Emeritus Professor Peter Barry | Brain Sciences UNSW

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University role:

Emeritus Professor

Phone:

+61 2 9385 1101

Email:

p.barry@unsw.edu.au

Peter Barry is an Emeritus Professor in the School of Medical Sciences and Department of Physiology from 2003. He had also been a Conjoint Professor from 2002-2015. Prior to that he had been a Professor of Physiology from 1994-2001, before he retired in 2002. His research is in membrane biophysics. He originally graduated from the University of Sydney (Australia) with a BSc (Hons) in Physics in 1963, followed by a PhD in Biophysics in 1968. He then did 3 years (1967-1970) of post-doctoral work with Dr Jared Diamond in Physiology at the University of California at Los Angeles (UCLA), just over a year at the Physiological Laboratory in the University of Cambridge (1970-1971), working with Dr Richard Adrian before coming to UNSW, initially for 2 years as a Q E II Fellow (1972 &1973) collaborating with Dr Peter Gage, and taking up a lectureship in the School of Physiology and Pharmacology in 1974.

Research Interests:
His interests and those of his research groups have included exploring the mechanisms of ion permeation and selectivity in ion channels, the relationship between the molecular structure and the physiological function of channels, such as those of the inhibitory neurotransmitter receptor glycine channel and the olfactory cyclic nucleotide-gated channel, and investigating the factors that determine their ion permeation, selectivity and conductance. For many years, it also included the role of unstirred-layers on biological phenomena. Many of these studies highlighted the significant effects of liquid junction potentials on membrane potential measurement, which are generally increased in patch-clamp situations. This resulted in analyses to evaluate and correct errors arising from such liquid junction potentials in a range of different situations and led him to develop a C/C++ DOS-based Windows software program, JPCalc, to calculate and apply appropriate corrections to experimental membrane potential measurements. The program was subsequently reprogrammed into full Windows versions; see Interactive Electrophysiology Software. His current research is now concentrating on liquid junction potential effects on membrane potential measurements and their role in ion permeation and selectivity, and the reliability of their calculation and measurement, including the importance of using ion activities in their calculation in many situations, and complications that can arise in solutions containing polyvalent ion mixtures.

Broad Research Areas:
Membrane Biophysics, Electrophysiology, Physiology, Neuroscience

Qualifications:

BSc (Hons), PhD (Syd), DSc (NSW)

Society Memberships & Professional Activities:
President, Australian Society for Biophysics, 2003-2004; Member, National Committee for Biomedical Sciences of the Australian Academy of Science, 2003-2005;, Emeritus member of The Biophysical Society (U.S.A.); Honorary Life member of The Australian Physiological and Pharmacological Society. Currently also Emeritus member of the New York Academy of Sciences (U.S.A.); Emeritus member of The Society of General Physiologists (U.S.A); The Australian Society for Biophysics; Association: Fellow of the Institute for the Study of Christianity in an Age of Science and Technology (ISCAST).

Specific Research Keywords:
Liquid Junction Potentials, Ion Channels, Structure & Function of Ion Channels, Ligand gated ion channels, Unstirred Layer Effects

Research

Publications related to this Person

Book Chapters

Moorhouse AJ; Lewis TM; Barry PH, 2015, 'Analyzing Ion Permeation in Channels and Pumps Using Patch-Clamp Recording', in Pumps, Channels and Transporters: Methods of Functional Analysis, pp. 51 - 88, http://dx.doi.org/10.1002/9781119085126.ch3

Barry PH; Qu W; Moorhouse AJ, 2008, 'Biophysics of CNG Ion Channels', in Martinac B (ed.), Sensing with Ion Channels, edn. Original, Springer, Berlin Heidelberg, pp. 175 - 200

Lynch JW; Barry PH, 2007, 'Ligand-Gated Ion Channels: Permeation and Activation', in Chung SH; Krishnamurthy V; Anderson OS (ed.), Biological Membrane Ion Channels, edn. 1, Springer-Verlag, New York, pp. 334 - 367

Barry PH; Balasubramanian S; Lynch JW, 1999, 'How sensory cells encode information: the processes that underly sensitivity to chemical stimuli, their quality and their quantity', in Tastes & Aromas. The Chemical Senses in Science and Industry, edn. Original, University of New South Wales Press, Sydney, Australia, pp. 120 - 129

Journal articles

Barry PH, 2009, 'Reminiscences of work with Alex Hope: the movement of water and ions in giant algal cells, 1963-1967.', Reminiscences of work with Alex Hope: the movement of water and ions in giant algal cells, 1963-1967., vol. 39, pp. 179 - 184, http://dx.doi.org/10.1007/s00249-009-0436-y

Carland JE; Cooper MA; Sugiharto S; Jeong HJ; Lewis TM; Barry PH; Peters JA; Lambert JJ; Moorhouse AJ, 2009, 'Characterization of the effects of charged residues in the intracellular loop on ion permeation in α1 glycine receptor channels', Journal of Biological Chemistry, vol. 284, pp. 2023 - 2030, http://dx.doi.org/10.1074/jbc.M806618200

