Dr Nicole Jones | Brain Sciences UNSW

Tabs

Main

University role:

Senior Lecturer

Phone:

+61 2 9385 2568

Email:

n.jones@unsw.edu.au

Research Interests:
The broad research focus of the lab is to examine cellular and molecular mechanisms that may cause or prevent brain cell death resulting from an acute brain injury (ie perinatal asphyxia, stroke, trauma). Drugs with neuroprotective potential are routinely investigated in cell lines, brain tissue cultures and in vivo rat injury models as part of a search for new therapeutic strategies for acute brain injuries. Because tissue hypoxia often occurs after a brain insult, we are interested in learning how hypoxia-inducible proteins (hypoxia-inducible factor-1 (HIF-1), erythropoietin, vascular endothelial growth factor, glucose transporters) are involved in injury and repair processes of the brain.

Broad Research Areas:
Neuroscience, Injury, Pharmacology

Qualifications:
BSc (Hons), PhD

Society Memberships & Professional Activities:
Society for Neuroscience - USA (SFN), Australian Society for Medical Research (ASMR), Australian Neuroscience Society (ANS), Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT), International society for Cerebral Blood Flow and Metabolism (ICBFM)

Specific Research Keywords:
Hypoxia, Stroke, Neuroprotection, Neuropharmacology, Brain injury and repair

Research

Publications related to this Person

Book Chapters

Polly P; Vickery R; Thai T; Yang JL; Fath T; Herbert C; Jones N; Lewis T; Pather N; Schibeci S, 2016, 'ePortfolios, assessment and professional skills in the medical sciences', in ePortfolios in Australian Universities, pp. 47 - 64, http://dx.doi.org/10.1007/978-981-10-1732-2_4

Jones NM; Galle AA, 2013, 'Preconditioning and neuroprotection in the immature brain', in Innate Tolerance in the CNS: Translational Neuroprotection by Pre- and Post-Conditioning, pp. 259 - 268, http://dx.doi.org/10.1007/978-1-4419-9695-4_12

Jones N; Galle A, 2012, 'Preconditioning and neuroprotection in the immature brain', in Gidday JM; Perez-Pinzon M; Zhang JH (ed.), Innate Tolerance in the CNS: Translational Neuroprotection by Pre- and Post-Conditioning, edn. 1st, Springer, pp. 259 - 268, http://dx.doi.org/10.1007/978-1-4419-9695-4

Mercer LD; Nunan J; Jones NM; Lawrence AJ; Cheung NS; Mercer JFB; Firth SD; Thompson P; Jarrott B; Finkelstein DI, 1999, 'Immunohistochemistry with antibodies to the cholecystokinin-A receptor reveals a widespread distribution in rat and monkey central nervous system', in Geppetti P; MullerEsterl W; Regoli D (ed.), PEPTIDERGIC G PROTEIN-COUPLED RECEPTORS, edn. NATO ADVANCED SCIENCE INSTITUTES SERIES, SERIES A, LIFE SCIE, I O S PRESS, ERICE, ITALY, pp. 175 - 180, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000079605500020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Journal articles

Teo JD; Morris MJ; Jones NM, 2017, 'Hypoxic postconditioning improves behavioural deficits at 6 weeks following hypoxic-ischemic brain injury in neonatal rats', Behavioural Brain Research, vol. 333, pp. 27 - 34, http://dx.doi.org/10.1016/j.bbr.2017.06.036

Chan YL; Saad S; Al-Odat I; Oliver BG; Pollock C; Jones NM; Chen H, 2017, 'Maternal L-carnitine supplementation improves brain health in offspring from cigarette smoke exposed mothers', Frontiers in Molecular Neuroscience, vol. 10, http://dx.doi.org/10.3389/fnmol.2017.00033

Teo JD; Morris MJ; Jones NM, 2017, 'Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats', Brain, Behavior, and Immunity, vol. 63, pp. 186 - 196, http://dx.doi.org/10.1016/j.bbi.2016.10.010

Chan YL; Saad S; Al-Odat I; Zaky AA; Oliver B; Pollock C; Li W; Jones NM; Chen H, 2016, 'Impact of maternal cigarette smoke exposure on brain and kidney health outcomes in female offspring', Clinical and Experimental Pharmacology and Physiology, vol. 43, pp. 1168 - 1176, http://dx.doi.org/10.1111/1440-1681.12659

Yang JL; Polly P; Fath T; Jones N; Power J, 2016, 'ISA model and integrative career development learning in year three science courses', International Journal of Science, Mathematics and Technology Learning, vol. 23, pp. 33 - 49

