Associate Professor Vladimir Sytnyk

Tabs

Main

University role:

Associate Professor

Phone:

(+61 2) 9385 1108

Email:

v.sytnyk@unsw.edu.au

Biography

Education

1996: Specialist degree, Dnepropetrovsk National University, Dnepropetrovsk, Ukraine.
2002: PhD degree in Biology, Bogomoletz Institute of Physiology of the National Academy of Science of Ukraine, Kiev, Ukraine.
2016: Graduate certificate in University Learning and Teaching, UNSW.

Professional Experience

2017 - current: Associate Professor, School of Biotechnology and Biomolecular Sciences, UNSW
2009 - 2017: Senior Lecturer, School of Biotechnology and Biomolecular Sciences, UNSW
2004 - 2009: Group Leader, Institute for Biosynthesis of Neuronal Structures, Centre for Molecular Neurobiology, Hamburg, Germany.
2002 - 2004: Postdoctoral Fellow, Institute for Biosynthesis of Neuronal Structures, Centre for Molecular Neurobiology, Hamburg, Germany.

Research

Research Interests and Contributions

In the brain, information is transmitted, processed and memorised by neurons. To perform these functions, neurons must grow and form networks, in which individual neurons are connected to other neurons by specialised contacts called synapses. Neurons use synapses to communicate with other neurons and to process and store information.

The formation and maintenance of the neuronal networks and synapses is regulated by neural cell adhesion molecules expressed at the cell surface of neurons (see our review Sytnyk et al., Trends in Neurosciences, 2017). Our laboratory is interested in understanding the molecular and cellular mechanisms of this regulation and effects of its loss in disease. We also develop new technologies aimed at improving brain performance, enhancing learning and maintaining memory by modulating neural cell adhesion molecules.

My early work showed that neural cell adhesion molecules are the first proteins accumulating at nascent synaptic contacts between developing neurons and that these proteins stabilize the contacts and induce their transformation into mature synapses by capturing synaptic precursor organelles (Sytnyk et al., Journal of Cell Biology, 2002, featured on the cover page). We then found that neural cell adhesion molecules regulate the key processes involved in neuronal growth and synapse formation including intracellular signalling (Leshchyns’ka et al., Journal of Cell Biology, 2003; Bodrikov et al., Journal of Cell Biology, 2005, 2008; Sheng et al., Journal of Neuroscience, 2015), the assembly of the cytoskeleton (Puchkov et al., Cerebral Cortex, 2011; Li et al., Journal of Neuroscience, 2013) and polarised intracellular transport (Chernyshova et al., Journal of Neuroscience, 2011). We demonstrated that neural cell adhesion molecules modulate the assembly and maturation of the neurotransmitter-releasing machinery in axons (Leshchyns’ka et al., Neuron, 2006; Shetty et al., Journal of Neuroscience, 2013) and neurotransmitter-detecting machinery in dendrites of neurons (Sytnyk et al., Journal of Cell Biology, 2006; Sheng et al., Cerebral Cortex, 2019).

By using a novel technique for analysis of synapses in brains of individuals affected by neurodegenerative disorders, we demonstrated that the loss of synapses in Alzheimer’s disease is linked to the degradation of synaptic neural adhesion molecules (Leshchyns’ka et al., 2015; featured at the Medical News website and others, the front page of the UNSW website and in the Newsletter (Summer 2015/16) of the Australia and New Zealand Society for Cell and Developmental Biology). Currently, we analyse mechanisms of this loss and develop strategies that can be used to prevent it. We also investigate changes in neural cell adhesion in other neurodegenerative disorders such as Parkinson’s disease and motor neuron disease and use new transgenic mice to model abnormal function of neural cell adhesion molecules in these disorders and study its effects on the brain.

Selected Publications

Sheng L, Leshchyns'ka I, Sytnyk V. (2019) Neural cell adhesion molecule 2 (NCAM2)-induced c-Src-dependent propagation of submembrane Ca²⁺ spikes along dendrites inhibits synapse maturation. Cerebral Cortex 29(4):1439-1459.

Sytnyk V, Leshchyns'ka I, Schachner M. (2017) Neural cell adhesion molecules of the immunoglobulin superfamily regulate synapse formation, maintenance, and function. Trends in Neurosciences. 40(5):295-308.

Leshchyns'ka I, Liew HT, Shepherd C, Halliday GM, Stevens CH, Ke YD, Ittner LM, Sytnyk V. (2015) Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease. Nature Communications. 6:8836. F1000Prime recommended.

Wobst H, