RNA PROFILE DURING REGENERATION', FASEB JOURNAL, vol. 9, pp. A655 - A655, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QM40600178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
ESSER KA; HARDEMAN EC, 1995, 'CHANGES IN CONTRACTILE PROTEIN MESSENGER-RNA ACCUMULATION IN RESPONSE TO SPACEFLIGHT', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, vol. 268, pp. C466 - C471, http://dx.doi.org/10.1152/ajpcell.1995.268.2.C466
Zhu L; Lyons GE; Juhasz O; Joya JE; Hardeman EC; Wade R, 1995, 'Developmental Regulation of Troponin I Isoform Genes in Striated Muscles of Transgenic Mice', Developmental Biology, vol. 169, pp. 487 - 503, http://dx.doi.org/10.1006/dbio.1995.1163
Levitt LK; O'mahoney JV; Brennan KJ; Joya JE; Zhu L; Wade RP; Hardeman EC, 1995, 'The Human Troponin I Slow Promoter Directs Slow Fiber-Specific Expression in Transgenic Mice', DNA and Cell Biology, vol. 14, pp. 599 - 607, http://dx.doi.org/10.1089/dna.1995.14.599
Esser KA; Hardeman EC, 1995, 'Changes in contractile protein mRNA accumulation in response to spaceflight', American Journal of Physiology - Cell Physiology, vol. 268, http://dx.doi.org/10.1152/ajpcell.1995.268.2.c466
Dunwoodie SL; Joya JE; Arkell RM; Hardeman EC, 1994, 'Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle', Journal of Biological Chemistry, vol. 269, pp. 12212 - 12219
Esser K; Fauteck S; Kandarlan S; Hardeman E, 1994, '529 MYOSIN HEAVY CHAIN PROTEIN AND mRNA EXPRESSION IN RESPONSE TO SPACEFLIGHT', Medicine & Science in Sports & Exercise, vol. 26, pp. S94 - S94, http://dx.doi.org/10.1249/00005768-199405001-00530
Esser K; Gunning P; Hardeman E, 1993, 'Nerve-dependent and -independent patterns of mRNA expression in regenerating skeletal muscle', Developmental Biology, vol. 159, pp. 173 - 183, http://dx.doi.org/10.1006/dbio.1993.1231
Sutherland CJ; Esser KA; Elsom VL; Gordon ML; Hardeman EC, 1993, 'Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation', Developmental Dynamics, vol. 196, pp. 25 - 36, http://dx.doi.org/10.1002/aja.1001960104
Brennan KJ; Hardeman EC, 1993, 'Quantitative analysis of the human α-skeletal actin gene in transgenic mice', Journal of Biological Chemistry, vol. 268, pp. 719 - 725
Hailstones D; Barton P; Chan-Thomas P; Sasse S; Sutherland C; Hardeman E; Gunning P, 1992, 'Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development', Journal of Biological Chemistry, vol. 267, pp. 23295 - 23300
CORIN S, 1992, 'In vitro and in vivo expression analysis of the human slow skeletal troponin I gene', Journal of Molecular and Cellular Cardiology, vol. 24, pp. S39 - S39, http://dx.doi.org/10.1016/0022-2828(92)92973-g
Sutherland CJ; Elsom VL; Gordon ML; Dunwoodie SL; Hardeman EC, 1991, 'Coordination of skeletal muscle gene expression occurs late in mammalian development', Developmental Biology, vol. 146, pp. 167 - 178, http://dx.doi.org/10.1016/0012-1606(91)90457-E
Gunning P; Hardeman E, 1991, 'Multiple mechanisms regulate muscle fiber diversity', The FASEB Journal, vol. 5, pp. 3064 - 3071
Gunning P; Gordon M; Wade R; Gahlmann R; Lin CS; Hardeman E, 1990, 'Differential control of tropomyosin mRNA levels during myogenesis suggests the existence of an isoform competition-autoregulatory compensation control mechanism', Developmental Biology, vol. 138, pp. 443 - 453, http://dx.doi.org/10.1016/0012-1606(90)90210-A
Wade R; Sutherland C; Gahlmann R; Kedes L; Hardeman E; Gunning P, 1990, 'Regulation of contractile protein gene family mRNA pool sizes during myogenesis', Developmental Biology, vol. 142, pp. 270 - 282, http://dx.doi.org/10.1016/0012-1606(90)90348-M
Webster KA; Gunning P; Hardeman E; Wallace DC; Kedes L, 1990, 'Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts', Journal of Cellular Physiology, vol. 142, pp. 566 - 573, http://dx.doi.org/10.1002/jcp.1041420316
Hardeman EC; Minty A; Benton-Vosman P; Kedes L; Blau HM, 1988, 'In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function', Journal of Cell Biology, vol. 106, pp. 1027 - 1034, http://dx.doi.org/10.1083/jcb.106.4.1027