Chan YL; Saad S; Pollock C; Oliver B; Al-Odat I; Zaky AA; Jones N; Chen H, 2016, 'Impact of maternal cigarette smoke exposure on brain inflammation and oxidative stress in male mice offspring', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep25881

Coleman JLJ; Ngo T; Schmidt J; Mrad N; Liew CK; Jones NM; Graham RM; Smith NJ, 2016, 'Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity', Science Signaling, vol. 9, http://dx.doi.org/10.1126/scisignal.aad1089

Lizarme Y; Wangsahardja J; Marcolin GM; Morris JC; Jones NM; Hunter L, 2016, 'Synthesis and neuroprotective activity of dictyoquinazol A and analogues', Bioorganic and Medicinal Chemistry, vol. 24, pp. 1480 - 1487, http://dx.doi.org/10.1016/j.bmc.2016.02.016

Chu HX; Jones NM, 2016, 'Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic–Ischemic Injury in the Neonatal Rat', Neurochemical Research, vol. 41, pp. 515 - 522, http://dx.doi.org/10.1007/s11064-015-1641-y

Teo JD; Morris MJ; Jones NM, 2015, 'Hypoxic postconditioning reduces microglial activation, astrocyte and caspase activity, and inflammatory markers after hypoxia-ischemia in the neonatal rat brain', Pediatric Research, vol. 77, pp. 757 - 764, http://dx.doi.org/10.1038/pr.2015.47

Parmar J; Jones NM, 2015, 'Hypoxic preconditioning can reduce injury-induced inflammatory processes in the neonatal rat brain', International Journal of Developmental Neuroscience, vol. 43, pp. 35 - 42, http://dx.doi.org/10.1016/j.ijdevneu.2015.03.010

Suryana E; Jones NM, 2014, 'The effects of hypoxic preconditioning on white matter damage following hypoxic-ischaemic injury in the neonatal rat brain', International Journal of Developmental Neuroscience, vol. 37, pp. 69 - 75, http://dx.doi.org/10.1016/j.ijdevneu.2014.06.007

Galle AA; Jones NM, 2013, 'The neuroprotective actions of hypoxic preconditioning and postconditioning in a neonatal rat model of hypoxic-ischemic brain injury', Brain Research, vol. 1498, pp. 1 - 8, http://dx.doi.org/10.1016/j.brainres.2012.12.026

Chu PWY; Beart PM; Jones NM, 2010, 'Preconditioning protects against oxidative injury involving hypoxia-inducible factor-1 and vascular endothelial growth factor in cultured astrocytes', European Journal of Pharmacology, vol. 633, pp. 24 - 32, http://dx.doi.org/10.1016/j.ejphar.2010.02.008

Jones NM; Kardashyan L; Callaway JK; Lee EM; Beart PM, 2008, 'Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats', Pediatric Research, vol. 63, pp. 620 - 624, http://dx.doi.org/10.1203/PDR.0b013e31816d9117

Weston RM; Jones NM; Jarrott B; Callaway JK, 2007, 'Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: Histochemical and myeloperoxidase correlation with temporal changes in brain injury', Journal of Cerebral Blood Flow and Metabolism, vol. 27, pp. 100 - 114, http://dx.doi.org/10.1038/sj.jcbfm.9600324

Cimarosti H; O'Shea RD; Jones NM; Horn AP; Simão F; Zamin LL; Nassif M; Frozza R; Netto CA; Beart PM, 2006, 'The effects of estradiol on estrogen receptor and glutamate transporter expression in organotypic hippocampal cultures exposed to oxygen-glucose deprivation', Neurochemical Research, vol. 31, pp. 483 - 490, http://dx.doi.org/10.1007/s11064-006-9043-9

O'Shea RD; Lau CL; Farso MC; Diwakarla S; Zagami CJ; Svendsen BB; Feeney SJ; Callaway JK; Jones NM; Pow DV, 2006, 'Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: Evidence for delayed up-regulation and redistribution of GLT-1', Neurochemistry International, vol. 48, pp. 604 - 610, http://dx.doi.org/10.1016/j.neuint.2005.12.028

Jones NM; Lee EM; Brown TG; Jarrott B; Beart PM, 2006, 'Hypoxic preconditioning produces differential expression of hypoxia-inducible factor-1α (HIF-1α) and its regulatory enzyme HIF prolyl hydroxylase 2 in neonatal rat brain', Neuroscience Letters, vol. 404, pp. 72 - 77, http://dx.doi.org/10.1016/j.neulet.2006.05.049

