Professor Edna Hardeman | Brain Sciences UNSW

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University role:

Professor

Phone:

+61 2 9385 3760

Email:

e.hardeman@unsw.edu.au

Professor Edna Hardeman is the Head of the Cellular and Genetic Medicine Unit in the School of Medical Sciences

Research Interests

The Cellular and Genetic Medicine Unit (CGMU) is engaged in a range of research activities that span the basic biology of the actin/tropomyosin cytoskeleton and how it regulates basic cellular functions such as signalling, migration, glucose transport, through to drug development of anti-cytoarchitecture/anti-cancer drugs.

Current research projects are:

Development of anti-tropomyosin drugs as anti-cancer agents
Actin/tropomyosin regulation of GLUT4 trafficking using intracellular intravital imaging
Single molecule intravital imaging of the actin/tropomyosin network during exocytosis

Biography

Prof Hardeman received her doctorate from the Department of Biological Sciences, Stanford University and then took up a postdoctoral fellowship in the Department of Pharmacology, Stanford Medical School. She established her laboratory, the Muscle Development Unit at the Children’s Medical Research Institute in Sydney, and has built an international reputation defining mechanisms of muscle gene regulation, and generating mouse models for human skeletal muscle diseases and trialling therapies as part of an international consortium of the European Neuromuscular Centre. She also established her pre-eminence in the physiology of the actin/tropomyosin cytoskeleton using genetically modified mice. Her research underpins our understanding of the function of the cancer-associated tropomyosin in both normal and childhood cancer tissue.

In 2009 she moved to the University of New South Wales to take up a Research Chair in Anatomy and establish the Cellular and Genetic Medicine Unit. Notable achievements include: developing the human skeletal alpha-actin promoter for skeletal muscle-specific expression in animal models of human disease and for gene therapy, the identification of a novel pulsatory, stochastic mode of gene transcription that contributed a new mechanism to the field of gene regulation and the generation of mouse models for nemaline myopathy and identification of therapies.

As a member of the collaborative team that identified tropomyosins as the gatekeepers of actin filament function she established the physiological role of the cancer associated tropomyosin, Tpm3.1. She has been a member of the team which identified Tpm3.1 as druggable target for cancer therapy and was responsible for demonstrating the safety of using these drugs to treat the childhood cancer, neuroblastoma, in a mouse model. She has expanded this work to the development of additional anti-tropomyosin drugs to treat a range of human disease indications.

Qualifications

BA (Interdisc Arts, Hons) & BSc (Hons) The University of Texas at Austin; PhD Stanford University

Current Appointments & Positions Held

Professor, Head of Cell Biology, Department of Pathology, School of Medical Sciences
Chair, Australian National Health & Medical Research Council (NHMRC) Animal Welfare Committee
Member, Australian National Health & Medical Research Council (NHMRC) Research Quality Steering Committee
Member, Hunter Cell Biology Meeting Committee
Committee Member, Australian and New Zealand Society for Cell and Developmental Biology

Membership in Societies

Australian and New Zealand Society for Cell and Developmental Biology
American Society for Cell Biology
Australian Society for Biochemistry and Molecular Biology
Australian Society for Medical Research

Research keywords
Cell Biology, Cancer, Actin Cytoskeleton, Tropomyosin, Imaging

Research

Research Activity Links:

Development of anti-tropomyosin drugs, anti-cancer drugs

Regulation of glucose uptake by tropomyosins and myosins

Regulation of cell proliferation by the actin cytoskeleton

The role of epigenetic modifications in longterm memory of irradiation in cancer survivors

Field of Research (FOR) Tag:

Biochemistry and Cell Biology

Animal Cell and Molecular Biology

Cancer and related disorders

Socio-economic Objective (SEO) tags:

Inherited Diseases (incl. Gene Therapy)

Cancer and Related Disorders

Child Health

Teaching & Supervision

I am available to supervise:

Yes

Currently supervising:

Nadia Amorim, PhD

Anita Chitsaz, PhD

Maria Lastra Cagigas, Scientia PhD Scholar

Xing Xu, PhD

Marco Heydecker, PhD

Gabriel Moldovan, Honours

Publications related to this Person

Book Chapters

Kee AJ; Hardeman EC, 2012, 'Thin filament diseases of striated muscle', in Cytoskeleton and Human Disease, pp. 123 - 140, http://dx.doi.org/10.1007/978-1-61779-788-0_6

Nguyen MAT; Hardeman EC, 2008, 'Mouse models for thin filament disease', in Advances in Experimental Medicine and Biology, pp. 66 - 77, http://dx.doi.org/10.1007/978-0-387-84847-1_6