Gunning P; Hardeman E; Wade R; Ponte P; Bains W; Blau HM; Kedes L, 1987, 'Differential patterns of transcript accumulation during human myogenesis.', Molecular and cellular biology, vol. 7, pp. 4100 - 4114, http://dx.doi.org/10.1128/MCB.7.11.4100
WADE R; GUNNING P; HARDEMAN E; GAHLMANN R; BLAU H; KEDES L, 1987, 'DISTINCTIVE PATTERNS OF MUSCLE-SPECIFIC MESSENGER-RNA ACCUMULATION DURING HUMAN MYOGENESIS', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 96 - 96, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987G822600243&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Gunning P; Hardeman E; Wade R; Ponte P; Bains W; Blau HM; Kedes L, 1987, 'Differential patterns of transcript accumulation during human myogenesis', Molecular and Cellular Biology, vol. 7, pp. 4100 - 4114, http://dx.doi.org/10.1128/mcb.7.11.4100-4114.1987
Hardeman EC; Chiu CP; Minty A; Blau HM, 1986, 'The pattern of actin expression in human fibroblast × mouse muscle heterokaryons suggests that human muscle regulatory factors are produced', Cell, vol. 47, pp. 123 - 130, http://dx.doi.org/10.1016/0092-8674(86)90373-9
KEDES L; MINTY A; WADE R; GUNNING P; HARDEMAN E; BLAU H; BENTONVOSMAN P; BOXER L; ERBA H; FELDMAN D; GAHLMANN R; MIWA T; MUSCAT G; TAYLOR A, 1986, 'MULTILEVEL REGULATION OF GENE-EXPRESSION IN HUMAN MYOGENESIS - DISSOCIATION OF FACTORS RESPONSIBLE FOR MODULATION AND ACTIVATION AND EVIDENCE FOR NON-COORDINATE EXPRESSION', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 16 - 16, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986A664400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Skalnik DG; Brown DA; Brown PC; Friedman RL; Hardeman EC; Schimke RT; Simoni RD, 1985, 'Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines', Journal of Biological Chemistry, vol. 260, pp. 1991 - 1994
Garrison JC; Hardeman E; Wade R; Kedes L; Gunning P, 1985, 'Isolation of full-length cDNAs encoding abundant adult human skeletal muscle mRNAs', Gene, vol. 38, pp. 177 - 188, http://dx.doi.org/10.1016/0378-1119(85)90216-1
Blau HM; Pavlath GK; Hardeman EC; Chiu CP; Silberstein L; Webster SG; Miller SC; Webster C, 1985, 'Plasticity of the differentiated state', Science, vol. 230, pp. 758 - 766, http://dx.doi.org/10.1126/science.2414846
Hardeman EC; Endo A; Simoni RD, 1984, 'Effects of compactin on the levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase in compactin-resistant C100 and wild-type cells', Archives of Biochemistry and Biophysics, vol. 232, pp. 549 - 561, http://dx.doi.org/10.1016/0003-9861(84)90572-1
CHIU CP; HARDEMAN EC; GUNNING P; BLAU HM, 1984, 'TRANSCRIPTIONAL ACTIVATION OF SARCOMERIC ACTINS IN MUSCLE X NONMUSCLE HETEROKARYONS', JOURNAL OF CELL BIOLOGY, vol. 99, pp. A346 - A346, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TM94901278&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Rine J; Hansen W; Hardeman E; Davis RW, 1983, 'Targeted selection of recombinant clones through gene dosage effects', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 6750 - 6754, http://dx.doi.org/10.1073/pnas.80.22.6750
Hardeman EC; Jenke HS; Simoni RD, 1983, 'Overproduction of a M(r) 92,000 protomer of 3 hydroxy 3 methylglutaryl coenzyme A reductase in compactin-resistant C100 cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 1516 - 1520, http://dx.doi.org/10.1073/pnas.80.6.1516
Ryan J; Hardeman EC; Endo A; Simoni RD, 1981, 'Isolation and characterization of cells resistant to ML236B (Compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase', Journal of Biological Chemistry, vol. 256, pp. 6762 - 6768
Brusilow WSA; Gunsalus RP; Hardeman EC, 1981, 'In vitro synthesis of the F
Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG, 'The Limits of Phenotypic Plasticity in the Actin Cytoskeleton Revealed by Unbiased Chemical Perturbation', SSRN Electronic Journal, http://dx.doi.org/10.2139/ssrn.3299445
Conference Papers
Xu X; Wang Y; Bryce N; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Abstract 1045: Combined targeting of actin/tropomyosin and microtubules underlies a potential treatment strategy of epithelial ovarian cancer with cell-cycle dependent synergy', in Cancer Research, American Association for Cancer Research (AACR), pp. 1045 - 1045, presented at Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA, http://dx.doi.org/10.1158/1538-7445.am2021-1045