Sugiharto S; Lewis TM; Moorhouse AJ; Schofield PR; Barry PH, 2008, 'Anion-cation permeability correlates with hydrated counterion size in glycine receptor channels', Biophysical Journal, vol. 95, pp. 4698 - 4715, http://dx.doi.org/10.1529/biophysj.107.125690

Barry PH, 2006, 'The reliability of relative anion-cation permeabilities deduced from reversal (dilution) potential measurements in ion channel studies', Cell Biochemistry and Biophysics, vol. 46, pp. 143 - 154, http://dx.doi.org/10.1385/CBB:46:2:143

Qu W; Moorhouse AJ; Chandra M; Pierce KD; Lewis TM; Barry PH, 2006, 'A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel', Journal of General Physiology, vol. 127, pp. 375 - 389

Barry PH; O'Mara ML, 2005, 'The reliability of relative cation-anion permeabilities deduced from reversal (dilution) potential measurements in ion channel studies, and Brownian dynamics predictions', FASEB JOURNAL, vol. 19, pp. A1170 - A1170, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000227610901246&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Barry PH; Lynch JW, 2005, 'Ligand-gated channels', IEEE Transactions on Nanobioscience, vol. 4, pp. 70 - 80, http://dx.doi.org/10.1109/TNB.2004.842497

Qu W; Moorhouse AJ; Lewis TM; Pierce KD; Barry PH, 2005, 'Mutation of the pore glutamate affects both cytoplasmic and external dequalinium block in the rat olfactory CNGA2 channel', European Biophysics Journal, vol. 34, pp. 442 - 453, http://dx.doi.org/10.1007/s00249-005-0479-7

Carland JE; Moorhouse AJ; Barry PH; Johnston GAR; Chebib M, 2004, 'Charged residues at the 2′ position of human GABAC ρ1 receptors invert ion selectivity and influence open state probability', Journal of Biological Chemistry, vol. 279, pp. 54153 - 54160, http://dx.doi.org/10.1074/jbc.M410625200

Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2004, 'Ligand-gated ion channels: Mechanisms underlying ion selectivity', Progress in Biophysics and Molecular Biology, vol. 86, pp. 161 - 204, http://dx.doi.org/10.1016/j.pbiomolbio.2003.09.002

O'Mara M; Barry PH; Chung SH, 2003, 'A model of the glycine receptor deduced from Brownian dynamics studies', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, pp. 4310 - 4315, http://dx.doi.org/10.1073/pnas.0630652100

Lee DJS; Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 2003, 'The contribution of proline 250 (P-2′) to pore diameter and ion selectivity in the human glycine receptor channel', Neuroscience Letters, vol. 351, pp. 196 - 200, http://dx.doi.org/10.1016/j.neulet.2003.08.005

Moorhouse AJ; Keramidas A; Zaikine A; Zaykin A; Schofield PR; Barry PH, 2002, 'Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels', Journal of General Physiology, vol. 119, pp. 411 - 425

Keramidas A; Moorhouse AJ; Pierce K; Schofield PR; Barry PH, 2002, 'Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion charge selectivity', Journal of General Physiology, vol. 119, pp. 393 - 410

Kaur R; Zhu XO; Moorhouse AJ; Barry PH, 2001, 'IP3-gated channels and their occurrence relative to CNG channels in the soma and dendritic knob of rat olfactory receptor neurons.', J Membr Biol, vol. 181, pp. 91 - 105, https://www.ncbi.nlm.nih.gov/pubmed/11420596

Friedrich O; Ehmer T; Uttenweiler D; Vogel M; Barry PH; Fink RHA, 2001, 'Numerical analysis of Ca²⁺ depletion in the transverse tubular system of mammalian muscle', Biophysical Journal, vol. 80, pp. 2046 - 2055, http://dx.doi.org/10.1016/S0006-3495(01)76178-4

Qu W; Moorhouse AJ; Cunningham AM; Barry PH, 2001, 'Anomalous mole-fraction effects in recombinant and native cyclic nucleotide-gated channels in rat olfactory receptor neurons', Proceedings of the Royal Society B: Biological Sciences, vol. 268, pp. 1395 - 1403, http://dx.doi.org/10.1098/rspb.2001.1663

Qu W; Moorhouse AJ; Rajendra S; Barry PH, 2000, 'Very negative potential for half-inactivation of, and effects of anions on, voltage-dependent sodium currents in acutely isolated rat olfactory receptor neurons', Journal of Membrane Biology, vol. 175, pp. 123 - 138, http://dx.doi.org/10.1007/s002320001061

Keramidas A; Moorhouse AJ; French CR; Schofield PR; Barry PH, 2000, 'M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective', Biophysical Journal, vol. 79, pp. 247 - 259, http://dx.doi.org/10.1016/S0006-3495(00)76287-4

Qu W; Zhu XO; Moorhouse AJ; Bieri S; Cunningham AM; Barry PH, 2000, 'Ion permeation and selectivity of wild-type recombinant rat CNG (rOCNC1) channels expressed in HEK293 cells', Journal of Membrane Biology, vol. 178, pp. 137 - 150, http://dx.doi.org/10.1007/s002320010021