Hardeman E; Arkell R; Brennan K; Dunwoodie S; Esser K; Gordon M; Joya J; Shalhoub C; Sutherland C, 1992, 'Skeletal muscle gene control and transgenic mice', in Kakulas B; Howell J; Roses A (ed.), Duchenne Muscular Dystrophy: Animal Models and Genetic Manipulation, edn. 1, Raven Press Ltd, New York, pp. 237 - 246

Journal articles

Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-22946-x

Gunning PW; Hardeman EC, 2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, vol. 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441

Gunning PW; Hardeman EC, 2018, 'Fundamental differences', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.34477

Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00421

Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, vol. 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405

Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022

Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, vol. 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873

Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154

Akladios B; Mendoza-Reinoso V; Samuel MS; Hardeman EC; Khosrotehrani K; Key B; Beverdam A, 2017, 'Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in Mouse Skin In Vivo', Journal of Investigative Dermatology, vol. 137, pp. 716 - 726, http://dx.doi.org/10.1016/j.jid.2016.10.029

Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, vol. 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033

Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0168203

Liang H; Akladios B; Canales CP; Francis R; Hardeman EH; Beverdam A, 2016, 'CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations', Journal of Visualized Experiments, vol. 2016, http://dx.doi.org/10.3791/54401

Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2801-4

Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; DasGupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', American Journal of Pathology, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008

Lindqvist J; Levy Y; Pati-Alam A; Hardeman EC; Gregorevic P; Ochala J, 2016, 'Modulating myosin restores muscle function in a mouse model of nemaline myopathy', Annals of Neurology, vol. 79, pp. 717 - 725, http://dx.doi.org/10.1002/ana.24619

Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342

Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, vol. 26, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, vol. 26, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP, 2015, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, http://dx.doi.org/10.1016/j.celrep.2015.12.020

Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, vol. 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502

Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, http://dx.doi.org/10.1007/s00439-015-1591-0

Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453

Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, vol. 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282

Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126214

Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2015, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, http://dx.doi.org/10.1002/cm.21202

Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams–Beuren Syndrome', European Journal of Human Genetics, vol. 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188

Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, vol. 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293

Lindqvist J; Hardeman EC; Ochala J, 2014, 'Sexually dimorphic myofilament function in a mouse model of nemaline myopathy', Archives of Biochemistry and Biophysics, vol. 564, pp. 37 - 42, http://dx.doi.org/10.1016/j.abb.2014.09.011

Gineste C; Ottenheijm C; Fur YL; Banzet S; Pecchi E; Vilmen C; Cozzone PJ; Koulmann N; Hardeman EC; Bendahan D, 2014, 'Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of Nemaline myopathy', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0109066

Head SI; Houweling PJ; Chan S; Chen G; Hardeman EC, 2014, 'Properties of regenerated mouse extensor digitorum longus muscle following notexin injury', Experimental Physiology, vol. 99, pp. 664 - 674, http://dx.doi.org/10.1113/expphysiol.2013.077289

Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, vol. 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011

Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, vol. 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287

Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Kee AJ; Tran L; Yang L; Genel F; Weigert R; Gunning P; Hardeman E, 2013, 'Identification of a novel Golgi-associated actin filament population that is important for maintaining Golgi morphology', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Lee ASJ; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture.', Bioarchitecture, vol. 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966

Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Davies KE; Laing NG; Nowak KJ, 2013, 'Cardiac α-actin over-expression therapy in dominant ACTA1 disease', Human Molecular Genetics, vol. 22, pp. 3987 - 3997, http://dx.doi.org/10.1093/hmg/ddt252

Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Sequeira VB; Butler TL, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer Research, vol. 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501

Gineste C; Le Fur Y; Vilmen C; Le Troter A; Pecchi E; Cozzone PJ; Hardeman EC; Bendahan D; Gondin J, 2013, 'Combined MRI and ³¹P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy Metabolism', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0061517

Lees JG; Ching YW; Adams DH; Bach CTT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, vol. 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489

Lindqvist J; Cheng AJ; Renaud G; Hardeman EC; Ochala J, 2013, 'Distinct underlying mechanisms of limb and respiratory muscle fiber weaknesses in nemaline myopathy', Journal of Neuropathology and Experimental Neurology, vol. 72, pp. 472 - 481, http://dx.doi.org/10.1097/NEN.0b013e318293b1cc

Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TYC; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations', Neurobiology of Disease, vol. 45, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010

Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 Regulates Protein Partner Interactions and Ubiquitin-Mediated Degradation', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0049283

Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan YKA; Yeo JL; Adams M; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile-element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, vol. 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/jcs.102798

Nguyen MAT; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy', Brain, vol. 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274

Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Taylor KM; Tay ESE; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', Journal of Biological Chemistry, vol. 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660