Xu X; Wang Y; Bryce N; Tang K; Meagher NS; Kang EY; Kelemen LE; Kobel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Combined targeting of actin/tropomyosin and microtubules underlies a potential treatment strategy of epithelial ovarian cancer with cell-cycle dependent synergy.', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000680263503257&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Gunning P; Wang Y; Stear JH; Swain A; Xu X; Bryce N; Alieva IB; Dugina VB; Cripe T; Stehn J; Hardeman EC, 2020, 'Anti-tropomyosin drugs prevent the rescue of vincristine-induced mitotic spindle defects', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-5817
Meiring J; Bryce NS; Hardeman EC; Gunning PW, 2016, 'Human cells contain enough tropomyosin to saturate all actin filaments', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CA, San Francisco, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), CA, San Francisco, 03 December 2016 - 07 December 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396046900904&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kee AJ; Masedunskas A; Lucas CA; Han W; Gunning PW; Hardeman EC, 2015, 'Measuring GLUT4 vesicle exocytosis using intracellular intravital microscopy.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Tinklenberg J; Meng H; Yang L; Hardeman E; Pearsall S; Fitts R; Lawlor M, 2014, 'Treatment with ActRIIB-mFc Improves Lifespan, Behavior and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy', in JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, OR, Portland, pp. 614 - 614, presented at 90th Annual Meeting of the American-Association-of-Neuropathologists-Inc, OR, Portland, 12 June 2014 - 15 June 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336732100120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Laing NG; Nowak KJ, 2012, 'Efficacy of cardiac actin over-expression therapy for ACTA1 disease seems mutation specific', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, AUSTRALIA, Perth, pp. 839 - 839, presented at 17th International Congress of the World-Muscle-Society (WMS), AUSTRALIA, Perth, 09 October 2012 - 13 October 2012, http://dx.doi.org/10.1016/j.nmd.2012.06.125
Hardeman EC; Darhed HA; Lee ASJ; Chen G; Shah J; Joya JE; Gunning PW, 2012, 'BLOOD BORNE AGENTS RESCUE REGENERATION IMPAIRED MUSCLE', in WOUND REPAIR AND REGENERATION, WILEY-BLACKWELL, pp. A59 - A59, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308945000025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Butler T; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in EXPERIMENTAL DERMATOLOGY, WILEY-BLACKWELL, GERMANY, Marburg, pp. e43 - e43, presented at 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), GERMANY, Marburg, 01 March 2012 - 03 March 2012, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300931700252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kee AJ; Lucas CA; Yang L; Szokolai RC; Martel N; Leong GM; Muscat GE; Hughes W; Cooney G; James DE; Gunning PW; Hardeman EC, 2012, 'The actin regulatory protein Tropomyosin 5NM1 regulates glucose uptake and GLUT4 trafficking in the mouse.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601218&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Kee A; Lucas C; Szokolai R; Yang L; Martel N; Leong G; Muscat G; Hughes W; James D; Gunning P; Hardeman E, 2011, 'A novel actin filament class that regulates glucose uptake and GLUT4 trafficking', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CO, Denver, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), CO, Denver, 03 December 2011 - 07 December 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505500204&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Curthoys N; Freittag H; Connor A; Desouza M; Hardeman E; Gunning P; Schevzov G; Fath T, 2011, 'Tropomyosins induce neurite formation in B35 neuroblastoma cells and control neurite branching', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CO, Denver, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), CO, Denver, 03 December 2011 - 07 December 2011, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505503094&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Butler T; Hill TA; McCluskey A; Palmer S; Hardeman EC; Winlaw D; Weninger W; Cripe TP; Gunning P, 2011, 'Abstract A178: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. A178 - A178, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA, http://dx.doi.org/10.1158/1535-7163.targ-11-a178