Keramidas A; Kuhlmann L; Moorhouse AJ; Barry PH, 1999, 'Measurement of the limiting equivalent conductivities and mobilities of the most prevalent ionic species of EGTA (EGTA^2- and EGTA^3-) for use in electrophysiological experiments', Journal of Neuroscience Methods, vol. 89, pp. 41 - 47, http://dx.doi.org/10.1016/S0165-0270(99)00036-9

Moorhouse AJ; Jacques P; Barry PH; Schofield PR, 1999, 'The startle disease mutation Q266H, in the second transmembrane domain of the human glycine receptor, impairs channel gating', Molecular Pharmacology, vol. 55, pp. 386 - 395, http://dx.doi.org/10.1124/mol.55.2.386

Barry PH; Schofield PR; Moorhouse AJ, 1999, 'Glycine receptors: What gets in and why?', Clinical and Experimental Pharmacology and Physiology, vol. 26, pp. 935 - 936, http://dx.doi.org/10.1046/j.1440-1681.1999.03149.x

Bell GA; Barry PH; Kaur R, 1999, 'Odorant-induced patch-clamp responses in rat olfactory receptor neurons', ChemoSense, vol. 2, pp. 7

Barry PH; Schofield PR; Moorhouse AJ, 1999, 'Glycine receptors: What gets in and why?', Clinical and Experimental Pharmacology and Physiology, pp. 935 - 936

Fatima-Shad K; Barry PH, 1998, 'Morphological and electrical characteristics of postnatal hippocampal neurons in culture: The presence of bicuculline- and strychnine-sensitive IPSPs', Tissue and Cell, vol. 30, pp. 236 - 250, http://dx.doi.org/10.1016/S0040-8166(98)80072-4

Barry PH, 1998, 'Derivation of unstirred-layer transport number equations from the Nernst-Planck flux equations', Biophysical Journal, vol. 74, pp. 2903 - 2905, http://dx.doi.org/10.1016/S0006-3495(98)77996-2

Barry PH; Chiu P; Lynch JW, 1998, 'An analysis of odorant-induced currents in on-cell patches on mammalian olfactory receptor neurons', Annals of the New York Academy of Sciences, vol. 855, pp. 208 - 211, http://dx.doi.org/10.1111/j.1749-6632.1998.tb10568.x

Hallani M; Lynch JW; Barry PH, 1998, 'Characterisation of calcium-activated chloride channels in patches excised from the dendritic', Journal of Membrane Biology, vol. 161, pp. 163 - 171

Chiu P; Lynch JW; Barry PH, 1997, 'Odorant-induced currents in intact patches from rat olfactory receptor neurons: Theory and experiment', Biophysical Journal, vol. 72, pp. 1442 - 1457, http://dx.doi.org/10.1016/S0006-3495(97)78791-5

Balasubramanian S; Lynch JW; Barry PH, 1997, 'Concentration dependence of sodium permeation and sodium ion interactions in the cyclic AMP-gated channels of mammalian olfactory receptor neurons', Journal of Membrane Biology, vol. 159, pp. 41 - 52, http://dx.doi.org/10.1007/s002329900267

Lynch JW; Rajendra S; Pierce K; Handford CA; Barry PH; Schofield PR, 1997, 'Identification of intracellular and extracellular domains mediating signal transduction in the inhiBitory glycine receptor chloride channel', European Molecular Biology Organization, vol. 16, pp. 110 - 120

Balasubramanian S; Lynch JW; Barry PH, 1996, 'Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor', Journal of Membrane Biology, vol. 152, pp. 13 - 23, http://dx.doi.org/10.1007/s002329900081

Schofield PR; Lynch JW; Rajendra S; Pierce KD; Handford CA; Barry PH, 1996, 'Molecular and genetic insights into ligand binding and signal transduction at the inhibitory glycine receptor', Cold Spring Harbor Symposia on Quantitative Biology, vol. 61, pp. 333 - 342

Ng B; Barry PH, 1995, 'The measurement of ionic conductivities and mobilities of certain less common organic ions needed for junction potential corrections in electrophysiology', Journal of Neuroscience Methods, vol. 56, pp. 37 - 41, http://dx.doi.org/10.1016/0165-0270(94)00087-W

Balasubramanian S; Lynch JW; Barry PH, 1995, 'The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons', The Journal of Membrane Biology, vol. 146, pp. 177 - 191, http://dx.doi.org/10.1007/BF00238007

Fatima-Shad K; Barry PH, 1995, 'Heterogeneous current responses to GABA and glycine are present in post-natally cultured hippocampal neurons', Brain Research, vol. 704, pp. 246 - 255, http://dx.doi.org/10.1016/0006-8993(95)01130-7

Lynch JW; Rajendra S; Barry PH; Schofield PR, 1995, 'Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator', Journal of Biological Chemistry, vol. 270, pp. 13799 - 13806, http://dx.doi.org/10.1074/jbc.270.23.13799

Rajendra S; Lynch JW; Pierce KD; French CR; Barry PH; Schofield PR, 1995, 'Mutation of an arginine residue in the human glycine receptor transforms β-alanine and taurine from agonists into competitive antagonists', Neuron, vol. 14, pp. 169 - 175, http://dx.doi.org/10.1016/0896-6273(95)90251-1