Leong GM; Kee AJ; Millard SM; Martel N; Eriksson N; Turner N; Cooney GJ; Hardeman EC; Muscat GEO, 2010, 'The Ski proto-oncogene regulates body composition and suppresses lipogenesis', International Journal of Obesity, vol. 34, pp. 524 - 536, http://dx.doi.org/10.1038/ijo.2009.265

Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, vol. 142, pp. 387 - 397

Vlahovich N; Kee AJ; Van Der Poel CD; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, vol. 20, pp. 400 - 409, http://dx.doi.org/10.1091/mbc.E08-06-0616

Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, vol. 30, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x

Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, vol. 66, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400

Lee ASJ; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, vol. 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28

Gunning P; O'Neill G; Hardeman E, 2008, 'Tropomyosin-based regulation of the actin cytoskeleton in time and space', Physiological Reviews, vol. 88, pp. 1 - 35, http://dx.doi.org/10.1152/physrev.00001.2007

Chang ACM; Hook J; Lemckert FA; McDonald MM; Nguyen MAT; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, vol. 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219

Vlahovich N; Schevzov G; Nair-Shaliker V; Ilkovski B; Artap ST; Joya JE; Kee AJ; North KN; Gunning PW; Hardeman EC, 2008, 'Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle', Cell Motility and the Cytoskeleton, vol. 65, pp. 73 - 85, http://dx.doi.org/10.1002/cm.20245

Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJC, 2008, 'Divergent regulation of the sarcomere and the cytoskeleton', Journal of Biological Chemistry, vol. 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.M704392200

Kee AJ; Hardeman EC, 2008, 'Tropomyosins in skeletal muscle diseases', Advances in Experimental Medicine and Biology, vol. 644, pp. 143 - 157, http://dx.doi.org/10.1007/978-0-387-85766-4_12

Cowling BS; McGrath MJ; Nguyen MA; Cottle DL; Kee AJ; Brown S; Schessl J; Zou Y; Joya J; Bönnemann CG, 2008, 'Identifi cation of FHL1 as a regulator of skeletal muscle mass: Implications for human myopathy', Journal of Cell Biology, vol. 183, pp. 1033 - 1048, http://dx.doi.org/10.1083/jcb.200804077

Macarthur DG; Seto JT; Chan S; Quinlan KGR; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between α-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380

Chen W; Ruell PA; Ghoddusi M; Kee A; Hardeman EC; Hoffman KM; Thompson MW, 2007, 'Ultrastructural changes and sarcoplasmic reticulum Ca2+ regulation in red vastus muscle following eccentric exercise in the rat', Experimental Physiology, vol. 92, pp. 437 - 447, http://dx.doi.org/10.1113/expphysiol.2006.036442

Domazetovska A; Ilkovski B; Cooper ST; Ghoddusi M; Hardeman EC; Minamide LS; Gunning PW; Bamburg JR; North KN, 2007, 'Mechanisms underlying intranuclear rod formation', Brain, vol. 130, pp. 3275 - 3284, http://dx.doi.org/10.1093/brain/awm247

MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, vol. 39, pp. 1261 - 1265, http://dx.doi.org/10.1038/ng2122

Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, vol. 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008

McGrath MJ; Cottle DL; Nguyen MA; Dyson JM; Coghill ID; Robinson PA; Holdsworth M; Cowling BS; Hardeman EC; Mitchell CA, 2006, 'Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly', Journal of Biological Chemistry, vol. 281, pp. 7666 - 7683, http://dx.doi.org/10.1074/jbc.M512552200

Sanoudou D; Corbett MA; Han M; Ghoddusi M; Nguyen MAT; Vlahovich N; Hardeman EC; Beggs AH, 2006, 'Skeletal muscle repair in a mouse model of nemaline myopathy', Human Molecular Genetics, vol. 15, pp. 2603 - 2612, http://dx.doi.org/10.1093/hmg/ddl186

Butler TL; Au CG; Yang B; Egan JR; Tan YM; Hardeman EC; North KN; Verkman AS; Winlaw DS, 2006, 'Cardiac aquaporin expression in humans, rats, and mice', American Journal of Physiology - Heart and Circulatory Physiology, vol. 291, http://dx.doi.org/10.1152/ajpheart.00090.2006

Issa LL; Palmer SJ; Guven KL; Santucci N; Hodgson VRM; Popovic K; Joya JE; Hardeman EC, 2006, 'MusTRD can regulate postnatal fiber-specific expression', Developmental Biology, vol. 293, pp. 104 - 115, http://dx.doi.org/10.1016/j.ydbio.2006.01.019

Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CBF; Langdon WY; Walder K; Murphy MA; Bowtell DDL, 2005, 'c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action (vol 114, pg 1326, 2004)', JOURNAL OF CLINICAL INVESTIGATION, vol. 115, pp. 476 - 476, http://dx.doi.org/10.1172/JCI200521480C1

Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CBF; Langdon WY; Walder K; Murphy MA; Bowtell DDL, 2005, 'Erratum: c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action (Journal of Clinical Investigation (2004) 114 (1326-1333) (doi:10.1172/JCI200421', Journal of Clinical Investigation, vol. 115, pp. 476, http://dx.doi.org/10.1172/JCI200521480C1

Vlahovich N; Elmir S; Schevzov G; Kee A; Gunning P; Hardeman E, 2005, 'Non-muscle tropomyosins define functionally distinct microfilament populations in developing skeletal muscle', MECHANISMS OF DEVELOPMENT, vol. 122, pp. S49 - S49, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Corbett MA; Akkari PA; Domazetovska A; Cooper ST; North KN; Laing NG; Gunning PW; Hardeman EC, 2005, 'An αtropomyosin mutation alters dimer preference in nemaline myopathy', Annals of Neurology, vol. 57, pp. 42 - 49, http://dx.doi.org/10.1002/ana.20305

Gunning PW; Schevzov G; Kee AJ; Hardeman EC, 2005, 'Tropomyosin isoforms: Divining rods for actin cytoskeleton function', Trends in Cell Biology, vol. 15, pp. 333 - 341, http://dx.doi.org/10.1016/j.tcb.2005.04.007

Schevzov G; Bryce NS; Almonte-Baldonado R; Joya J; Lin JJC; Hardeman E; Weinberger R; Gunning P, 2005, 'Specific features of neuronal size and shape are regulated by tropomyosin isoforms', Molecular Biology of the Cell, vol. 16, pp. 3425 - 3437, http://dx.doi.org/10.1091/mbc.E04-10-0951

Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CB; Langdon WY; Walder K; Murphy MA; Bowtell DL, 2005, 'c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action', The Journal of Clinical Investigation, vol. 114, pp. 1326 - 1333, http://dx.doi.org/10.1172/JCI200421480

Joya JE; Kee AJ; Nair-Shalliker V; Ghoddusi M; Nguyen MAT; Luther P; Hardeman EC, 2004, 'Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism', Human Molecular Genetics, vol. 13, pp. 2633 - 2645, http://dx.doi.org/10.1093/hmg/ddh285

Cooper ST; Maxwell AL; Kizana E; Ghoddusi M; Hardeman EC; Alexander IE; Allen DG; North KN, 2004, 'C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression', Cell Motility and the Cytoskeleton, vol. 58, pp. 200 - 211, http://dx.doi.org/10.1002/cm.20010

Nair-Shalliker V; Kee AJ; Joya JE; Lucas CA; Hoh JF; Hardeman EC, 2004, 'Myofiber adaptational response to exercise in a mouse model of nemaline myopathy', Muscle and Nerve, vol. 30, pp. 470 - 480, http://dx.doi.org/10.1002/mus.20138

Kee AJ; Schevzov G; Nair-Shalliker V; Robinson CS; Vrhovski B; Ghoddusi M; Qiu MR; Lin JJC; Weinberger R; Gunning PW, 2004, 'Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy', Journal of Cell Biology, vol. 166, pp. 685 - 696, http://dx.doi.org/10.1083/jcb.200406181

Polly P; Haddadi LM; Issa LL; Subramaniam N; Palmer SJ; Tay ESE; Hardeman EC, 2003, 'hMusTRD1α1 represses MEF2 activation of the Troponin I slow enhancer', Journal of Biological Chemistry, vol. 278, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200

Tay ESE; Guven KL; Subramaniam N; Polly P; Issa LL; Gunning PW; Hardeman EC, 2003, 'Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity', Biochemical Journal, vol. 374, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20030189

Bryce NS; Schevzov G; Ferguson V; Percival JM; Lin JJC; Matsumura F; Bamburg JR; Jeffrey PL; Hardeman EC; Gunning P, 2003, 'Specification of actin filament function and molecular composition by tropomyosin isoforms', Molecular Biology of the Cell, vol. 14, pp. 1002 - 1016, http://dx.doi.org/10.1091/mbc.E02-04-0244

De Haan A; Van der Vliet MR; Gommans IMP; Hardeman EC; Van Engelen BGM, 2002, 'Skeletal muscle of mice with a mutation in slow α-tropomyosin is weaker at lower lengths', Neuromuscular Disorders, vol. 12, pp. 952 - 957, http://dx.doi.org/10.1016/S0960-8966(02)00138-4

