Dr Yazi Ke
Tabs
Publications related to this Person
Book Chapters
Ittner LM; Lee WS; Stefanoska K; Asih PR; Ke YD, 2018, 'Alzheimer’s Disease and Frontotemporal Lobar Degeneration: Mouse Models', in NeurodegeneratIve Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, pp. 187 - 219, http://dx.doi.org/10.1007/978-3-319-72938-1_10
Van Eersel J; Delerue F; Ittner LM; Ke YD, 2014, 'Alzheimer's disease and frontotemporal lobar degeneration: Mouse models', in Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers, pp. 111 - 129, http://dx.doi.org/10.1007/978-1-4471-6380-0_8
Journal articles
Ke YD; Ittner LM, 2018, 'Epothilone D – correct drug, wrong disease', Neuropathology and Applied Neurobiology, vol. 44, pp. 548 - 549, http://dx.doi.org/10.1111/nan.12478
Martin AD; Chua SW; Au CG; Stefen H; Przybyla M; Lin Y; Bertz J; Thordarson P; Fath T; Ke YD; Ittner LM, 2018, 'Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons', ACS Applied Materials and Interfaces, vol. 10, pp. 25127 - 25134, http://dx.doi.org/10.1021/acsami.8b07560
van Hummel A; Chan G; van der Hoven J; Morsch M; Ippati S; Suh L; Bi M; Asih PR; Lee WS; Butler TA; Przybyla M; Halliday GM; Piguet O; Kiernan MC; Chung RS; Ittner LM; Ke YD, 2018, 'Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice', American Journal of Pathology, vol. 188, pp. 1447 - 1456, http://dx.doi.org/10.1016/j.ajpath.2018.03.002
Ahmed RM; Ke YD; Vucic S; Ittner LM; Seeley W; Hodges JR; Piguet O; Halliday G; Kiernan MC, 2018, 'Physiological changes in neurodegeneration-mechanistic insights and clinical utility', Nature Reviews Neurology, vol. 14, pp. 259 - 271, http://dx.doi.org/10.1038/nrneurol.2018.23
Stefanoska K; Volkerling A; Bertz J; Poljak A; Ke YD; Ittner LM; Ittner A, 2018, 'An N-terminal motif unique to primate tau enables differential protein–protein interactions', Journal of Biological Chemistry, vol. 293, pp. 3710 - 3719, http://dx.doi.org/10.1074/jbc.RA118.001784
Tan DCS; Yao S; Ittner A; Bertz J; Ke YD; Ittner LM; Delerue F, 2018, 'Generation of a New Tau Knockout (tau Δex1) Line Using CRISPR/Cas9 Genome Editing in Mice', Journal of Alzheimer's Disease, vol. 62, pp. 571 - 578, http://dx.doi.org/10.3233/JAD-171058
Bi M; Gladbach A; Van Eersel J; Ittner A; Przybyla M; Van Hummel A; Chua SW; Hoven JVD; Lee WS; Müller J; Parmar J; Jonquieres GV; Stefen H; Guccione E; Fath T; Housley GD; Klugmann M; Ke YD; Ittner LM, 2017, 'Tau exacerbates excitotoxic brain damage in an animal model of stroke', Nature Communications, vol. 8, http://dx.doi.org/10.1038/s41467-017-00618-0
Moujalled D; Grubman A; Acevedo K; Yang S; Ke YD; Moujalled DM; Duncan C; Caragounis A; Perera ND; Turner BJ; Prudencio M; Petrucelli L; Blair I; Ittner LM; Crouch PJ; Liddell JR; White AR, 2017, 'TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway', Human Molecular Genetics, vol. 26, pp. 1732 - 1746, http://dx.doi.org/10.1093/hmg/ddx093
Ahmed RM; Irish M; van Eersel J; Ittner A; Ke YD; Volkerling A; van der Hoven J; Tanaka K; Karl T; Kassiou M; Kril JJ; Piguet O; Götz J; Kiernan MC; Halliday GM; Hodges JR; Ittner LM, 2017, 'Mouse models of frontotemporal dementia: A comparison of phenotypes with clinical symptomatology', Neuroscience and Biobehavioral Reviews, vol. 74, pp. 126 - 138, http://dx.doi.org/10.1016/j.neubiorev.2017.01.004
Ittner A; Chua SW; Bertz J; Volkerling A; van der Hoven J; Gladbach A; Przybyla M; Bi M; van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva APG; Mackay JP; Poljak A; Delerue F; Ke YD; Ittner LM, 2017, 'Site-specific phosphorylation of tau inhibits amyloid-beta toxicity in Alzheimer's mice (vol 354, 904, 2016)', SCIENCE, vol. 355, http://dx.doi.org/10.1126/science.aam9523
Tan RH; Ke YD; Ittner LM; Halliday GM, 2017, 'ALS/FTLD: experimental models and reality', Acta Neuropathologica, vol. 133, pp. 177 - 196, http://dx.doi.org/10.1007/s00401-016-1666-6
Rosa E; Mahendram S; Ke YD; Ittner LM; Ginsberg SD; Fahnestock M, 2016, 'Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease', Neurobiology of Aging, vol. 48, pp. 135 - 142, http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.020
Ittner A; Chua SW; Bertz J; Volkerling A; Van Der Hoven J; Gladbach A; Przybyla M; Bi M; Van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva APG; Mackay J; Poljak A; Delerue F; Ke YD; Ittner LM, 2016, 'Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice', Science, vol. 354, pp. 904 - 908, http://dx.doi.org/10.1126/science.aah6205
Van Hummel A; Bi M; Ippati S; Van Der Hoven J; Volkerling A; Lee WS; Tan DCS; Bongers A; Ittner A; Ke YD; Ittner LM, 2016, 'No overt deficits in aged tau-deficient C57Bl/6.Mapttm1(EGFP)kit GFP knockin mice', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0163236