Rajendra S; Vandenberg RJ; Pierce KD; Cunningham AM; French PW; Barry PH; Schofield PR, 1995, 'The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element', EMBO Journal, vol. 14, pp. 2987 - 2998

Barry PH; Kaneez F, 1995, 'Amino acid residues and control of ion permeation through a ligand-gated ion channel superfamily', Today's Life Science, pp. 32 - 37

Barry PH, 1994, 'ARTMEM-An interactive graphical program simulating membrane potential measurements across artificial membranes', Annals of Biomedical Engineering, vol. 22, pp. 218 - 225, http://dx.doi.org/10.1007/BF02390380

Barry PH, 1994, 'JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements', Journal of Neuroscience Methods, vol. 51, pp. 107 - 116, http://dx.doi.org/10.1016/0165-0270(94)90031-0

Rajendra S; Lynch JW; Pierce KD; French CR; Barry PH; Schofield PR, 1994, 'Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor', Journal of Biological Chemistry, vol. 269, pp. 18739 - 18742

Fatima-Shad K; Barry PH, 1993, 'Anion permeation in GABA- and glycine-gated channels of mammalian cultured hippocampal neurons', Proceedings of the Royal Society B: Biological Sciences, vol. 253, pp. 69 - 75, http://dx.doi.org/10.1098/rspb.1993.0083

Vandenberg RJ; Rajendra S; French CR; Barry PH; Schofield PR, 1993, 'The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site', Molecular Pharmacology, vol. 44, pp. 198 - 203

Vandenberg RJ; French CR; Barry PH; Shine J; Schofield PR, 1992, 'Antagonism of ligand-gated ion channel receptors: Two domains of the glycine receptor α subunit form the strychnine-binding site', Proceedings of the National Academy of Sciences of the United States of America, vol. 89, pp. 1765 - 1769, http://dx.doi.org/10.1073/pnas.89.5.1765

Fatima-Shad K; Barry PH, 1992, 'A patch-clamp study of GABA- and strychnine-sensitive glycine-activated currents in post-natal tissue-cultured hippocampal neurons', Proceedings of the Royal Society B: Biological Sciences, vol. 250, pp. 99 - 105, http://dx.doi.org/10.1098/rspb.1992.0136

Rajendra S; Lynch JW; Barry PH, 1992, 'An analysis of Na⁺ currents in rat olfactory receptor neurons', Pflügers Archiv European Journal of Physiology, vol. 420, pp. 342 - 346, http://dx.doi.org/10.1007/BF00374468

Lynch JW; Barry PH, 1991, 'Properties of transient K+ currents and underlying single K+ channels in rat olfactory receptor neurons', The Journal of General Physiology, vol. 97, pp. 1043 - 1072, http://dx.doi.org/10.1085/jgp.97.5.1043

Lynch JW; Barry PH, 1991, 'Inward rectification in rat olfactory receptor neurons', Proceedings of the Royal Society B: Biological Sciences, vol. 243, pp. 149 - 153, http://dx.doi.org/10.1098/rspb.1991.0024

Barry PH; Lynch JW, 1991, 'Liquid junction potentials and small cell effects in patch-clamp analysis', The Journal of Membrane Biology, vol. 121, pp. 101 - 117, http://dx.doi.org/10.1007/BF01870526

Lynch JW; Barry PH, 1991, 'Slowly activating K⁺ channels in rat olfactory receptor neurons', Proceedings of the Royal Society B: Biological Sciences, vol. 244, pp. 219 - 225, http://dx.doi.org/10.1098/rspb.1991.0074

Barry PH; Quartararo N, 1990, 'PNSCROLL, a software package for graphical interactive analysis of single channel patch clamp currents and other binary file records: Under mouse control', Computers in Biology and Medicine, vol. 20, pp. 193 - 204, http://dx.doi.org/10.1016/0010-4825(90)90005-A

Barry PH, 1990, 'Membrane potential simulation program for IBM-PC-compatible equipment for physiology and biology students.', The American journal of physiology, vol. 259

Lynch JW; Barry PH, 1989, 'Action potentials initiated by single channels opening in a small neuron (rat olfactory receptor)', Biophysical Journal, vol. 55, pp. 755 - 768, http://dx.doi.org/10.1016/S0006-3495(89)82874-7

Barry PH, 1989, 'Ionic permeation mechanisms in epithelia: Biionic potentials, dilution potentials, conductances, and streaming potentials', Methods in Enzymology, vol. 171, pp. 678 - 715, http://dx.doi.org/10.1016/S0076-6879(89)71038-7

Quartararo N; Barry PH, 1988, 'Ion permeation through single ACh-activated channels in denervated adult toad sartorius skeletal muscle fibres: effect of temperature', Pflügers Archiv European Journal of Physiology, vol. 411, pp. 101 - 112, http://dx.doi.org/10.1007/BF00581653

Lynch JW; Barry PH; Quartararo N, 1988, 'A temperature and solution control system for the measurement of single channel currents in excised membrane patches', Pflügers Archiv European Journal of Physiology, vol. 412, pp. 322 - 327, http://dx.doi.org/10.1007/BF00582515

Quartararo N; Barry PH; Gage PW, 1987, 'Ion permeation through single channels activated by acetylcholine in denervated toad sartorius skeletal muscle fibers: Effects of alkali cations', The Journal of Membrane Biology, vol. 97, pp. 137 - 159, http://dx.doi.org/10.1007/BF01869420

Quartararo N; Barry PH, 1987, 'A simple technique for transferring excised patches of membrane to different solutions for single channel measurements', Pflügers Archiv European Journal of Physiology, vol. 410, pp. 677 - 678, http://dx.doi.org/10.1007/BF00581332

Barry PH; Diamond JM, 1984, 'Effects of unstirred layers on membrane phenomena.', Physiol Rev, vol. 64, pp. 763 - 872, http://dx.doi.org/10.1152/physrev.1984.64.3.763

Barry PH; Dulhunty AF, 1984, 'Slow potential changes in mammalian muscle fibers during prolonged hyperpolarization: Transport number effects and chloride depletion', The Journal of Membrane Biology, vol. 78, pp. 235 - 248, http://dx.doi.org/10.1007/BF01925971

Barry PH; Gage PW, 1984, 'Ionic Selectivity of Channels at the End Plate', Current Topics in Membranes and Transport, vol. 21, pp. 1 - 51, http://dx.doi.org/10.1016/S0070-2161(08)60434-7

Barry PH, 1984, 'Slow potential changes due to transport number effects in cells with unstirred membrane invaginations or dendrites', The Journal of Membrane Biology, vol. 82, pp. 221 - 239, http://dx.doi.org/10.1007/BF01871632

Takeda K; Barry PH; Gage PW, 1982, 'Effects of extracellular sodium concentration on null potential, conductance and open time of endplate channels.', Proc R Soc Lond B Biol Sci, vol. 216, pp. 225 - 251, http://dx.doi.org/10.1098/rspb.1982.0072

Takeda K; Gage PW; Barry PH, 1982, 'Effects of divalent cations on toad end-plate channels', The Journal of Membrane Biology, vol. 64, pp. 55 - 66, http://dx.doi.org/10.1007/BF01870768

Takeda K; Barry PH; Gage PW, 1980, 'Effects of ammonium ions on endplate channels', Journal of General Physiology, vol. 75, pp. 589 - 613, http://dx.doi.org/10.1085/jgp.75.5.589

Barry PH; Gage PW; Van Helden DF, 1979, 'Cation permeation at the amphibian motor end-plate', The Journal of Membrane Biology, vol. 45, pp. 245 - 276, http://dx.doi.org/10.1007/BF01869288

Barry PH; Gage PW; Van Helden DF, 1979, 'End-plate channels behave as neutral site channels', Neuroscience Letters, vol. 11, pp. 233 - 237, http://dx.doi.org/10.1016/0304-3940(79)90134-4

Barry PH, 1977, 'Transport number effects in the transverse tubular system and their implications for low frequency impedance measurement of capacitance of skeletal muscle fibers', The Journal of Membrane Biology, vol. 34, pp. 383 - 408, http://dx.doi.org/10.1007/BF01870310

Barry PH; Adrian RH; Barry PH, 1973, 'Slow conductance changes due to potassium depletion in the transverse tubules of frog muscle fibers during hyperpolarizing pulses', The Journal of Membrane Biology, vol. 14, pp. 243 - 292, http://dx.doi.org/10.1007/bf01868081

Barry PH; Diamond JM; Wright EM, 1971, 'The mechanism of cation permeation in rabbit gallbladder', The Journal of Membrane Biology, vol. 4, pp. 358 - 394, http://dx.doi.org/10.1007/bf02431979

Wright EM; Barry PH; Diamond JM, 1971, 'The mechanism of cation permeation in rabbit gallbladder', The Journal of Membrane Biology, vol. 4, pp. 331 - 357, http://dx.doi.org/10.1007/bf02431978

Barry PH; Diamond JM, 1971, 'A theory of ion permeation through membranes with fixed neutral sites', The Journal of Membrane Biology, vol. 4, pp. 295 - 330, http://dx.doi.org/10.1007/bf02431977

Barry PH, 1970, 'Volume flows and pressure changes during an action potential in cells ofChara australis', The Journal of Membrane Biology, vol. 3, pp. 335 - 371, http://dx.doi.org/10.1007/bf01868023

Barry PH, 1970, 'Volume flows and pressure changes during an action potential in cells ofChara australis', The Journal of Membrane Biology, vol. 3, pp. 313 - 334, http://dx.doi.org/10.1007/bf01868022

Barry PH; Diamond JM, 1970, 'Junction potentials, electrode standard potentials, and other problems in interpreting electrical properties of membranes', The Journal of Membrane Biology, vol. 3, pp. 93 - 122, http://dx.doi.org/10.1007/bf01868010

Barry PH; Hope AB, 1969, 'Electro-osmosis in chara and nitella cells', Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 193, pp. 124 - 128, http://dx.doi.org/10.1016/0005-2736(69)90065-0

Barry PH; Hope AB, 1969, 'Electroosmosis in Membranes: Effects of Unstirred Layers and Transport Numbers', Biophysical Journal, vol. 9, pp. 729 - 757, http://dx.doi.org/10.1016/s0006-3495(69)86414-3

Barry PH; Hope AB, 1969, 'Electroosmosis in Membranes: Effects of Unstirred Layers and Transport Numbers', Biophysical Journal, vol. 9, pp. 700 - 728, http://dx.doi.org/10.1016/s0006-3495(69)86413-1

Conference Papers

Qu W; Zhu X; Moorhouse AJ; Bieri S; Cunningham AL; Barry PH; Kaur R, 2000, 'Properties of mammalian olfactory CNG and ip3-gated ion channels involved in olfactory transduction', in ChemoSense, 3rd Annual Meeting of AACS, Swinburne Univ, Melbourne, pp. 6, presented at 3rd Annual Meeting of AACS, Swinburne Univ, Melbourne, 01 December 2000

Keramidas A; Moorhouse AJ; Pierce K; Schofield PR; Barry PH, 2000, 'The effects of various mutations which convert recombinant glycine receptor channels to being cation selective', in Proceedings of the Australian Physiological and Pharmacological Society, 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, pp. 30, presented at 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, 27 - 29 September 1999

Keramidas A; Moorhouse AJ; Barry PH; Schofield PR, 2000, 'Pore mutations that convert a glycine receptor channel from being anion to cation selective', in Proceedings of Aust Neuroscience Society, 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, pp. 86, presented at 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, 30 January - 02 February 2000

Kaur R; Moorhouse AJ; Barry PH, 2000, 'Single-channel study of inositol-1,4,5-trisphosphate-gated channels in rat olfactory receptor neurons', in Proceedings of Aust Neuroscience Society, 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, pp. 37, presented at 20th annual meeting Australian Neuroscience Society, Melbourne Convention Centre, 30 January - 02 February 2000

Fatima-Shad K; Barry PH; Whitelaw ML, 1999, 'The 5HT3R Channel: An approach to compare it with other members of ligand-gated ion channel super family', in Meeting of Genomic Conference, Meeting of Genomic Conference, Melbourne, pp. 67 - 68, presented at Meeting of Genomic Conference, Melbourne, 01 March 1999

Kaur R; Qu W; Barry PH, 1999, 'Electrical properties of dissociated rat olfactory receptor neurons', in 1st Annual Scientific Meeting AACS, 1st Annual Scientific Meeting AACS, Garvan Institute, Sydney, pp. 1, presented at 1st Annual Scientific Meeting AACS, Garvan Institute, Sydney, 06 October 1999

Kaur R; Bell GA; Barry PH, 1999, 'Odorant-induced patch-clamp responses in rat olfactory receptor neurons', in 1st Annual Scientific Meeting AACS, 1st Annual Scientific Meeting AACS, Garvan Institute, Sydney, pp. 1, presented at 1st Annual Scientific Meeting AACS, Garvan Institute, Sydney, 06 October 1999

Keramidas A; Moorhouse AJ; French C; Schofield PR; Barry PH, 1999, 'Mutations in ligand-gated ion channels, such as the glycine receptor channel, that switch anion-to-cation selectivity', in 23rd Annual Meeting of the Australian Society for Biophysics, 23rd Annual Meeting of the Australian Society for Biophysics, Gold Coast, Qld, pp. 33, presented at 23rd Annual Meeting of the Australian Society for Biophysics, Gold Coast, Qld, 30 September 1999

Keramidas A; Moorhouse AJ; Schofield PR; Barry PH, 1999, 'The `Reverse Galzi` triple mutation converts the glycine receptor channel selectivity from anionic to cationic', in Proceedings of the Australian Physiological and Pharmacological Society, 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, pp. 55P, presented at 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, 27 - 29 September 1999

Qu W; Moorhouse AJ; Rajendra S; Barry PH, 1999, 'The effects of anions on voltage-dependent sodium currents in dissociated rat olfactory receptor neurons', in Proceedings of the Australian Physiological and Pharmacological Society, 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, pp. 61P, presented at 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, 27 - 29 September 1999

Barry PH; Moorhouse AJ; Kaur R, 1999, 'Inositol-1,4,5-triphosphate-gated channels in excised membrane patches from the soma and dendtritic knob of rat olfactory receptor neurons', in Proceedings of the Australian Physiological and Pharmacological Society, 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, pp. 9P, presented at 67th Meeting of Physiology and Pharmacology Society, University of Newcastle, NSW, 27 - 29 September 1999

Barry PH, 1999, 'Glycine receptors: What gets in and why?', in Proceedings of Aust Neuroscience Society, 19th Annual Meeting Australian Neuroscience Society, University of Tasmania, Hobart, pp. 17, presented at 19th Annual Meeting Australian Neuroscience Society, University of Tasmania, Hobart, 31 January - 03 February 1999

