Dr Claire Shepherd | Brain Sciences UNSW

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Main

University role:

Conjoint Senior Lecturer

Phone:

+61 2 93991090

Email:

c.shepherd@neura.edu.au

Dr Claire Shepherd trained in neuroscience and completed her PhD in Alzheimer’s disease at the University of Sheffield, UK. After completing her PhD she relocated to Sydney to pursue her interest in the role of inflammation in the neurodegenerative process. Soon after her move, Claire was awarded the prestigious Rolf Edgar Lake Fellowship from the University of Sydney and subsequently directed a National Health and Medical Research Council (NHMRC) project grant as CIA. In 2000 Claire was awarded the inaugural Franz Nissl Young Investigator Prize in Neuroscience in recognition of achievements in her early post-doctoral years. Since that time, she has attracted over $1.6million in research funds and now manages the Sydney Brain Bank, which is a research facility that collects, characterises and stores brain tissue for research into neurodegenerative disease. Claire is currently co-CI on an NHMRC project grant and continues to supervise undergraduate and postgraduate students within Professor Halliday’s laboratory.

Claire’s research investigating inflammatory processes in neurodegenerative disorders, such as Alzheimer’s disease (AD), dementia with Lewy bodies, Parkinson’s disease and frontotemporal dementia, has identified an association between inflammation and tau (microtubule binding protein), but not Aβ; a protein thought to be a primary stimulus for inflammation in AD. This research has also identified an association between inflammation and neuronal cell loss in these disorders. This work has received international recognition with invitations to speak at the International Congress of Neuroimmunology, International Brain Research Organisation meeting & the Australian Neuroscience Society. More recently, her research has lead to the discovery that increases in monocyte chemoattractant protein-1 drive the inflammatory process in Alzheimer’s disease and may be a target for therapeutic intervention. Claire continues to pursue her research investigating the role of inflammation in the neurodegenerative process, particularly what stimulates it, what drives it and what are the downstream consequences for neurons.

Research

Field of Research (FOR) Tag:

Neurosciences

Publications related to this Person

Book Chapters

Jeżewski RC; Halliday GM; Shepherd CE, 2021, 'The aging brain and brain banking', in Assessments, Treatments and Modeling in Aging and Neurological Disease, Elsevier, pp. 103 - 112, http://dx.doi.org/10.1016/b978-0-12-818000-6.00010-x

Gregory GC; Shepherd CE; Halliday GM, 2007, 'Physiologic and neurotoxic properties of Abeta peptides', in Barrow CJ; Small DH (ed.), Abeta Peptide and Alzheimer`s Disease, Springer Verlag, London, pp. 179 - 197, http://dx.doi.org/10.1007/978-1-84628-440-3_11

Journal articles

Amadoru S; Doré V; McLean CA; Hinton F; Shepherd CE; Halliday GM; Leyton CE; Yates PA; Hodges JR; Masters CL; Villemagne VL; Rowe CC, 2020, 'Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer's disease', Alzheimer's Research and Therapy, vol. 12, pp. 22, http://dx.doi.org/10.1186/s13195-020-00587-5

Symons GF; Clough M; Fielding J; O'Brien WT; Shepherd CE; Wright DK; Shultz SR, 2020, 'The Neurological Consequences of Engaging in Australian Collision Sports', Journal of Neurotrauma, vol. 37, pp. 792 - 809, http://dx.doi.org/10.1089/neu.2019.6884

Dobson-Stone C; Hallupp M; Shahheydari H; Ragagnin AMG; Chatterton Z; Carew-Jones F; Shepherd CE; Stefen H; Paric E; Fath T; Thompson EM; Blumbergs P; Short CL; Field CD; Panegyres PK; Hecker J; Nicholson G; Shaw AD; Fullerton JM; Luty AA; Schofield PR; Brooks WS; Rajan N; Bennett MF; Bahlo M; Shankaracharya ; Landers JE; Piguet O; Hodges JR; Halliday GM; Topp SD; Smith BN; Shaw CE; McCann E; Fifita JA; Williams KL; Atkin JD; Blair IP; Kwok JB, 2020, 'CYLD is a causative gene for frontotemporal dementia - Amyotrophic lateral sclerosis', Brain, vol. 143, pp. 783 - 799, http://dx.doi.org/10.1093/brain/awaa039

Orme T; Hernandez D; Ross OA; Kun-Rodrigues C; Darwent L; Shepherd CE; Parkkinen L; Ansorge O; Clark L; Honig LS; Marder K; Lemstra A; Rogaeva E; St. George-Hyslop P; Londos E; Zetterberg H; Morgan K; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Trojanowski JQ; Serrano GE; Beach TG; Lesage S; Galasko D; Masliah E; Santana I; Pastor P; Tienari PJ; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve BF; Petersen RC; Ferman TJ; Escott-Price V; Graff-Radford N; Cairns NJ; Morris JC; Pickering-Brown S; Mann D; Halliday G; Stone DJ; Dickson DW; Hardy J; Singleton A; Guerreiro R; Bras J, 2020, 'Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies', Acta Neuropathologica Communications, vol. 8, http://dx.doi.org/10.1186/s40478-020-0879-z

Forrest SL; Halliday GM; Sizemova A; van Roijen M; McGinley CV; Bright F; Kapur M; McGeachie AB; McCann H; Shepherd CE; Tan RH; Affleck AJ; Huang Y; Kril JJ, 2020, 'A practical approach to differentiate the frontotemporal tauopathy subtypes', Journal of Neuropathology and Experimental Neurology, vol. 79, pp. 1122 - 1126, http://dx.doi.org/10.1093/jnen/nlaa100

Jeżewski RC; Poljak A; Mather KA; Sachdev PS; Shepherd CE, 2020, 'The prevalence of limbic‐predominant age‐related TDP‐43 encephalopathy in the Sydney brain bank', Alzheimer's & Dementia, vol. 16, http://dx.doi.org/10.1002/alz.037885

Shepherd CE; McGeachie AB; Affleck AJ; Halliday GM, 2019, 'Letter to the editor', Journal of Neuropathology and Experimental Neurology, vol. 78, pp. 975, http://dx.doi.org/10.1093/jnen/nlz069

Guerreiro R; Escott-Price V; Hernandez DG; Kun-Rodrigues C; Ross OA; Orme T; Neto JL; Carmona S; Dehghani N; Eicher JD; Shepherd C; Parkkinen L; Darwent L; Heckman MG; Scholz SW; Troncoso JC; Pletnikova O; Dawson T; Rosenthal L; Ansorge O; Clarimon J; Lleo A; Morenas-Rodriguez E; Clark L; Honig LS; Marder K; Lemstra A; Rogaeva E; St. George-Hyslop P; Londos E; Zetterberg H; Barber I; Braae A; Brown K; Morgan K; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Serrano GE; Beach TG; Lesage S; Galasko D; Masliah E; Santana I; Pastor P; Diez-Fairen M; Aguilar M; Tienari PJ; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve BF; Petersen RC; Ferman TJ; Graff-Radford N; Cairns NJ; Morris JC; Pickering-Brown S; Mann D; Halliday GM; Hardy J; Trojanowski JQ; Dickson DW; Singleton A; Stone DJ; Bras J, 2019, 'Heritability and genetic variance of dementia with Lewy bodies', Neurobiology of Disease, vol. 127, pp. 492 - 501, http://dx.doi.org/10.1016/j.nbd.2019.04.004

Forrest SL; Crockford DR; Sizemova A; Mccann H; Shepherd CE; Mcgeachie AB; Affleck AJ; Carew-Jones F; Bartley L; Kwok JB; Kim WS; Jary E; Tan RH; Mcginley CV; Piguet O; Hodges JR; Kril JJ; Halliday GM, 2019, 'Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration', Neurology, vol. 92, pp. e2472 - e2482, http://dx.doi.org/10.1212/WNL.0000000000007530

Shepherd CE; Alvendia H; Halliday GM, 2019, 'Brain Banking for Research into Neurodegenerative Disorders and Ageing', Neuroscience Bulletin, vol. 35, pp. 283 - 288, http://dx.doi.org/10.1007/s12264-018-0326-3

Kun-Rodrigues C; Orme T; Carmona S; Hernandez DG; Ross OA; Eicher JD; Shepherd C; Parkkinen L; Darwent L; Heckman MG; Scholz SW; Troncoso JC; Pletnikova O; Dawson T; Rosenthal L; Ansorge O; Clarimon J; Lleo A; Morenas-Rodriguez E; Clark L; Honig LS; Marder K; Lemstra A; Rogaeva E; St. George-Hyslop P; Londos E; Zetterberg H; Barber I; Braae A; Brown K; Morgan K; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Serrano GE; Beach TG; Lesage S; Galasko D; Masliah E; Santana I; Pastor P; Diez-Fairen M; Aguilar M; Tienari PJ; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve BF; Petersen RC; Ferman TJ; Escott-Price V; Graff-Radford N; Cairns NJ; Morris JC; Pickering-Brown S; Mann D; Halliday GM; Hardy J; Trojanowski JQ; Dickson DW; Singleton A; Stone DJ; Guerreiro R; Bras J, 2019, 'A comprehensive screening of copy number variability in dementia with Lewy bodies', Neurobiology of Aging, vol. 75, pp. 223.e1 - 223.e10, http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019

Tan RH; Yang Y; McCann H; Shepherd C; Halliday GM; Whitwell J, 2019, 'Von economo neurons in behavioral variant frontotemporal dementia with underlying Alzheimer's disease', Journal of Alzheimer's Disease, vol. 69, pp. 963 - 967, http://dx.doi.org/10.3233/JAD-180900

