Dr Bryce Vissel | Brain Sciences UNSW

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University role:

Adjunct Associate Professor

Bryce Vissel's work spans neurodegenerative diseases including Alzheimer’s, Parkinson’s and spinal disorders as well as studies of the neural basis of learning and memory and movement mechanisms.

After being awarded his PhD in medical genetics from the University of Melbourne in 1991, Professor Vissel joined Garvan’s Neuroscience Division, where he was subsequently awarded a National Health and Medical Research Council CJ Martin Fellowship to pursue neuroscience research with Professor Stephen Heinemann at the world-leading Salk Institute in San Diego, USA. He spent 10 years at Salk, where he authored a number of seminal studies describing molecular mechanisms that regulate synaptic function and their role in behaviour and neurological diseases. He also received several prestigious awards – a Human Frontiers Award, a Fulbright Award and a Lieberman Award.

In late 2002, Professor Vissel returned to Garvan taking up a position as Head of the Neurodegenerative Diseases group in the Neuroscience Division. His team’s work at the Garvan since then has, among other things, provided new insights into synapse function and shown that the brain has far greater potential for regeneration and repair than previously thought. Professor Vissel is also an important contributor to a number of organisations. He is Chair of the Advisory Board of Cellmid Ltd, a member of the Board of Parkinson’s NSW, and scientific advisor to Alzheimer’s Australia and SpinalCure Australia.

Keywords:

neuroscience

parkinson's disease

alzheimer's disease

regeneration

synaptic plasticity

Research

Research activities:

Neuroscience
Neurodegenerative diseases – Alzheimers Disease, Parkinson’s Disease
Regenerative medicine - spinal cord injury
Synaptic plasticity

Field of Research (FOR) Tag:

Central Nervous System

Socio-economic Objective (SEO) tags:

Neurodegenerative Disorders Related to Ageing

Publications related to this Person

Journal articles

Carter A; Richards LJ; Apthorp D; Azghadi MR; Badcock DR; Balleine B; Bekkers JM; Berk M; Bourne JA; Bradley AP; Breakspear M; Brichta A; Carter O; Castles A; Chakli K; Cohen-Woods S; Conn SJ; Cornish J; Cornish K; de Zubicaray G; Egan GF; Enticott PG; Fitzgibbon BM; Forlini C; Fornito A; Griffiths L; Gullifer J; Hall W; Halliday G; Hannan AJ; Harrer S; Harvey A; Hatherly C; Hickie IB; Kennett J; Kiernan M; Kilpatrick T; Kiral-Kornek I; Korgaonkar MS; Lawrence AJ; Leventer R; Levy N; Licinio J; Lovell N; Mackellar G; Malcolm L; Mason A; Mattingley JB; Medland SE; Michie PT; Nithianantharajah J; Parker J; Payne JM; Poole-Warren L; Sah P; Sarnyai Z; Schofield PR; Shimoni O; Shum DHK; Silk T; Slee M; Smith AE; Soulis T; Sriram S; Stuart GJ; Tapson J; Thompson MB; van Schaik A; Vincent NA; Vissel B; Waters A, 2020, 'Erratum: A Neuroethics Framework for the Australian Brain Initiative (Neuron (2019) 101(3) (365–369), (S0896627319300054), (10.1016/j.neuron.2019.01.004))', Neuron, vol. 105, pp. 201, http://dx.doi.org/10.1016/j.neuron.2019.12.019

Stayte S; Laloli KJ; Rentsch P; Lowth A; Li KM; Pickford R; Vissel B, 2020, 'The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain', Experimental Neurology, vol. 323, http://dx.doi.org/10.1016/j.expneurol.2019.113062

Zhong H; Zhu C; Minegishi Y; Richter F; Zdunowski S; Roy RR; Vissel B; Gad P; Gerasimenko Y; Chesselet MF; Edgerton VR, 2019, 'Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced Parkinsonism', Neurorehabilitation and Neural Repair, vol. 33, pp. 1029 - 1039, http://dx.doi.org/10.1177/1545968319876891

Clark IA; Vissel B, 2019, 'Neurodegenerative disease treatments by direct TNF reduction, SB623 cells, maraviroc and irisin and MCC950, from an inflammatory perspective–a Commentary', Expert Review of Neurotherapeutics, vol. 19, pp. 535 - 543, http://dx.doi.org/10.1080/14737175.2019.1618710

Rentsch P; Stayte S; Morris GP; Vissel B, 2019, 'Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on l-Dopa induced dyskinesia', BMC Neuroscience, vol. 20, http://dx.doi.org/10.1186/s12868-019-0487-7

Kennett J; Carter A; Bourne JA; Hall W; Levy N; Mattingley JB; Lawrence AJ; Forlini C; Malcolm L; Vincent N; Richards LJ; Egan GF; Breakspear M; Cornish K; Halliday G; Poole-Warren L; Sriram S; Soulis T; Fitzgibbon B; Kiral-Kornek I; Badcock DR; Balleine B; Bekkers JM; Berk M; Bradley A; Brichta A; Carter O; Castles A; Clements J; Cornish J; de Zubicaray G; Enticott PG; Fornito A; Griffiths L; Gullifer J; Hannan AJ; Harrer S; Harvey A; Hickie IB; Jazwinska L; Kiernan M; Kilpatrick T; Leventer R; Licinio J; Lovell N; Mackellar G; Medland SE; Michie PT; Nithianantharajah J; Parker J; Payne JM; Rossell S; Sah P; Sarnyai Z; Schofield PR; Shum DHK; Silk T; Slee M; Stuart GJ; Tapson J; van Schaik A; Vissel B; Waters A; Apthorp D; Cohen-Woods S; Conn SJ; Korgaonkar M; Mason A; Azghadi MR; Shimoni O; Smith A; Thompson MB, 2019, 'A Neuroethics Framework for the Australian Brain Initiative', Neuron, vol. 101, pp. 365 - 369, http://dx.doi.org/10.1016/j.neuron.2019.01.004

Chen H; Chan YL; Linnane C; Mao Y; Anwer AG; Sapkota A; Annissa TF; Herok G; Vissel B; Oliver BG; Saad S; Gorrie CA, 2018, 'L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-29430-6

Morris GP; Clark IA; Vissel B, 2018, 'Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer’s disease', Acta Neuropathologica, vol. 136, pp. 663 - 689, http://dx.doi.org/10.1007/s00401-018-1918-8

Clark IA; Vissel B, 2018, 'Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α-synuclein, amyloid-β and insulin resistance in neurodegenerative diseases', British Journal of Pharmacology, vol. 175, pp. 3859 - 3875, http://dx.doi.org/10.1111/bph.14471

Clark IA; Vissel B, 2018, 'The inflammatory nature of post-surgical delirium predicts benefit of agents with anti-TNF effects, such as dexmedetomidine', Frontiers in Neuroscience, vol. 12, http://dx.doi.org/10.3389/fnins.2018.00257

Mladenova D; Barry G; Konen LM; Pineda SS; Guennewig B; Avesson L; Zinn R; Schonrock N; Bitar M; Jonkhout N; Crumlish L; Kaczorowski DC; Gong A; Pinese M; Franco GR; Walkley CR; Vissel B; Mattick JS, 2018, 'Adar3 is involved in learning and memory in mice', Frontiers in Neuroscience, vol. 12, http://dx.doi.org/10.3389/fnins.2018.00243

Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, vol. 293, pp. 5731 - 5745, http://dx.doi.org/10.1074/jbc.RA117.000808

Chan YL; Saad S; Machaalani R; Oliver BG; Vissel B; Pollock C; Jones NM; Chen H, 2017, 'Maternal cigarette smoke exposure worsens neurological outcomes in adolescent offspring with hypoxic-ischemic injury', Frontiers in Molecular Neuroscience, vol. 10, http://dx.doi.org/10.3389/fnmol.2017.00306

Clark IA; Vissel B, 2017, 'The meteorology of cytokine storms, and the clinical usefulness of this knowledge', Seminars in Immunopathology, vol. 39, pp. 505 - 516, http://dx.doi.org/10.1007/s00281-017-0628-y

Stayte S; Vissel B, 2017, 'New hope for devastating neurodegenerative disease', Brain, vol. 140, pp. 1177 - 1179, http://dx.doi.org/10.1093/brain/awx064

Leake J; Zinn R; Corbit L; Vissel B, 2017, 'Dissociation between complete hippocampal context memory formation and context fear acquisition', Learning and Memory, vol. 24, pp. 153 - 157, http://dx.doi.org/10.1101/lm.044578.116

Stayte S; Rentsch P; Tröscher AR; Bamberger M; Li KM; Vissel B, 2017, 'Activin A inhibits MPTP and LPS-induced increases in inflammatory cell populations and loss of dopamine neurons in the mouse midbrain in Vivo', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0167211

Clark IA; Vissel B, 2016, 'Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents', Journal of Neuroinflammation, vol. 13, http://dx.doi.org/10.1186/s12974-016-0708-2

Wright AL; Vissel B, 2016, 'CAST your vote: Is calpain inhibition the answer to ALS?', Journal of Neurochemistry, vol. 137, pp. 140 - 141, http://dx.doi.org/10.1111/jnc.13296

Morris GP; Wright AL; Tan RP; Gladbach A; Ittner LM; Vissel B, 2016, 'A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0148503

Clark IA; Vissel B, 2015, 'Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease', British Journal of Pharmacology, vol. 172, pp. 3714 - 3727, http://dx.doi.org/10.1111/bph.13181