Ilkovski B; Cooper ST; Nowak K; Ryan MM; Yang N; Schnell C; Durling HJ; Roddick LG; Wilkinson I; Kornberg AJ, 2001, 'Nemaline myopathy caused by mutations in the muscle α-skeletal-actin gene', American Journal of Human Genetics, vol. 68, pp. 1333 - 1343, http://dx.doi.org/10.1086/320605

Corbett MA; Robinson CS; Dunglison GF; Yang N; Joya JE; Stewart AW; Schnell C; Gunning PW; North KN; Hardeman EC, 2001, 'A mutation in α-tropomyosinslowaffects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy', Human Molecular Genetics, vol. 10, pp. 317 - 328

Gunning PW; Ferguson V; Brennan KJ; Hardeman EC, 2001, 'α-Skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle', Journal of Cell Science, vol. 114, pp. 513 - 524

De Iongh RU; Lovicu FJ; Overbeek PA; Schneider MD; Joya JE; Hardeman E; McAvoy JW, 2001, 'Requirement for TGFβ receptor signaling during terminal lens fiber differentiation', Development, vol. 128, pp. 3995 - 4010

O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 2000, 'Erratum: Identification of a novel slow-muscle-fiber enhancer binding protein, musTRD1 (Molecular and Cellular Biology (1998) 18:11 (6641-6652))', Molecular and Cellular Biology, vol. 20, pp. 5361, http://dx.doi.org/10.1128/MCB.20.14.5361-5361.2000

Wadhwa R; Sugihara T; Yoshida A; Duncan EL; Hardeman EC; Nomura H; Reddel RR; Kaul SC, 1999, 'Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53', Journal of Biological Chemistry, vol. 274, pp. 14948 - 14955, http://dx.doi.org/10.1074/jbc.274.21.14948

Newlands S; Levitt LK; Robinson CS; Karpf ABC; Hodgson VRM; Wade RP; Hardeman EC, 1998, 'Transcription occurs in pulses in muscle fibers', Genes and Development, vol. 12, pp. 2748 - 2758, http://dx.doi.org/10.1101/gad.12.17.2748

Criswell DS; Hodgson VRM; Hardeman EC; Booth FW, 1998, 'Nerve-responsive troponin I slow promoter does not respond to unloading', Journal of Applied Physiology, vol. 84, pp. 1083 - 1087

O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 1998, 'Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1', Molecular and Cellular Biology, vol. 18, pp. 6641 - 6652, http://dx.doi.org/10.1128/MCB.18.11.6641

Gunning P; Hardeman E; Jeffrey P; Weinberger R, 1998, 'Creating intracellular structural domains: Spatial segregation of actin and tropomyosin isoforms in neurons', BioEssays, vol. 20, pp. 892 - 900, http://dx.doi.org/10.1002/(SICI)1521-1878(199811)20:11<892::AID-BIES4>3.0.CO;2-D

Gunning P; Weinberger R; Jeffrey P; Hardeman E, 1998, 'Isoform sorting and the creation of intracellular compartments', Annual Review of Cell and Developmental Biology, vol. 14, pp. 339 - 372, http://dx.doi.org/10.1146/annurev.cellbio.14.1.339

Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273

Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor alpha-sarcomeric actins in postnatal muscle.', Am J Physiol, vol. 273, pp. C1801 - C1810, http://dx.doi.org/10.1152/ajpcell.1997.273.6.C1801

Gunning P; Ferguson V; Brennan K; Hardeman E, 1997, 'Impact of α-skeletal actin but not α-cardiac actin on myoblast morphology', Cell Structure and Function, vol. 22, pp. 173 - 179, http://dx.doi.org/10.1247/csf.22.173

Coumans JVF; Yeoh T; Seeto RK; Keogh A; Brennan K; Gunning P; Hardeman E; Dos Remedies CG, 1997, 'Variations in the relative mRNA levels of actins and myosin heavy chains do not produce corresponding differences in their proteins in the adult human heart', Journal of Molecular and Cellular Cardiology, vol. 29, pp. 895 - 905, http://dx.doi.org/10.1006/jmcc.1996.0317

Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273, pp. C1801 - C1810

Dos Remedios CG; Berry DA; Carter LK; Coumans JVF; Heinke MY; Kiessling PC; Seeto RK; Thorvaldson T; Trahair T; Yeoh T, 1996, 'Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: Protein levels do not necessarily reflect mRNA levels', Electrophoresis, vol. 17, pp. 235 - 238, http://dx.doi.org/10.1002/elps.1150170140

Corin SJ; Levitt LK; O'Mahoney JV; Joya JE; Hardeman EC; Wade R, 1995, 'Delineation of a slow-twitch-myofiber-specific transcriptional element by using in vivo somatic gene transfer', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, pp. 6185 - 6189, http://dx.doi.org/10.1073/pnas.92.13.6185