Barry PH; Balasubramanian S; Lynch JW, 1998, 'Ion permeation through cyclic nucleotide-gated channels in olfactory receptor neurons', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 51, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Moorhouse AJ; Keramidas A; Barry PH; Schofield PR, 1998, 'Molecular determinants of ligand-gated ion channel conductance: studies using cystein mutagenesis', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 56, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Keramidas A; Kuhlmann L; Moorhouse AJ; Barry PH, 1998, 'Measurement of limiting equivalent conductivities and mobilities of the most prevalent ionic species of EGTA [EGTA2- and EGTA3-] for use in electrophysiology', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 327, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Kaur R; Barry PH, 1998, 'Odorant-induced currents in intact-patches of rat olfactory receptor neurons', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 233, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Barry PH; Balasubramanian S; Lynch JW, 1998, 'Modelling of ion permeation and current-concentration relations for CNG channels in olfactory receptor neurons', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 234, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Fatima-Shad K; Schofield PR; Barry PH, 1998, 'Ion selectivity in homomeric glycine receptor channels', in Proceedings of the Australian Physiological and Pharmacological Society, 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, pp. 58, presented at 66th Meeting of Physiology and Pharmacology Society, Brisbane, Qld, 27 September - 01 October 1998

Moorhouse AJ; Keramidas A; Barry PH; Schofield PR, 1998, 'Molecular determinants of ligand-gated ion channel conductance: studies using cystein mutagenesis', in Australian Society of Medical research, Australian Society of Medical research, Garvan Institute, Sydney, pp. 212, presented at Australian Society of Medical research, Garvan Institute, Sydney, 01 June 1997

Barry PH; Balasubramanian S; Hallani M; Lynch JW, 1998, 'Permeation through ion channels in excised patches from the dendritic knob of olfactory receptor neurons', in Australian Society of Medical research, Australian Society of Medical research, Garvan Institute, Sydney, pp. 202, presented at Australian Society of Medical research, Garvan Institute, Sydney, 01 June 1997

Fatima-Shad K; Barry PH; Schofield PR, 1998, 'Anion Permeation through glycine receptor channels in tranfected cells and cultured hippocampal neurons', in Proceedings of Aust Neuroscience Society, 18th Annual meeting Australian Neuroscience Society, Canberra, pp. 89, presented at 18th Annual meeting Australian Neuroscience Society, Canberra, 27 - 30 January 1998

Moorhouse AJ; Barry PH; Schofield PR, 1997, 'The Startle disease mutation Q266H impairs the gating of recombinant human glycine receptors', in Proceedings of the Australian Physiological and Pharmacological Society, 65th Meeting of Physiology and Pharmacology Society, Adelaide, Sth Aust, pp. 44P - 44P, presented at 65th Meeting of Physiology and Pharmacology Society, Adelaide, Sth Aust, 28 September - 01 October 1997

Moorhouse AJ; Pierce K; Lynch JW; Barry PH; Schofield PR, 1997, 'The effects of the Startle disease mutation Q266H on recombinant human glycine receptors', in Proceedings of Aust Neuroscience Society, 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, pp. 38 - 38, presented at 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, 01 - 04 February 1996

Barry PH, 1997, 'An analysis of currents across cell-attached patches in response to cell perfusion by channel- or potential-altering compounds.', in Proceedings of the Australian Physiological and Pharmacological Society, 65th Meeting of Physiology and Pharmacology Society, Adelaide, Sth Aust, pp. 51P, presented at 65th Meeting of Physiology and Pharmacology Society, Adelaide, Sth Aust, 28 September - 01 October 1997

Fatima-Shad K; Barry PH, 1997, 'Rate theory modelling of ionic conductances through GABA and glycine receptor channels in mammalian cultured hippocampal neurons.', in 33rd International Union Physiological society, 33rd International Union Physiological society, St Petersberg, pp. POO2.03, presented at 33rd International Union Physiological society, St Petersberg, 30 June - 05 July 1997

Barry PH; Balasubramanian S; Lynch JW, 1997, 'Modelling concentration dependence of sodium permeation through CNG channels of rat olfactory receptor neurons.', in 33rd International Union Physiological society, 33rd International Union Physiological society, St Petersberg, pp. POO2.10, presented at 33rd International Union Physiological society, St Petersberg, 30 June - 05 July 1997

Barry PH; Chiu P; Lynch JW, 1997, 'An analysis of odorant-induced currents in ion-cell patches on mammalian olfactory receptor neurons.', in Chemical Senses, Oxford Univ Press, Oxford, England, pp. 644, presented at Chemical Senses 1997, 01 January 1997

Balasubramanian S; Lynch JW; Barry PH, 1997, 'Effects of concentration on sodium permeation and ion interactions in CNG channels of rat olfactory receptor neurons.', in Chemical Senses, Oxford Univ Press, Oxford, England, pp. 643, presented at Chemical Senses 1997, 01 January 1997

Hallini M; Lynch JW; Barry PH, 1997, 'Characterisation of Ca2+-activated Cl- channels in excised inside-out patches of mammalian olfactory receptor neurons.', in Proceedings of Aust Neuroscience Society, 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, pp. 38, presented at 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, 01 - 04 February 1996

Balasubramanian S; Lynch JW; Barry PH, 1997, 'Cation permeation in the cAMP-gated channels of mammalian olfactory receptor neurons: concentration dependence and cation.', in Proceedings of Aust Neuroscience Society, 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, pp. 39, presented at 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, 01 - 04 February 1996