Guerreiro R; Orme T; Neto JL; Bras J; Hardy J; Kun-Rodrigues C; Darwent L; Neto J; Carmona S; Ansorge O; Parkkinen L; Morgan K; Brown K; Braae A; Barber I; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Revesz T; Lees A; Zetterberg H; Escott-Price V; Pickering-Brown S; Mann D; Singleton A; Hernandez D; Ross O; Dickson D; Graff-Radford N; Ferman T; Petersen R; Boeve B; Heckman M; Trojanowski JQ; Van Deerlin V; Cairns N; Morris J; Stone DA; Eicher J; Clark L; Honig L; Marder K; Serrano G; Beach T; Galasko D; Masliah E; Rogaeva E; St. George-Hyslop P; Clarimon J; Lleo A; Morenas-Rodriguez E; Pastor P; Diez-Fairen M; Aquilar M; Shepherd C; Halliday G; Tienari P; Myllykangas L; Oinas M; Santana I; Lesage S; Londos E; Lemstra A, 2018, 'LRP10 in α-synucleinopathies', The Lancet Neurology, vol. 17, pp. 1032 - 1033, http://dx.doi.org/10.1016/S1474-4422(18)30399-5

Guerreiro R; Escott-Price V; Hernandez D; Kun-Rodrigues C; Ross O; Orme T; Luis Neto J; Carmona S; Dehghani N; Eicher J; Shepherd C; Parkkinen L; Darwent L; Heckman M; Scholz S; Troncoso J; Pletnikova O; Dawson T; Rosenthal L; Ansorge O; Clarimon J; Lleo A; Morenas-Rodriguez E; Clark L; Honig L; Marder K; Lemstra A; Rogaeva E; George-Hyslop PS; Londos E; Zetterberg H; Barber I; Braae A; Brown K; Morgan K; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Serrano G; Beach T; Lesage S; Galasko D; Masliah E; Santana I; Pastor P; Diez-Fairen M; Aguilar M; Tienari P; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve B; Petersen R; Ferman T; Graff-Radford N; Cairns N; Morris J; Pickering-Brown S; Mann D; Halliday G; Hardy J; Trojanowski J; Dickson D; Singleton A; Stone D; Bras J; for the International Parkinson’s Disease Genomics Consortium , 2018, 'Heritability and genetic variance of dementia with Lewy bodies', , http://dx.doi.org/10.1101/454249

Paradise M; Shepherd CE; Wen W; Sachdev PS, 2018, 'Neuroimaging and neuropathology indices of cerebrovascular disease burden: A systematic review', Neurology, vol. 91, pp. 310 - 320, http://dx.doi.org/10.1212/wnl.0000000000005997

Morales-Briceño H; Cruse B; Fois AF; Lin MW; Jiang J; Banerjee D; Grunstein R; Varikatt W; Rodriguez M; Shepherd C; Fung VSC, 2018, 'IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease', Neurology, vol. 90, pp. 1106 - 1112, http://dx.doi.org/10.1212/WNL.0000000000005679

Shepherd CE; Yang Y; Halliday GM, 2018, 'Region- and Cell-specific Aneuploidy in Brain Aging and Neurodegeneration', Neuroscience, vol. 374, pp. 326 - 334, http://dx.doi.org/10.1016/j.neuroscience.2018.01.050

Guerreiro R; Ross OA; Kun-Rodrigues C; Hernandez DG; Orme T; Eicher JD; Shepherd CE; Parkkinen L; Darwent L; Heckman MG; Scholz SW; Troncoso JC; Pletnikova O; Ansorge O; Clarimon J; Lleo A; Morenas-Rodriguez E; Clark L; Honig LS; Marder K; Lemstra A; Rogaeva E; St George-Hyslop P; Londos E; Zetterberg H; Barber I; Braae A; Brown K; Morgan K; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Serrano GE; Beach TG; Lesage S; Galasko D; Masliah E; Santana I; Pastor P; Diez-Fairen M; Aguilar M; Tienari PJ; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve BF; Petersen RC; Ferman TJ; Escott-Price V; Graff-Radford N; Cairns NJ; Morris JC; Pickering-Brown S; Mann D; Halliday GM; Hardy J; Trojanowski JQ; Dickson DW; Singleton A; Stone DJ; Bras J, 2018, 'Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study', The Lancet Neurology, vol. 17, pp. 64 - 74, http://dx.doi.org/10.1016/S1474-4422(17)30400-3

Bhatia S; Kim WS; Shepherd CE; Halliday GM, 2018, 'Apolipoprotein D Upregulation in Alzheimer’s Disease but Not Frontotemporal Dementia', Journal of Molecular Neuroscience, http://dx.doi.org/10.1007/s12031-018-1217-9

Dore V; Bourgeat P; Cummins TL; Raniga P; Williams S; Amadoru S; MacLean C; Hinton F; Shepherd C; Halliday GM; Leyton CE; Hodges JR; Ames D; Martins RN; Masters CL; Fripp J; Salvado O; Villemagne VL; Rowe C, 2018, 'IC-P-008: VISUAL ASSESSMENT OF β-AMYLOID PET SCAN IS IMPROVED BY CAPAIBL', Alzheimer's & Dementia, vol. 14, pp. P18 - P19, http://dx.doi.org/10.1016/j.jalz.2018.06.2072

Dore V; Bourgeat P; Cummins TL; Raniga P; Williams S; Amadoru S; MacLean C; Hinton F; Shepherd C; Halliday GM; Leyton CE; Hodges JR; Ames D; Martins RN; Masters CL; Fripp J; Salvado O; Villemagne VL; Rowe C, 2018, 'P1-405: VISUAL ASSESSMENT OF β-AMYLOID PET SCAN IS IMPROVED BY CAPAIBL', Alzheimer's & Dementia, vol. 14, pp. P459 - P459, http://dx.doi.org/10.1016/j.jalz.2018.06.414

Yang Y; Shepherd CE; Halliday GM, 2017, 'Increased aneuploidy is not a universal feature across α-synucleinopathies', Movement Disorders, vol. 32, pp. 475 - 476, http://dx.doi.org/10.1002/mds.26869

Kun-Rodrigues C; Ross OA; Orme T; Shepherd C; Parkkinen L; Darwent L; Hernandez D; Ansorge O; Clark LN; Honig LS; Marder K; Lemstra A; Scheltens P; van der Flier W; Louwersheimer E; Holstege H; Rogaeva E; St. George-Hyslop P; Londos E; Zetterberg H; Barber I; Braae A; Brown K; Morgan K; Maetzler W; Berg D; Troakes C; Al-Sarraj S; Lashley T; Holton J; Compta Y; Van Deerlin V; Trojanowski JQ; Serrano GE; Beach TG; Clarimon J; Lleó A; Morenas-Rodríguez E; Lesage S; Galasko D; Masliah E; Santana I; Diez M; Pastor P; Tienari PJ; Myllykangas L; Oinas M; Revesz T; Lees A; Boeve BF; Petersen RC; Ferman TJ; Escott-Price V; Graff-Radford N; Cairns NJ; Morris JC; Stone DJ; Pickering-Brown S; Mann D; Dickson DW; Halliday GM; Singleton A; Guerreiro R; Bras J, 2017, 'Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies', Neurobiology of Aging, vol. 49, pp. 214.e13 - 214.e15, http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023

Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836

Tan RH; Kril JJ; Fatima M; McGeachie A; McCann H; Shepherd C; Forrest SL; Affleck A; Kwok JBJ; Hodges JR; Kiernan MC; Halliday GM, 2015, 'TDP-43 proteinopathies: Pathological identification of brain regions differentiating clinical phenotypes', Brain, vol. 138, pp. 3110 - 3122, http://dx.doi.org/10.1093/brain/awv220

Yang Y; Shepherd C; Halliday G, 2015, 'Aneuploidy in Lewy body diseases', Neurobiology of Aging, vol. 36, pp. 1253 - 1260, http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.016

Couttas TA; Kain N; Daniels B; Lim XY; Shepherd C; Kril J; Pickford R; Li H; Garner B; Don AS, 2014, 'Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer's disease pathogenesis', Acta Neuropathologica Communications, vol. 2, http://dx.doi.org/10.1186/2051-5960-2-9

Tan RH; Shepherd CE; Kril JJ; McCann H; McGeachie A; McGinley C; Affleck A; Halliday GM, 2014, 'Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43', Acta Neuropathologica Communications, vol. 2, pp. 33, http://dx.doi.org/10.1186/2051-5960-1-33

Rahman T; Davies DS; Tannenberg RK; Fok S; Shepherd C; Dodd PR; Cullen KM; Goldsbury C, 2014, 'Cofilin rods and aggregates concur with tau pathology and the development of alzheimer's disease', Journal of Alzheimer's Disease, vol. 42, pp. 1443 - 1460, http://dx.doi.org/10.3233/JAD-140393

Bhatia S; Jenner AM; Li H; Ruberu K; Spiro AS; Shepherd CE; Kril JJ; Kain N; Don A; Garner B, 2013, 'Increased apolipoprotein D dimer formation in alzheimer's disease hippocampus is associated with lipid conjugated diene levels', Journal of Alzheimer's Disease, vol. 35, pp. 475 - 486, http://dx.doi.org/10.3233/JAD-122278

Lim YA; Giese M; Shepherd CE; Halliday GM; Kobayashi M; Takamatsu K; Staufenbiel M; Eckert A; Gotz J, 2012, 'Role of hippocalcin in mediating Abeta toxicity', Biochimica et Biophysica ACTA - Molecular Basis of Disease, vol. 1822, pp. 1247 - 1257, http://dx.doi.org/10.1016/j.bbadis.2012.04.007

Dobson-Stone C; Hallupp M; Bartley L; Shepherd CE; Halliday GM; Schofield PR; Hodges JR; Kwok J, 2012, 'C9ORF72 repeat expansion in clinical and neuropathological frontotemporal dementia cohorts', Neurology, vol. 79, pp. 995 - 1001, http://dx.doi.org/10.1212/WNL.0b013e3182684634

Kerr ML; Gasperini R; Gibbs ME; Hou X; Shepherd CE; Strickland DK; Foa L; Lawen A; Small D, 2010, 'Inhibition of AB aggregation and neurotoxicity by the 39-kDa receptor-associated protein', Journal of Neurochemistry, vol. 112, pp. 1199 - 1209, http://dx.doi.org/10.1111/j.1471-4159.2009.06540.x