Gresle MM; Jarrott B; Jones NM; Callaway JK, 2006, 'Injury to axons and oligodendrocytes following endothelin-1-induced middle cerebral artery occlusion in conscious rats', Brain Research, vol. 1110, pp. 13 - 22, http://dx.doi.org/10.1016/j.brainres.2006.06.111

Cimarosti H; Jones NM; O'Shea RD; Pow DV; Salbego C; Beart PM, 2005, 'Hypoxic preconditioning in neonatal rat brain involves regulation of excitatory amino acid transporter 2 and estrogen receptor alpha', Neuroscience Letters, vol. 385, pp. 52 - 57, http://dx.doi.org/10.1016/j.neulet.2005.05.006

Jones NM; Bergeron M, 2004, 'Hypoxia-induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling', Journal of Neurochemistry, vol. 89, pp. 157 - 167, http://dx.doi.org/10.1111/j.1471-4159.2004.02324.x

Jones NM; Bergeron M, 2001, 'Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain', Journal of Cerebral Blood Flow and Metabolism, vol. 21, pp. 1105 - 1114, http://dx.doi.org/10.1097/00004647-200109000-00008

Bond A; Jones NM; Hicks CA; Whiffin GM; Ward MA; O'Neill MF; Kingston AE; Monn JA; Ornstein PL; Schoepp DD, 2000, 'Neuroprotective Effects of LY379268, a Selective mGlu2/3 Receptor Agonist: Investigations into Possible Mechanism of Action In Vivo', Journal of Pharmacology and Experimental Therapeutics, vol. 294, pp. 800 - 809

Mercer LD; Le VQ; Nunan J; Jones NM; Beart PM, 2000, 'Direct visualization of cholecystokinin subtype2 receptors in rat central nervous system using anti-peptide antibodies', Neuroscience Letters, vol. 293, pp. 167 - 170, http://dx.doi.org/10.1016/S0304-3940(00)01504-4

Jones NM; Beart PM; Monn JA; Widdop RE, 1999, 'Type I and II metabotropic glutamate receptors mediate depressor and bradycardic actions in the nucleus of the solitary tract of anaesthetized rats', European Journal of Pharmacology, vol. 380, pp. 129 - 135, http://dx.doi.org/10.1016/S0014-2999(99)00518-X

Li XC; Beart PM; Monn JA; Jones NM; Widdop RE, 1999, 'Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats', British Journal of Pharmacology, vol. 128, pp. 823 - 829, http://dx.doi.org/10.1038/sj.bjp.0702850

Jones NM; Lawrence AJ; Beart PM, 1998, 'In vivo microdialysis reveals facilitatory metabotropic glutamate receptors regulating excitatory amino acid release in rat nucleus tractus solitarius', Neurochemistry International, vol. 32, pp. 31 - 38, http://dx.doi.org/10.1016/S0197-0186(97)00050-8

Jones NM; Monn JA; Beart PM, 1998, 'Type I and II metabotropic glutamate receptors regulate the outflow of [3H]d-aspartate and [14C]γ-aminobutyric acid in rat solitary nucleus', European Journal of Pharmacology, vol. 353, pp. 43 - 51, http://dx.doi.org/10.1016/S0014-2999(98)00394-X

Jones NM; Loiacono RE; Beart PM, 1995, 'Roles for Nitric Oxide as an Intra‐ and Interneuronal Messenger at NMDA Release‐Regulating Receptors: Evidence from Studies of the NMDA‐Evoked Release of [³H]Noradrenaline and d‐[^{3Journal of Neurochemistry, vol. 64, pp. 2057 - 2063, http://dx.doi.org/10.1046/j.1471-4159.1995.64052057.x}

Møller M; Jones NM; Beart PM, 1995, 'Complex involvement of nitric oxide and cGMP at N-methyl-d-aspartic acid receptors regulating γ-[³H]aminobutyric acid release from striatal slices', Neuroscience Letters, vol. 190, pp. 195 - 198, http://dx.doi.org/10.1016/0304-3940(95)11538-8

Jones NM; Loiacono RE; Møller M; Beart PM, 1994, 'Diverse roles for nitric oxide in synaptic signalling after activation of NMDA release-regulating receptors', Neuropharmacology, vol. 33, pp. 1351 - 1356, http://dx.doi.org/10.1016/0028-3908(94)90036-1

Conference Papers

Sandow SL; Jones NM; Nguyen HL; Ellinsworth D; Grayson TH; Grimley R; Dettrick A; Murphy TV, 2015, 'Endothelial BKCa, but not TRPV4 activity is altered in focal cerebral ischemic stroke', in Allen DG; Davey DF (eds.), Proceedings of the Australian Physiology Society, Australian Physiology Society, Hobart, pp. 59P - 59P, presented at Australian Physiology Society Meeting 2015, Hobart, 29 November - 02 December 2015, http://aups.org.au/Proceedings/46/59P/