Przybyla M; Stevens CH; van der Hoven J; Harasta A; Bi M; Ittner A; van Hummel A; Hodges JR; Piguet O; Karl T; Kassiou M; Housley GD; Ke YD; Ittner LM; Eersel JV, 2016, 'Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia', Neuroscience Letters, vol. 631, pp. 24 - 29, http://dx.doi.org/10.1016/j.neulet.2016.08.007
Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836
Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM, 2015, 'Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS', Acta Neuropathologica, vol. 130, pp. 661 - 678, http://dx.doi.org/10.1007/s00401-015-1486-0
Gladbach A; Van Eersel J; Bi M; Ke YD; Ittner LM, 2014, 'ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke', Journal of Neural Transmission, vol. 121, pp. 543 - 547, http://dx.doi.org/10.1007/s00702-013-1138-2
Ke YD; Suchowerska AK; Van Der Hoven J; De Silva DM; Wu CW; Van Eersel J; Ittner A; Ittner LM, 2012, 'Lessons from Tau-deficient mice', International Journal of Alzheimer's Disease, http://dx.doi.org/10.1155/2012/873270
Ke Y; Dramiga J; Schütz U; Kril JJ; Ittner LM; Schröder H; Götz J, 2012, 'Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease.', PloS one, vol. 7, http://dx.doi.org/10.1371/journal.pone.0035678
Bi M; Ittner A; Ke YD; Götz J; Ittner LM, 2011, 'Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0026860
van Eersel J; Ke YD; Gladbach A; Bi M; Götz J; Kril JJ; Ittner LM, 2011, 'Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0022850
Ittner A; Ke YD; Van Eersel J; Gladbach A; Götz J; Ittner LM, 2011, 'Brief update on different roles of tau in neurodegeneration', IUBMB Life, vol. 63, pp. 495 - 502, http://dx.doi.org/10.1002/iub.467
Van Eersel J; Ke YD; Liu X; Delerue F; Kril JJ; Götz J; Ittner LM, 2010, 'Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, pp. 13888 - 13893, http://dx.doi.org/10.1073/pnas.1009038107
Götz J; Lim YA; Ke YD; Eckert A; Ittner LM, 2010, 'Dissecting Toxicity of Tau and β-Amyloid', Neurodegenerative Diseases, vol. 7, pp. 10 - 12, http://dx.doi.org/10.1159/000283475
Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, vol. 142, pp. 387 - 397, http://dx.doi.org/10.1016/j.cell.2010.06.036
Schonrock N; Yazi DK; Humphreys D; Staufenbiel M; Ittner LM; Preiss T; Gotz J, 2010, 'Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta', PLoS One, vol. 5, pp. e11070, http://dx.doi.org/10.1371/journal.pone.0011070
Ke YD; Delerue F; Gladbach A; Götz J; Ittner LM, 2009, 'Experimental diabetes mellitus exacerbates Tau pathology in a transgenic mouse model of Alzheimer's disease', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0007917
Ittner LM; Ke YD; Götz J, 2009, 'Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease', Journal of Biological Chemistry, vol. 284, pp. 20909 - 20916, http://dx.doi.org/10.1074/jbc.M109.014472
Fath T; Ke YD; Gunning P; Gotz J; Ittner LM, 2009, 'Primary support cultures of hippocampal and substantia nigra neurons', Nature Protocols, vol. 4, pp. 78 - 85, http://dx.doi.org/10.1038/nprot.2008.199
Van Eersel J; Bi M; Ke Y; Hodges JR; Xuereb J; Gregory GC; Halliday GM; Gotz J; Kril J; Ittner L, 2009, 'Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains', Journal of Neural Transmission, vol. 116, pp. 1243 - 1251, http://dx.doi.org/10.1007/s00702-009-0293-y
Gotz J; David D; Hoerndli F; Ke YD; Schonrock N; Weisner A; Fath T; Bokhari L; Lim Y-A; Deters N; Ittner LM, 2008, 'Functional Genomics Dissects Pathomechanisms in Tauopathies: Mitosis Failure and Unfolded Protein Response', Neurodegenerative Diseases, vol. 5, pp. 179 - 181, http://dx.doi.org/10.1159/000113696
Ittner LM; Fath T; Ke YD; Bi M; van Eersel J; Li KM; Gunning P; Gotz J, 2008, 'Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia', Proceedings of the National Academy of Sciences of the United States of America, vol. 105, pp. 15997 - 16002, http://dx.doi.org/10.1073/pnas.0808084105
Götz J; Deters N; Doldissen A; Bokhari L; Ke Y; Wiesner A; Schonrock N; Ittner LM, 2007, 'A decade of tau transgenic animal models and beyond', Brain Pathology, vol. 17, pp. 91 - 103, http://dx.doi.org/10.1111/j.1750-3639.2007.00051.x
Schild A; Schmidt K; Lim YA; Ke Y; Ittner LM; Hemmings BA; Götz J, 2006, 'Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation', International Journal of Developmental Neuroscience, vol. 24, pp. 437 - 443, http://dx.doi.org/10.1016/j.ijdevneu.2006.08.005
Conference Papers
Gladbach A; Bi M; van Eersel J; Ke Y; Ittner L, 2015, 'Tau depletion prevents brain damage in a mouse model of stroke with reperfusion', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 223 - 223, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300548&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Ittner L; Gladbach A; Ittner A; van Eersel J; Harasta A; Delerue F; Bi M; Ke Y, 2015, 'Post-synaptic functions of tau in Alzheimer's disease', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, pp. 31 - 31, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300058&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1