Mitew S; Kirkcaldie MTK; Halliday GM; Shepherd CE; Vickers JC; Dickson TC, 2010, 'Focal demyelination in Alzheimer's disease and transgenic', ACTA Neuropathologica, vol. 119, pp. 567 - 577, http://dx.doi.org/10.1007/s00401-010-0657-2

Shepherd CE; Mccann H; Halliday GM, 2009, 'Variations in the neuropathology of familial Alzheimer's disease', ACTA Neuropathologica, vol. 118, pp. 37 - 52, http://dx.doi.org/10.1007/s00401-009-0521-4

Woodhouse A; Shepherd CE; Sokolova A; Carroll V; King AE; Halliday GM; Dickson TC; Vickers J, 2009, 'Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease', ACTA Neuropathologica, vol. 117, pp. 19 - 29, http://dx.doi.org/10.1007/s00401-008-0458-z

Sokolova A; Hill MD; Rahimi F; Warden LA; Halliday GM; Shepherd CE, 2009, 'Monocytle chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease', Brain Pathology, vol. 19, pp. 392 - 398, http://dx.doi.org/10.1111/j.1750-3639.2008.00188.x

Shepherd CE; Gregory G; Warden L; Halliday G, 2009, 'O2-03-02: Oligomeric Aβ40 species accumulate in the toxic plaques in Alzheimer's disease', Alzheimer's & Dementia, vol. 5, pp. P107 - P107, http://dx.doi.org/10.1016/j.jalz.2009.05.335

Shepherd CE; Grace E; Mann DM; Halliday GM, 2007, 'Relationship between neuronal loss and 'inflammatory plaques' in early onset Alzheimer's disease', Neuropathology and Applied Neurobiology, vol. 33, pp. 328 - 333, http://dx.doi.org/10.1111/j.1365-2990.2006.00816.x

Shepherd CE; Goyette JD; Utter V; Rahimi F; Yang Z; Geczy C; Halliday GM, 2006, 'Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease', Neurobiology of Aging, vol. 27, pp. 1554 - 1563, http://dx.doi.org/10.1016/j.neurobiolaging.2005.09.033

Rahimi F; Shepherd CE; Halliday GM; Geczy C; Raftery MJ, 2006, 'Antigen-epitope retrieval to facilitate proteomic analysis of formalin-fixed archival brain tissue', Analytical Chemistry, vol. 78, pp. 7216 - 7221, http://dx.doi.org/10.1021/ac060294s

David DJ; Ittner L; Gehrig P; Nergenau D; Shepherd CE; Halliday GM; Gotz J, 2006, 'Beta-amyloid treatment of two complementary P301L tau-expressing Alzheimer's disease models reveals similar deregulated cellular processes', Proteomics, vol. 6, pp. 6566 - 6577, http://dx.doi.org/10.1002/pmic.200600634

Götz J; David D; Ittner L; Halliday G; Shepherd C, 2006, 'S5-03-01: Animal and cellular models - tau-Abeta interaction', Alzheimer's & Dementia, vol. 2, pp. S92 - S92, http://dx.doi.org/10.1016/j.jalz.2006.05.362

Halliday GM; Song YC; Lepar GS; Brooks WS; Kwok JB; Kersaitis C; Gregory GC; Shepherd CE; Rahimi F; Schofield PR; Kril J, 2005, 'Pick bodies in a family with presenilin-1 Alzheimer's disease', Annals of Neurology, vol. 57, pp. 139 - 143, http://dx.doi.org/10.1002/ana.20366

Halliday GM; Ophof A; Broe M; Jensen PH; Kettle E; Fedorow HS; Cartwright M; Griffiths F; Shepherd CE; Double KL, 2005, 'alpha-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson`s disease', Brain, vol. 128, pp. 2654 - 2664, http://dx.doi.org/10.1093/brain/awh584

Broe M; Shepherd CE; Mann DM; Milward EA; Gai WP; Kettle E; Halliday GM, 2005, 'Insoluble alpha-synuclein in Alzheimer's disease without Lewy body formation', Neurotoxicity Research, vol. 7, pp. 69 - 76, http://dx.doi.org/10.1007/BF03033777

Shepherd CE; Gregory GC; Vickers J; Halliday GM, 2005, 'Novel 'inflammatory plaque' pathology in presenelin-1 Alzheimer's disease', Neuropathology and Applied Neurobiology, vol. 31, pp. 503 - 511, http://dx.doi.org/10.1111/j.1365-2990.2005.00667.x

Shepherd CE; Gregory GC; Vickers J; Brooks WS; Kwok J; Schofield PR; Kril J; Halliday GM, 2004, 'Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques', Neurobiology of Disease, vol. 15, pp. 115 - 119, http://dx.doi.org/10.1016/j.nbd.2003.10.008

Shepherd CE; Piguet O; Broe G; Creasey H; Waite LM; Brooks WS; Kril J, 2004, 'Histocompatibility antigens, aspirin use and cognitive performance in non-demented elderly subjects', Journal of Neuroimmunology, vol. 148, pp. 178 - 182, http://dx.doi.org/10.1016/j.jneuroim.2003.11.007