Sandow SL; Jones NM; Nguyen HL; Grayson TH; Murphy TV, 2014, 'Acute hypoxia and focal cerebral ischemia result in endothelial BKCaα and β1 protein expression in intact adult rat middle cerebral artery endothelium', in Morris B (ed.), State of the Heart 2014, International Society of cardiovascular Pharmacotherapy, Adelaide, pp. 105 - 105, presented at Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy, Adelaide, 26 - 28 November 2014, http://www.hbprca.com.au/wp-content/uploads/SoTH_Workbook_FINAL_lowRes.pdf

Sandow S; Jones NM; Nguyen HL; Grayson TH; Murphy T, 2014, 'Focal cerebral ischemia and acute hypoxia increase the expression of endothelial BKCa alpha and beta 1 protein in intact middle cerebral artery of the adult rat', in JOURNAL OF VASCULAR RESEARCH, KARGER, Banff, CANADA, pp. 122 - 122, presented at 11th International Symposium on Resistance Arteries from Molecular Machinery to Clinical Challenges, Banff, CANADA, 07 - 11 September 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000346236200104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Posters

Conference Presentations

Sandow SL; Nguyen HL; Ellinsworth DC; Grayson TH; Jones NM; Murphy TV, 2016, 'Increased BKCa and TRPV4 expression, and decreased caveolae density in distal middle cerebral artery endothelium and smooth muscle in focal cerebral ischemic stroke', in Increased BKCa and TRPV4 expression, and decreased caveolae density in distal middle cerebral artery endothelium and smooth muscle in focal cerebral ischemic stroke, Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, presented at Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, 07 - 10 December 2016

Sandow SL; Lucque N; Nguyen HL; Grayson TH; Russell FD; Hinkley V; Jones NM; Murphy TV, 2016, 'Ischemic stroke results in loss of cerebral artery endothelial and smooth muscle connexin (Cx) 37, and altered expression of Cx40, but not Cxs32 and 43', in Ischemic stroke results in loss of cerebral artery endothelial and smooth muscle connexin (Cx) 37, and altered expression of Cx40, but not Cxs32 and 43, Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, presented at Joint meeting of the Australian Vascular Biology and Atherosclerosis Societies and High Blood Pressure Research Council, Hobart, 07 - 10 December 2016

Sandow SL; Jones NM; Nguyen HL; Ellinsworth D; Grayson TH; Grimley R; Dettrick A; Murphy TV, 2015, 'Focal cerebral ischemic stroke results in endothelial BKCa expression and altered function, with no change in TRPV4 function, in middle cerebral artery', in Focal cerebral ischemic stroke results in endothelial BKCa expression and altered function, with no change in TRPV4 function, in middle cerebral artery, Proceedings of the World Congress for Microcirculation, Kyoto, presented at Proceedings of the World Congress for Microcirculation, Kyoto, 25 - 27 September 2015

Sandow SL; Jones NM; Nguyen HL; Grayson TH; Murphy TV, 2014, 'Acute hypoxia and focal cerebral ischemia result in endothelial BKCaα and β1 protein expression in intact adult rat middle cerebral artery endothelium.', in Acute hypoxia and focal cerebral ischemia result in endothelial BKCaα and β1 protein expression in intact adult rat middle cerebral artery endothelium., Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy, Adelaide, presented at Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy, Adelaide, 26 - 28 November 2014, http://www.hbprca.com.au/wp-content/uploads/SoTH_Workbook_FINAL_lowRes.pdf

Jones NM, 2010, 'ROLES FOR HYPOXIA-INDUCIBLE FACTOR-1 (HIF-1) IN BRAIN PROTECTION AND PLASTICITY', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, Vol. 115, pp. 12 - 12, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281812600024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Abstracts

Murphy TV; Nguyen HL; Grayson TH; Jones NM; Sandow SL, 2016, 'Effect of focal cerebral ischemia on BKCa and TRPV4 in rat middle cerebral artery', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, Vol. 30, presented at Experimental Biology Meeting, San Diego, CA, 02 - 06 April 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406444706032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Cunningham A; Ward M; Joshi A; Jones N, 2015, 'Dynamic alterations in VEGF receptor 3 expression following hypoxic-ischaemic injury in neonatal rat brain', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, Cairns, AUSTRALIA, Vol. 134, pp. 291 - 291, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australa, Cairns, AUSTRALIA, 23 - 27 August 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300734&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

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