Stehn J; Schevzov G; Bonello T; McCluskey A; Haass N; Palmer S; Hardeman E; Allanson M; Reeve V; Gunning P, 2010, 'Tropomyosin Tm5NM1: A novel target for cancer therapy', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, GERMANY, Berlin, pp. 107 - 107, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, GERMANY, Berlin, 16 November 2010 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)72041-3
Macarthur D; Yang N; Seto J; Raftery J; Kee A; Hardeman E; Gunning P; North K, 2006, 'A gene for speed: the ACTN3 R577X polymorphism influences muscle performance', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, TURKEY, Istanbul, pp. S59 - S59, presented at 11th International Congress on Neuromuscular Diseases, TURKEY, Istanbul, 02 July 2006 - 07 July 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Domazetovska A; Ilkovski B; Cooper S; Valova V; Lemckert F; Hook J; Hardeman E; Robinson P; Yang N; Gunning P; North K, 2006, 'Unravelling the thin filament: mechanisms of weakness in inherited muscle disease', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, TURKEY, Istanbul, pp. S60 - S61, presented at 11th International Congress on Neuromuscular Diseases, TURKEY, Istanbul, 02 July 2006 - 07 July 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Yang N; MacArthur DG; Kee AJ; Kettle E; Hardeman EC; Lemckert F; Hook J; Gunning PW; North KN, 2006, 'An alpha -actinin-3 Knockout Mouse Suffers Increased Sarcomeric Damage from Eccentric Exercise', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, pp. S123 - S124, http://dx.doi.org/10.1249/00005768-200605001-01445
Schevzov G; Vrhovski B; Bryce NS; Elmir S; Qiu M; Yang N; Verrills NM; Kavallaris M; Puttur F; Hardeman E; Gunning P, 2004, 'Tropomyosin antibodies identify functionally distinct populations of actin filaments', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, DC, Washington, pp. 143A - 143A, presented at Annual Meeting of the American-Society-for-Cell-Biology, DC, Washington, 04 December 2004 - 08 December 2004, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224648801136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Hardeman EC; Nguyen MA; Corbett MA; Ghoddusi M; Joya JE; Gunning PW; North KN, 2003, 'A mouse model for severe actin nemaline myopathy', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, HUNGARY, SZEGED, pp. 620 - 620, presented at 8th International Congress of the World-Muscle-Society, HUNGARY, SZEGED, 03 September 2003 - 06 September 2003, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000185007600028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Posters
Hardeman EC; Kee AJ; Lucas CA; Chagan J; Gunning PW, 2016, 'Metabolic impact of targeting the tropomyosin/actin cytoskeleton to treat cancer', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, CA, San Francisco, Vol. 27, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), CA, San Francisco, 03 December 2016 - 07 December 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396046900905&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348705376&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Presentations
Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Jalilian I; Schevzov G; Fath T; Heu C; Bischof L; Vindin H; Stehn JR; Tate MK; Hardeman EC; Gunning PW, 2014, 'Determining the impact of the actin cytoskeleton on the mechanical properties of cells.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Philadelphia, PA, Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094106093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Hardeman EC; Yang L; Kee AJ; Polishchuk E; Polishchuk R; Pleines I; Kile B; Weigert R; Gunning PW, 2014, 'A novel actin filament population defined by the tropomyosin Tm4 regulates ER-to-Golgi trafficking.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 25, presented at ASCB/IFCB Meeting, PA, Philadelphia, 06 December 2014 - 10 December 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094104105&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Jalilian I; Schevzov G; Fath T; Heu C; Bischof L; Vindin H; Stehn JR; Tate MK; Hardeman EC; Gunning PW, 2014, 'Determining the impact of the actin cytoskeleton on the mechanical properties of cells', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Philadelphia, PA, Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094106265&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Conference Abstracts
Wang Y; Swain A; Stear JH; Bryce NS; Dugina VB; Alieva IB; Cripe TP; Stehn JR; Hardeman EC; Gunning PW, 2017, 'Synergy between anti-tropomyosin and anti-microtubule drugs reveals an interaction between actin and microtubule networks.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 28, presented at Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO), PA, Philadelphia, 02 December 2017 - 06 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426664301293&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Meiring JC; Bryce NS; Stear JH; Hardeman EC; Gunning PW, 2017, 'The tropomyosin isoform composition of cellular actin filaments is not a simple function of relative isoform abundance.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, PA, Philadelphia, Vol. 28, presented at Annual Joint Meeting of the American-Society-for-Cell-Biology and the European-Molecular-Biology-Organization (ASCB/EMBO), PA, Philadelphia, 02 December 2017 - 06 December 2017, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426664301286&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Hardeman E; Cohn RJ; Barres R; Simar D, 2015, 'Radiation-induced metabolic complications: potential role for the microbiota', in Radiation-induced metabolic complications: potential role for the microbiota, Nutrient & Metabolite Sensing, Copenhagen, Denmark, presented at Nutrient & Metabolite Sensing, Copenhagen, Denmark, 01 November 2015 - 05 November 2015
Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Cohn R; Hardeman E; Barres R; Simar D, (eds.), 2015, 'Metabolic complications in cancer survivors: role of adipose tissue dysfunction', in Metabolic complications in cancer survivors: role of adipose tissue dysfunction, Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, presented at Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, 09 February 2015 - 13 February 2015
Segueira VB; Stehn JR; Haass N; Bonello T; Guven K; Desouza M; Schevzov G; Kottyan G; McCluskey A; Bischof L; Palmer S; Hardeman EC; Allanson M; Reeve V; Weninger W; Cripe TP; Gunning P, 2012, 'Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-5230
Stehn JR; Haass NK; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Han MH; Hill TA; McCluskey A; Palmer S; Hardeman EC; Weninger W; Cripe TR; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1827
Preprints
Kokkinos J; Sharbeen G; Ignacio RMC; Pandzic E; Youkhana J; Boyer C; Haghighi KS; Gunawarman M; Goldstein D; Gebski V; Pajic M; Pitiyarachchi O; Davis ME; Schulstad G; Arkell OSM; Kopecky C; Gonzales-Aloy E; Erkan M; Morton JP; Kavallaris M; Gunning PW; Hardeman EC; Johns A; Gill AJ; Whan RM; Mawson A; McCarroll JA; Phillips PA, 2022, βIII-Tubulin is a Brake on Extrinsic Cell-Death in Pancreatic Cancer, http://dx.doi.org/10.1101/2022.09.29.510034
Zhao X; Alibhai D; Walsh T; Tarassova N; Birol S; Williams C; Neil C; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Hers I; Ghevaert C; Poole A, 2021, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.1101/2021.11.01.466743
Zhao X; Alibhai D; Walsh T; Tarassova N; Birol S; Williams C; Neil C; Aitken E; Waller A; Ballester-Beltran J; Gunning P; Hardeman E; Agbani E; Hers I; Ghevaert C; Poole A, 2021, Platelet generation from circulating megakaryocytes is triggered in the lung vasculature, http://dx.doi.org/10.21203/rs.3.rs-690639/v1
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