Esser KA; Hardeman EC, 1995, 'Changes in contractile protein mRNA accumulation in response to spaceflight', American Journal of Physiology - Cell Physiology, vol. 268

Levitt LK; O'mahoney JV; Brennan KJ; Joya JE; Zhu L; Wade RP; Hardeman EC, 1995, 'The Human Troponin I Slow Promoter Directs Slow Fiber-Specific Expression in Transgenic Mice', DNA and Cell Biology, vol. 14, pp. 599 - 607, http://dx.doi.org/10.1089/dna.1995.14.599

Zhu L; Lyons GE; Juhasz O; Joya JE; Hardeman EC; Wade R, 1995, 'Developmental Regulation of Troponin I Isoform Genes in Striated Muscles of Transgenic Mice', Developmental Biology, vol. 169, pp. 487 - 503, http://dx.doi.org/10.1006/dbio.1995.1163

ESSER K; BRENNAN K; HARDEMAN E, 1995, 'WEIGHT-BEARING ACTIVITY, IN ADDITION TO INNERVATION, IS NECESSARY FOR THE ACQUISITION OF A SLOW CONTRACTILE PROTEIN MESSENGER-RNA PROFILE DURING REGENERATION', FASEB JOURNAL, vol. 9, pp. A655 - A655, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QM40600178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Esser KA; Hardeman EC, 1995, 'Changes in contractile protein mRNA accumulation in response to spaceflight.', Am J Physiol, vol. 268, pp. C466 - C471, http://dx.doi.org/10.1152/ajpcell.1995.268.2.C466

Dunwoodie SL; Joya JE; Arkell RM; Hardeman EC, 1994, 'Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle', Journal of Biological Chemistry, vol. 269, pp. 12212 - 12219

Brennan KJ; Hardeman EC, 1993, 'Quantitative analysis of the human α-skeletal actin gene in transgenic mice', Journal of Biological Chemistry, vol. 268, pp. 719 - 725

Sutherland CJ; Esser KA; Elsom VL; Gordon ML; Hardeman EC, 1993, 'Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation', Developmental Dynamics, vol. 196, pp. 25 - 36, http://dx.doi.org/10.1002/aja.1001960104

Esser K; Gunning P; Hardeman E, 1993, 'Nerve-dependent and -independent patterns of mRNA expression in regenerating skeletal muscle', Developmental Biology, vol. 159, pp. 173 - 183, http://dx.doi.org/10.1006/dbio.1993.1231

Hailstones D; Barton P; Chan-Thomas P; Sasse S; Sutherland C; Hardeman E; Gunning P, 1992, 'Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development', Journal of Biological Chemistry, vol. 267, pp. 23295 - 23300

Gunning P; Hardeman E, 1991, 'Multiple mechanisms regulate muscle fiber diversity', FASEB Journal, vol. 5, pp. 3064 - 3070

Sutherland CJ; Elsom VL; Gordon ML; Dunwoodie SL; Hardeman EC, 1991, 'Coordination of skeletal muscle gene expression occurs late in mammalian development', Developmental Biology, vol. 146, pp. 167 - 178, http://dx.doi.org/10.1016/0012-1606(91)90457-E

Webster KA; Gunning P; Hardeman E; Wallace DC; Kedes L, 1990, 'Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts', Journal of Cellular Physiology, vol. 142, pp. 566 - 573, http://dx.doi.org/10.1002/jcp.1041420316

Wade R; Sutherland C; Gahlmann R; Kedes L; Hardeman E; Gunning P, 1990, 'Regulation of contractile protein gene family mRNA pool sizes during myogenesis', Developmental Biology, vol. 142, pp. 270 - 282, http://dx.doi.org/10.1016/0012-1606(90)90348-M

Gunning P; Gordon M; Wade R; Gahlmann R; Lin CS; Hardeman E, 1990, 'Differential control of tropomyosin mRNA levels during myogenesis suggests the existence of an isoform competition-autoregulatory compensation control mechanism', Developmental Biology, vol. 138, pp. 443 - 453, http://dx.doi.org/10.1016/0012-1606(90)90210-A

Hardeman EC; Minty A; Benton-Vosman P; Kedes L; Blau HM, 1988, 'In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function', Journal of Cell Biology, vol. 106, pp. 1027 - 1034, http://dx.doi.org/10.1083/jcb.106.4.1027

WADE R; GUNNING P; HARDEMAN E; GAHLMANN R; BLAU H; KEDES L, 1987, 'DISTINCTIVE PATTERNS OF MUSCLE-SPECIFIC MESSENGER-RNA ACCUMULATION DURING HUMAN MYOGENESIS', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 96 - 96, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987G822600243&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Gunning P; Hardeman E; Wade R; Ponte P; Bains W; Blau HM; Kedes L, 1987, 'Differential patterns of transcript accumulation during human myogenesis.', Molecular and cellular biology, vol. 7, pp. 4100 - 4114, http://dx.doi.org/10.1128/MCB.7.11.4100

Hardeman EC; Chiu CP; Minty A; Blau HM, 1986, 'The pattern of actin expression in human fibroblast × mouse muscle heterokaryons suggests that human muscle regulatory factors are produced', Cell, vol. 47, pp. 123 - 130, http://dx.doi.org/10.1016/0092-8674(86)90373-9

KEDES L; MINTY A; WADE R; GUNNING P; HARDEMAN E; BLAU H; BENTONVOSMAN P; BOXER L; ERBA H; FELDMAN D, 1986, 'MULTILEVEL REGULATION OF GENE-EXPRESSION IN HUMAN MYOGENESIS - DISSOCIATION OF FACTORS RESPONSIBLE FOR MODULATION AND ACTIVATION AND EVIDENCE FOR NON-COORDINATE EXPRESSION', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 16 - 16, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986A664400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Blau HM; Pavlath GK; Hardeman EC; Chiu CP; Silberstein L; Webster SG; Miller SC; Webster C, 1985, 'Plasticity of the differentiated state', Science, vol. 230, pp. 758 - 766, http://dx.doi.org/10.1126/science.2414846

Skalnik DG; Brown DA; Brown PC; Friedman RL; Hardeman EC; Schimke RT; Simoni RD, 1985, 'Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines', Journal of Biological Chemistry, vol. 260, pp. 1991 - 1994

Garrison JC; Hardeman E; Wade R; Kedes L; Gunning P, 1985, 'Isolation of full-length cDNAs encoding abundant adult human skeletal muscle mRNAs', Gene, vol. 38, pp. 177 - 188, http://dx.doi.org/10.1016/0378-1119(85)90216-1

Hardeman EC; Endo A; Simoni RD, 1984, 'Effects of compactin on the levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase in compactin-resistant C100 and wild-type cells', Archives of Biochemistry and Biophysics, vol. 232, pp. 549 - 561, http://dx.doi.org/10.1016/0003-9861(84)90572-1

CHIU CP; HARDEMAN EC; GUNNING P; BLAU HM, 1984, 'TRANSCRIPTIONAL ACTIVATION OF SARCOMERIC ACTINS IN MUSCLE X NONMUSCLE HETEROKARYONS', JOURNAL OF CELL BIOLOGY, vol. 99, pp. A346 - A346, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TM94901278&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hardeman EC; Jenke HS; Simoni RD, 1983, 'Overproduction of a M(r) 92,000 protomer of 3 hydroxy 3 methylglutaryl coenzyme A reductase in compactin-resistant C100 cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 1516 - 1520, http://dx.doi.org/10.1073/pnas.80.6.1516

Rine J; Hansen W; Hardeman E; Davis RW, 1983, 'Targeted selection of recombinant clones through gene dosage effects', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 6750 - 6754, http://dx.doi.org/10.1073/pnas.80.22.6750

Brusilow WSA; Gunsalus RP; Hardeman EC, 1981, 'In vitro synthesis of the F0and F1components of the proton translocating ATPase of Escherichia coli', Journal of Biological Chemistry, vol. 256, pp. 3141 - 3144

Ryan J; Hardeman EC; Endo A; Simoni RD, 1981, 'Isolation and characterization of cells resistant to ML236B (Compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase', Journal of Biological Chemistry, vol. 256, pp. 6762 - 6768

Conference Papers

Tinklenberg J; Meng H; Yang L; Hardeman E; Pearsall S; Fitts R; Lawlor M, 2014, 'Treatment with ActRIIB-mFc Improves Lifespan, Behavior and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy', in JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, Portland, OR, pp. 614 - 614, presented at 90th Annual Meeting of the American-Association-of-Neuropathologists-Inc, Portland, OR, 12 - 15 June 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336732100120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Kee AJ; Lucas CA; Yang L; Szokolai RC; Martel N; Leong GM; Muscat GE; Hughes W; Cooney G; James DE, 2012, 'The actin regulatory protein Tropomyosin 5NM1 regulates glucose uptake and GLUT4 trafficking in the mouse.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601218&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Laing NG; Nowak KJ, 2012, 'Efficacy of cardiac actin over-expression therapy for ACTA1 disease seems mutation specific', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Perth, AUSTRALIA, pp. 839 - 839, presented at 17th International Congress of the World-Muscle-Society (WMS), Perth, AUSTRALIA, 09 - 13 October 2012, http://dx.doi.org/10.1016/j.nmd.2012.06.125