Broe M; Hodges JR; Schofield E; Shepherd CE; Kril J; Halliday GM, 2003, 'Staging disease severity in pathologically confirmed cases of frontotemporal dementia', Neurology, vol. 60, pp. 1005 - 1011, http://dx.doi.org/10.1212/01.WNL.0000052685.09194.39

Stanford PM; Shepherd CE; Halliday GM; Brooks WS; Schofield PR, 2003, 'Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia', Brain, vol. 126, pp. 814 - 826, http://dx.doi.org/10.1093/brain/awg090

Schofield E; Kersaitis C; Shepherd CE; Kril J; Halliday GM, 2003, 'Severity of gliosis in Pick`s disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders', Brain, vol. 126, pp. 827 - 840, http://dx.doi.org/10.1093/brain/awg085

Munch G; Shepherd CE; Mccann H; Brooks WS; Kwok JB; Arendt T; Hallupp M; Schofield PR; Martins RN; Halliday GM, 2002, 'Intraneuronal advanced glycation endproducts in presenilin-l Alzheimer's disease', Neuroreport, vol. 13, pp. 601 - 604

Shepherd CE; Mccann H; Kettle E; Halliday GM, 2002, 'Neurofilament-immunoreactive neurons in Alzheimer's disease and dementia with Lewy Bodies', Neurobiology of Disease, vol. 9, pp. 249 - 257, http://dx.doi.org/10.1006/nbdi.2001.0469

Mackenzie IRA; Halliday G; Shepherd C, 2001, 'Cortical inflammation in dementia with Lewy bodies [3] (multiple letters)', Archives of Neurology, vol. 58, pp. 519 - 520, http://dx.doi.org/10.1001/archneur.58.3.519

Shepherd CE; Kettle E; Mccann H; Halliday GM, 2001, 'Neurofilament-immunoreactive neurons are not selectively vulnerable in Alzheimer's disease.', Neurobiology of Disease, vol. 8, pp. 136 - 146, http://dx.doi.org/10.1006/nbdi.2000.0361

Broe M; Shepherd CE; Halliday GM; Milward EA, 2001, 'Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies.', ACTA Neuropathologica, vol. 101, pp. 616 - 624

Halliday GM; Shepherd CE, 2001, 'Cortical inflammation in dementia with Lewy bodies.', Archives of Neurology, vol. 58, pp. 519 - 520, http://dx.doi.org/10.1001/archneur.58.3.519

Shepherd CE; Bowes S; Parkinson D; Cambray-Deakin M; Pearson RCA, 2000, 'Expression of amyloid precursor protein in human astrocytes in vitro: Isoform-specific increases following heat shock', NEUROSCIENCE, vol. 99, pp. 317 - 325, http://dx.doi.org/10.1016/S0306-4522(00)00197-4

Halliday GM; Shepherd CE; Mccann H; Reid WG; Grayson DA; Broe T; Kril J, 2000, 'Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease', Archives of Neurology, vol. 57, pp. 831 - 836, http://dx.doi.org/10.1001/archneur.57.6.831

Shepherd CE; Kettle E; Mccann H; Harding AJ; Halliday GM, 2000, 'Cortical inflammation in Alzheimer's disease but not dementia with Lewy bodies', Archives of Neurology, vol. 57, pp. 817 - 822, http://dx.doi.org/10.1001/archneur.57.6.817

Halliday GM; Robinson S; Shepherd CE; Kril J, 2000, 'Alzheimer's disease and imflammation: a review of cellular and therapeutic mechanisms', Clinical and Experimental Pharmacology and Physiology, vol. 27, pp. 1 - 8, http://dx.doi.org/10.1046/j.1440-1681.2000.03200.x

Amadoru S; Doré V; McLean CA; Hinton F; Shepherd CE; Halliday GM; Leyton CE; Yates PA; Hodges JR; Masters CL; Villemagne VL; Rowe CC, 'Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s Disease', , http://dx.doi.org/10.21203/rs.2.17082/v2

Conference Papers

Shepherd CE; Warden LA; Guillemin GJ, 2009, 'Inflammatory effects of Abeta alloforms and conformations on human astrocytes', in Khachaturian Z (ed.), Alzheimer's and Dementia, Elsevier, Orlando, Florida, pp. P482 - P482, presented at *, Vienna, Austria, 11 July 2009 - 16 July 2009

Halliday GM; Warden LA; Gregory GC; Kwok JB; Schofield PR; Guillemin GJ; Shepherd CE, 2009, 'Mass buildup of soluble oligomeric Abeta40 occurs in sporadic Alzheimer's disease', in Khachaturian Z (ed.), Alzheimer's and Dementia, Elsevier, Orlando, Florida, pp. P302 - P302, presented at *, Vienna, Austria, 11 July 2009 - 16 July 2009

Warden LA; Halliday GM; Guillemin GJ; Shepherd CE, 2009, 'Comparable neurotoxicity of oligomeric AB40 and AB 42 in a human in vitro model', in Neurodegenerative Diseases, Karger, Basel, pp. 381 - 381, presented at 9th International Conference AD/PD, Prague, 11 March 2009 - 15 March 2009