Stayte S; Rentsch P; Li KM; Vissel B, 2015, 'Activin a protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0124325

Clark IA; Vissel B, 2015, 'Amyloid β: One of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease', British Journal of Pharmacology, http://dx.doi.org/10.1111/bph.13181

Clark IA; Vissel B, 2015, 'A Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease', Neural Plasticity, vol. 2015, http://dx.doi.org/10.1155/2015/358263

Clark IA; Vissel B, 2014, 'Inflammation-sleep interface in brain disease: TNF, insulin, orexin', Journal of Neuroinflammation, vol. 11, http://dx.doi.org/10.1186/1742-2094-11-51

Morris GP; Clark IA; Vissel B, 2014, 'Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease', Acta Neuropathologica Communications, vol. 2, http://dx.doi.org/10.1186/s40478-014-0135-5

Stayte S; Vissel B, 2014, 'Advances in non-dopaminergic treatments for Parkinson's disease', Frontiers in Neuroscience, http://dx.doi.org/10.3389/fnins.2014.00113

Stayte S; Vissel B, 2014, 'Corrigendum: Advances in non-dopaminergic pharmacological treatments of Parkinson's disease', Frontiers in Neuroscience

Morris GP; Clark IA; Zinn R; Vissel B, 2013, 'Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research', Neurobiology of Learning and Memory, vol. 105, pp. 40 - 53, http://dx.doi.org/10.1016/j.nlm.2013.07.002

Wright AL; Zinn R; Hohensinn B; Konen LM; Beynon SB; Tan RP; Clark IA; Abdipranoto A; Vissel B, 2013, 'Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer's Disease', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0059586

Clark IA; Vissel B, 2013, 'Treatment implications of the altered cytokine-insulin axis in neurodegenerative disease', Biochemical Pharmacology, vol. 86, pp. 862 - 871, http://dx.doi.org/10.1016/j.bcp.2013.07.030

Clark I; Atwood C; Bowen R; Paz-Filho G; Vissel B, 2012, 'Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales', Pharmacological Reviews, vol. 64, pp. 1004 - 1026, http://dx.doi.org/10.1124/pr.112.005850

Wright A; Vissel B, 2012, 'The essential role of AMPA receptor GluA2 subunit RNA editing in the normal and diseased brain', Frontiers in Molecular Neuroscience, vol. 5, pp. 34, http://dx.doi.org/10.3389/fnmol.2012.00034

Gotz J; Schonrock N; Vissel B; Ittner L, 2011, 'Alzheimer's disease selective vulnerability and modelling in transgenic mice', Advances in Alzheimer's Disease, vol. 1, pp. 49 - 58, http://dx.doi.org/10.3233/978-1-60750-733-8-49

Clark I; Alleva L; Vissel B, 2011, 'TNF and leptin tell essentially the same story in Alzheimer's disease', Journal of Alzheimer's Disease, vol. 26, pp. 201 - 205, http://dx.doi.org/10.3233/JAD-2011-110266

McRoberts JA; Ennes HS; Marvizon JCG; Fanselow M; Mayer EA; Vissel B, 2011, 'Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test', Neuroscience, vol. 172, pp. 474 - 482, http://dx.doi.org/10.1016/j.neuroscience.2010.10.045

Clark I; Alleva L; Vissel B, 2010, 'The roles of TNF in brain dysfunction and disease', Pharmacology and Therapeutics, vol. 128, pp. 519 - 548, http://dx.doi.org/10.1016/j.pharmthera.2010.08.007

Wiltgen B; Royle G; Gray E; Abdipranoto A; Thangthaeng N; Jacobs N; Saab F; Tonegawa S; Heinemann SF; O''Dell T; Fanselow M; Vissel B, 2010, 'A role for calcium-permeable AMPA receptors in synaptic plasticity and learning', PLoS One, vol. 5, pp. 1 - 18, http://dx.doi.org/10.1371/journal.pone.0012818

Galbraith SA; Daniel JA; Vissel B, 2010, 'A study of clustered data and approaches to its analysis', Journal of Neuroscience, vol. 30, pp. 10601 - 10608, http://dx.doi.org/10.1523/JNEUROSCI.0362-10.2010

Daniel JA; Galbraith SA; Iacovitti L; Abdipranoto ; Vissel B, 2009, 'Functional heterogeneity at dopamine release sites', Journal of Neuroscience, vol. 29, pp. 14670 - 14680, http://dx.doi.org/10.1523/JNEUROSCI.1349-09.2009

Goetz J; Schonrock N; Vissel B; Ittner L, 2009, 'Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice', Journal of Alzheimer's Disease, vol. 18, pp. 243 - 251, http://dx.doi.org/10.3233/JAD-2009-1143

Abdipranoto-Cowley A; Jin SP; Croucher DR; Daniel JA; Henshall SM; Galbraith SA; Mervin K; Vissel B, 2009, 'Activin A is essential for neurogenesis following neurodegeneration', Stem Cells, vol. 27, pp. 1330 - 1346, http://dx.doi.org/10.1002/stem.80

Abdipranoto A; Wu S; Stayte S; Vissel B, 2008, 'The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development', CNS and Neurological Disorders - Drug Targets, vol. 7, pp. 187 - 210, http://dx.doi.org/10.2174/187152708784083858

Youn D; Royle G; Kolaj M; Vissel B; Randic M, 2008, 'Enhanced LTP of primary afferent neurotransmission in AMPA receptor GluR2-deficient mice', Pain, vol. 136, pp. 158 - 167, http://dx.doi.org/10.1016/j.pain.2007.07.001

Hinshelwood R; Huschtscha L; Melki J; Stirzaker C; Abdipranoto A; Vissel B; Ravasi T; Wells C; Hume DP; Reddel R; Clark SJ, 2007, 'Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis', Cancer research, vol. 67, pp. 11517 - 11527, http://dx.doi.org/10.1158/0008-5472.CAN-07-1284

Gray E; Fink A; Sarinana J; Vissel B; O Dell T, 2007, 'Long-term potentiation in the hippocampal CA1 region does not require insertion and activation of GluR2-lacking AMPA receptors', Journal of Neurophysiology, vol. 98, pp. 2488 - 2492, http://dx.doi.org/10.1152/jn.00473.2007

Skvorak K; Vissel B; Homanics GE, 2006, 'Production of conditional point mutant knockin mice', Genesis, vol. 44, pp. 345 - 353, http://dx.doi.org/10.1002/dvg.20222

Thomas CG; Krupp JJ; Bagley EE; Bauzon R; Heinemann SF; Vissel B; Westbrook GL, 2006, 'Probing N-Methyl-D-aspartate receptor desensitization with the substituted-cysteine accesibility method', Molecular Pharmacology, vol. 69, pp. 1296 - 1303, http://dx.doi.org/10.1124/mol.105.017350

Sonner JM; Vissel B; Royle G; Maurer A; Gong D; Baron NV; Harrison N; Fanselow M; Eger EI, 2005, 'The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene', Anesthesia and Analgesia, vol. 101, pp. 143 - 148, http://dx.doi.org/10.1213/01.ANE.0000152615.53435.B4

Hauser K; Aldrich J; Anderson KL; Bakalkin G; Hall E; Knapp P; Scheff S; Vissel B; Woods A; Yakovleva T; Shippenberg T; Christie MJ; Singh-Grewal I, 2005, 'Pathobiology of dynorphins in trauma and disease', Frontiers in Bioscience, vol. 10, pp. 216 - 235, http://dx.doi.org/10.2741/1522

Sonner JM; Antognini JF; Dutton RC; Flood P; Gray AT; Harris RA; Homanics GE; Kendig J; Orser B; Raines DE; Rampil IJ; Trudell J; Vissel B; Eger EI, 2004, 'Erratum: Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration (Anesthesia and Analgesia (September 2003) 97 (718-740))', Anesthesia and Analgesia, vol. 98, pp. 29

Petralia R; Sans N; Wang YX; Vissel B; Chang KJ; Noben-Trauth K; Heinemann S; Wenthold R, 2004, 'Loss of GLUR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acidreceptor subunit differentially affects remaining synaptic glutamatereceptors in cerebellum and cochlear nuclei', European Journal of Neuroscience, vol. 19, pp. 2017 - 2029, http://dx.doi.org/10.1111/j.0953-816X.2004.03324.x

Sans N; Vissel B; Petralia RS; Wang YX; Chang K; Royle GA; Wang CY; O'Gorman S; Heinemann SF; Wenthold RJ, 2003, 'Aberrant Formation of Glutamate Receptor Complexes in Hippocampal Neurons of Mice Lacking the GluR2 AMPA Receptor Subunit', Journal of Neuroscience, vol. 23, pp. 9367 - 9373, http://dx.doi.org/10.1523/jneurosci.23-28-09367.2003

Conference Papers

Morris G; Wright A; Stayte S; Zinn R; Tan R; Vissel B, 2017, 'Attaining reliable data in pre-clinical mouse models of middle cerebral artery occlusion: a case study with brain-derived and glial-derived neurotrophic factors', in INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, pp. 38 - 39, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000408221100104&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Reports

Richards LR; Michie PT; Badcock DR; Bartlett PF; Bekkers JM; Bourne JA; Castles A; Egan GF; Fornito A; Hannan AJ; Hickie IB; Mattingley JB; Schofield PR; Shum DHK; Stuart GJ; Vickers JC; Vissel B, 2016, Australian Brain Alliance, http://dx.doi.org/10.1016/j.neuron.2016.10.038

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