Barry PH; Chiu P; Lynch JW, 1997, 'An analysis of measurements of odorant-induced currents in cell-attached patches on small mammalian olfactory receptor neurons.', in Proceedings of Aust Neuroscience Society, 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, pp. 40, presented at 16th Annual Meeting of the Australian Neuroscience Society, University of Adelaide, 01 - 04 February 1996

Software / Code

Conference Posters

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'Experimental and theoretical validation of calculated liquid junction potentials in monovalent ion solutions and effects of divalent ions', in Experimental and theoretical validation of calculated liquid junction potentials in monovalent ion solutions and effects of divalent ions, 37th Annual Meeting of the Australian Society for Biophysics, RMIT, Melbourne, presented at 37th Annual Meeting of the Australian Society for Biophysics, RMIT, Melbourne, 24 - 27 November 2013

Tam D; Windley MJ; Drwal M; Moorhouse AJ; Barry PH; Lewis TM, 2013, 'Subunit interface interactions involved in the signal transduction of the glycine receptor', in Subunit interface interactions involved in the signal transduction of the glycine receptor, 37th Annual Meeting of the Australian Society for Biophysics, RMIT, Melbourne, presented at 37th Annual Meeting of the Australian Society for Biophysics, RMIT, Melbourne, 24 - 27 November 2013

Barry PH; Lewis TM; Moorhouse AJ, 2013, 'Experimental and theoretical validation of calculated liquid junction potentials in monovalent ion solutions and effects of divalent ions', in Experimental and theoretical validation of calculated liquid junction potentials in monovalent ion solutions and effects of divalent ions, 37th Annual Conference of the Australian Society for Biophysics, Melbourne, presented at 37th Annual Conference of the Australian Society for Biophysics, Melbourne, 24 - 27 November 2013

Barry PH; Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ, 2009, 'DO DIVALENT CATIONS INCREASE THE ANION-CATION PERMEABILITY IN GLYCINE RECEPTOR CHANNELS, EVEN WITH INITIAL OFFSET AND ACTIVITY CORRECTIONS?', in JOURNAL OF PHYSIOLOGICAL SCIENCES, SPRINGER TOKYO, Vol. 59, pp. 393 - 393, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271023102616&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Moorhouse A; Carland JE; Cooper MA; Sugiharto S; Jeong H-J; Lewis TM; Barry PH; Peters JA; Lambert JJ, 2009, 'MOLECULAR DETERMINANTS OF ION PERMEATION IN GLYCINE RECEPTOR-CHANNELS: CHARACTERISING CHARGED RESIDUES IN THE INTRACELLULAR M3-M4 LOOP', in JOURNAL OF PHYSIOLOGICAL SCIENCES, SPRINGER TOKYO, Vol. 59, pp. 393 - 393, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000271023102614&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Presentations

Barry PH; Lewis TM; Moorhouse AJ, 2014, 'An experimental validation of calculated liquid junction potentials for monovalent ion solutions and problems that can arise with solutions of mixtures of different ion valencies', in An experimental validation of calculated liquid junction potentials for monovalent ion solutions and problems that can arise with solutions of mixtures of different ion valencies, International Union of Pure and Applied Biophysics Congress, Brisbane, Qld, Australia, presented at International Union of Pure and Applied Biophysics Congress, Brisbane, Qld, Australia, 03 - 07 August 2014

Barry PH; Lewis TM; Moorhouse AJ, 2012, 'Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology', in Further measurements of liquid junction potentials, and their implications, using a refined freshly-cut 3M KCl reference salt-bridge methodology, Joint AuPS-ASB-PNZ meeting, UNSW, NSW, Australia, presented at Joint AuPS-ASB-PNZ meeting, UNSW, NSW, Australia, 02 - 05 December 2012, http://www.aups.org.au/Proceedings/43/61P

Barry PH; Lewis TM; Moorhouse AJ, 2011, 'An improved method, with theoretical analysis, for the simple experimental measurement of liquid junction potentials', in An improved method, with theoretical analysis, for the simple experimental measurement of liquid junction potentials, Joint ASB-BioPhysChem 2011 Conference, University of Wollongong, NSW, Australia, presented at Joint ASB-BioPhysChem 2011 Conference, University of Wollongong, NSW, Australia, 03 - 06 December 2011

Barry PH; Sugiharto S; Carland JE; Lewis TM; Moorhouse AJ, 2009, 'The lack of certain activity corrections and initial offset corrections can produce erroneous anion-cation permeability ratios in GlyR channels', in The lack of certain activity corrections and initial offset corrections can produce erroneous anion-cation permeability ratios in GlyR channels, Curtin Conference, RMIT, Melbourne, VIC, presented at Curtin Conference, RMIT, Melbourne, VIC, 15 - 17 April 2009

Barry PH; Sugiharto S; Carland JE; Moorhouse AJ; Lewis TM, 2009, 'Permeability measurements in anion channels: effects of divalent cations, liquid junction potentials and offsets', in Permeability measurements in anion channels: effects of divalent cations, liquid junction potentials and offsets, 33rd Annual Meeting of the Australian Society for Biophysics, Ballarat, NSW, Australia, presented at 33rd Annual Meeting of the Australian Society for Biophysics, Ballarat, NSW, Australia, 29 November 2009

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