Woodhouse A; Carroll V; Sokolova A; Shepherd CE; Halliday GM; Dickson TC; Vickers J, 2008, 'Preseninil-1 familial Alzheimer's disease cases exhibit altered pathology in comparison to sporadic AD', in Proceedings of Aust Neuroscience Society, Australian Neuroscience Society 28th Annual Meeting, Hobart, pp. 113 - 113, presented at Australian Neuroscience Society 28th Annual Meeting, Hobart, 27 January 2008 - 30 January 2008

Warden LA; Guillemin GJ; Halliday GM; Shepherd CE, 2008, 'neuronal viability and tau pathology is not affected in huamn primary neurons co-cultured with astrocytes following stimulation with soluble abeta oligomers', in Proceedings of Aust Neuroscience Society, Australian Neuroscience Society 28th Annual Meeting, Hobart, pp. 113 - 113, presented at Australian Neuroscience Society 28th Annual Meeting, Hobart, 27 January 2008 - 30 January 2008

Gotz J; David DJ; Ittner L; Halliday GM; Shepherd CE, 2006, 'Animal and cellular models - Tau-Abeta interaction', in Khachaturian Z (ed.), Alzheimer's and Dementia, Elsevier, Orlando, Florida, pp. S92 - S92, presented at Alzheimer`s Association 10th International Conference of Alzheimer`s Disease and Related Disorders, Madrid, Spain, 15 July 2006 - 20 July 2006

Shepherd CE; Gregory GC; Warden LA; Halliday GM, 2006, 'Oligomeric AB40 species accumulate in the toxic plaques in Alzheimer's disease', in Khachaturian Z (ed.), Alzheimer's and Dementia, Elsevier, Orlando, Florida, pp. 107 - 107, presented at Alzheimer's Association 10th International Conference of Alzheimer's Disease and Related Disorders, Madrid, Spain, 15 July 2006 - 20 July 2006

Shepherd CE; Grace E; Mann DM; Halliday GM, 2006, 'Novel inflammatory plaques are not associated with greater neuronal cell loss', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 151 - 151, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006

Rahimi F; Raftery MJ; Halliday GM; Geczy C; Shepherd CE, 2006, 'Proteomic analysis of formalin-fixed brain tissue is potentially applicable to laser-microdissected specimens', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 41 - 41, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006

Rahimi F; Goyette J; Raftery MJ; Shepherd CE; Halliday GM; Geczy C, 2005, 'S100A9, an inflammation-associated calcium-binding protein, is a binding partner for various redox-regulating proteins in familial Alzheimer's disease', in Journal of the Neurological Sciences, Elsevier Science BV, Amsterdam, Netherlands, pp. S298 - S298, presented at XVIIIth World Congress of Neurology, Sydney, 05 November 2005 - 11 November 2005

Shepherd CE; Goyette J; Utter V; Rahimi F; Yang Z; Geczy C; Halliday GM, 2005, 'Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease', in Proceedings of Aust Neuroscience Society, 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, pp. 131 - 131, presented at 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, 30 January 2005 - 02 February 2005

Goyette J; Shepherd CE; Halliday GM; Geczy C, 2004, 'S100 proteins in Alzheimer's disease', in Australian Health and Medical Research Congress, Australian Health and Medical Research Congress 2004, Sydney, Convention & Exhibition Centre, pp. 206 - 206, presented at Australian Health and Medical Research Congress 2004, Sydney, Convention & Exhibition Centre, 21 November 2004 - 26 November 2004

Gregory GC; Kwok JB; Shepherd CE; Schofield PR; Halliday GM, 2004, 'Tau deposition in familial Alzheimer`s disease', in Australian Health and Medical Research Congress, Australian Health and Medical Research Congress 2004, Sydney, Convention & Exhibition Centre, pp. 227 - 227, presented at Australian Health and Medical Research Congress 2004, Sydney, Convention & Exhibition Centre, 21 November 2004 - 26 November 2004

Shepherd CE; Schofield E; Gregory GC; Halliday GM, 2004, 'Non-hyperphosphorylated tau accumulates in the pathological hallmarks in presenilin-1 Alzheimer's disease and frontotemporal dementia', in Neurobiology of Aging, Elsevier Science Inc, New York, NY, USA, pp. S428 - S429, presented at 9th International Conference on Alzheimer`s Disease and Related Disorders, Philadelphia, Pennsylvania, 17 July 2004 - 22 July 2004, http://dx.doi.org/10.1016/S0197-4580(04)81410-6

Gregory GC; Kwok JB; Shepherd CE; Brooks WS; Xuereb J; Schofield PR; Halliday GM, 2004, 'Beta-amyloid toxicity in Alzheimer's disease', in Proceedings of Aust Neuroscience Society, 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, pp. 42 - 42, presented at 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, 27 January 2004 - 30 January 2004