Hardeman EC; Darhed HA; Lee ASJ; Chen G; Shah J; Joya JE; Gunning PW, 2012, 'BLOOD BORNE AGENTS RESCUE REGENERATION IMPAIRED MUSCLE', in WOUND REPAIR AND REGENERATION, WILEY-BLACKWELL, pp. A59 - A59, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308945000025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Butler T; Allanson M, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in EXPERIMENTAL DERMATOLOGY, WILEY-BLACKWELL, Marburg, GERMANY, pp. e43 - e43, presented at 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg, GERMANY, 01 - 03 March 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300931700252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Curthoys N; Freittag H; Connor A; Desouza M; Hardeman E; Gunning P; Schevzov G; Fath T, 2011, 'Tropomyosins induce neurite formation in B35 neuroblastoma cells and control neurite branching', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505503094&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Kee A; Lucas C; Szokolai R; Yang L; Martel N; Leong G; Muscat G; Hughes W; James D; Gunning P, 2011, 'A novel actin filament class that regulates glucose uptake and GLUT4 trafficking', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505500204&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Stehn J; Schevzov G; Bonello T; McCluskey A; Haass N; Palmer S; Hardeman E; Allanson M; Reeve V; Gunning P, 2010, 'Tropomyosin Tm5NM1: A novel target for cancer therapy', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Berlin, GERMANY, pp. 107 - 107, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Berlin, GERMANY, 16 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)72041-3

Yang N; MacArthur DG; Kee AJ; Kettle E; Hardeman EC; Lemckert F; Hook J; Gunning PW; North KN, 2006, 'An alpha -actinin-3 Knockout Mouse Suffers Increased Sarcomeric Damage from Eccentric Exercise', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, pp. S123 - S124, http://dx.doi.org/10.1249/00005768-200605001-01445

Domazetovska A; Ilkovski B; Cooper S; Valova V; Lemckert F; Hook J; Hardeman E; Robinson P; Yang N; Gunning P, 2006, 'Unravelling the thin filament: mechanisms of weakness in inherited muscle disease', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Istanbul, TURKEY, pp. S60 - S61, presented at 11th International Congress on Neuromuscular Diseases, Istanbul, TURKEY, 02 - 07 July 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Macarthur D; Yang N; Seto J; Raftery J; Kee A; Hardeman E; Gunning P; North K, 2006, 'A gene for speed: the ACTN3 R577X polymorphism influences muscle performance', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Istanbul, TURKEY, pp. S59 - S59, presented at 11th International Congress on Neuromuscular Diseases, Istanbul, TURKEY, 02 - 07 July 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Schevzov G; Vrhovski B; Bryce NS; Elmir S; Qiu M; Yang N; Verrills NM; Kavallaris M; Puttur F; Hardeman E, 2004, 'Tropomyosin antibodies identify functionally distinct populations of actin filaments', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Washington, DC, pp. 143A - 143A, presented at Annual Meeting of the American-Society-for-Cell-Biology, Washington, DC, 04 - 08 December 2004, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224648801136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Hardeman EC; Nguyen MA; Corbett MA; Ghoddusi M; Joya JE; Gunning PW; North KN, 2003, 'A mouse model for severe actin nemaline myopathy', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, SZEGED, HUNGARY, pp. 620 - 620, presented at 8th International Congress of the World-Muscle-Society, SZEGED, HUNGARY, 03 - 06 September 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000185007600028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Posters

Hardeman EC; Kee AJ; Lucas CA; Chagan J; Gunning PW, 2016, 'Metabolic impact of targeting the tropomyosin/actin cytoskeleton to treat cancer', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, San Francisco, CA, Vol. 27, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), San Francisco, CA, 03 - 07 December 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396046900905&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348705376&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Presentations

Conference Abstracts

Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Hardeman E; Cohn RJ; Barres R, 2015, 'Radiation-induced metabolic complications: potential role for the microbiota', in Radiation-induced metabolic complications: potential role for the microbiota, Nutrient & Metabolite Sensing, Copenhagen, Denmark, presented at Nutrient & Metabolite Sensing, Copenhagen, Denmark, 01 - 05 November 2015

Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Cohn R; Hardeman E; Barres R, (eds.), 2015, 'Metabolic complications in cancer survivors: role of adipose tissue dysfunction', in Metabolic complications in cancer survivors: role of adipose tissue dysfunction, Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, presented at Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, 09 - 13 February 2015

Segueira VB; Stehn JR; Haass N; Bonello T; Guven K; Desouza M; Schevzov G; Kottyan G; McCluskey A; Bischof L, 2012, 'Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-5230

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