Shepherd CE; Gregory GC; Vickers J; Halliday GM, 2004, 'Novel inflammatory pathology in presenilin 1 Alzheimer's disease', in Proceedings of Aust Neuroscience Society, 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, pp. 153 - 153, presented at 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, 27 January 2004 - 30 January 2004

Shepherd CE; Schofield E; Gregory GC; Halliday GM; Kersaitis C; Kril J, 2003, 'Inflammation and neurodegeneration', in Journal of Clinical Neuroscience, Churchill Livingstone, Edinburgh, Midlothian, Scotland, pp. 780 - 781, presented at Australian Association of Neurologists Annual Scientific Meeting 2003, Darling Harbour, Sydney, 13 May 2003 - 16 May 2003

Broe M; Jensen PH; Shepherd CE; Halliday GM, 2003, 'Selective dopamine cell loss in Parkinson`s disease correlates with increased cellular alpha-synuclein', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 901 - 0901, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003

Shepherd CE; Stanford PM; Brooks WS; Kwok JB; Schofield PR; Brodaty H; Martins RN; Halliday GM, 2003, 'Absence of tau pathology in a familial frontotemporal dementia case with a mutation in the tau gene', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 375 - 375, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003

Gregory GC; Shepherd CE; Kwok JB; Schofield PR; Halliday GM, 2002, 'A beta pathology in presenilin-1 Alzheimer's disease', in Australian Health and Medical Research Congress, Australian Health and Medical Research Congress 2002, Melbourne Convention Centre, pp. 2648 - 2648, presented at Australian Health and Medical Research Congress 2002, Melbourne Convention Centre, 24 November 2002 - 29 November 2002

Shepherd C; Gregory G; McCann H; Halliday G; Kwok J; Schofield P; Kril J, 2002, 'Plaque pathology in presenilin-1 Alzheimer's disease', in NEUROBIOLOGY OF AGING, ELSEVIER SCIENCE INC, pp. S220 - S220, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000177465300812&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Broe M; Shepherd CE; Gai WP; Milward EA; Kettle E; Halliday GM, 2002, 'Alpha synuclein and Alzheimer's disease', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 130 - 130, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002

Schofield E; Kersaitis C; Shepherd CE; Kril J; Halliday GM, 2002, 'Tau positive microglia in trontotemporal dementia', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 148 - 148, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002

Kersaitis C; Schofield E; Shepherd CE; Kril J; Halliday GM, 2002, 'The staging of neuropathology in frontotemporal dementia', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 146 - 146, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002

Shepherd CE; Mccann H; Gregory GC; Kwok JB; Kril J; Halliday GM, 2002, 'Plaque pathology in presenelin-1 Alzheimer's disease', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 31 - 31, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002

Shepherd CE; Kril J; Halliday GM, 2001, 'Specificity of inflammatory pathology for Alzheimer's disease.', in Proceedings of Aust Neuroscience Society, 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, Qld, pp. 134 - 134, presented at 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, Qld, 28 January 2001 - 31 January 2001

Shepherd C; Kril J; Halliday G, 2000, 'Specificity of inflammatory pathology for Alzheimer's disease.', in BRAIN PATHOLOGY, INT SOC NEUROPATHOLOGY, pp. 709 - 709, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000088213000459&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

CHESSWILLIAMS R; SHEPHERD CE; COULDWELL CJ; REYNOLDS GP, 1995, 'THE ACTIONS OF CLOZAPINE, CHLORPROMAZINE AND THIORIDAZINE AT THE A(1)-ADRENOCEPTORS OF THE RAT VAS-DEFERENS AND SPLEEN', in BRITISH JOURNAL OF PHARMACOLOGY, STOCKTON PRESS, pp. P205 - P205, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995RZ54500205&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Posters

Rahimi F; Goyette JD; Shepherd CE; Halliday GM; Geczy C; Raftery M, 2005, 'S100A9, an inflammation-associated calcium-binding protein, is a binding partner for various redox-regulating proteins in familial Alzheimer's disease', in Journal of the Neurological Sciences, Elsevier Science BV, Sydney, AUSTRALIA, Vol. 238, pp. S298 - S298, presented at 18th World Congress of Neurology, Sydney, AUSTRALIA, 05 November 2005 - 11 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000235088002393&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Conference Presentations

Halliday GM; Shepherd CE; Mccann H, 2009, 'Genetic forms of Alzheimer's disease: What can they tell us?', in Genetic forms of Alzheimer's disease: What can they tell us?, 48th ASMR National Scientific Conference, Hobart, presented at 48th ASMR National Scientific Conference, Hobart, 15 November 2009 - 17 November 2009

Conference Abstracts

Poljak A; Braidy N; Maclean C; Shepherd C; Raftery MJ; Sachdev PS, 2017, 'Proteomics of the Alzheimer's disease brain: Neuropathology and neuroresilience [Poster Abstract P2-155]', in Alzheimer's and Dementia, Elsevier, London, UK, Vol. 13, pp. P667 - P667, presented at Alzheimer's Association International Conference (AAIC) 2017, London, UK, 16 July 2017 - 20 July 2017, http://dx.doi.org/10.1016/j.jalz.2017.06.806

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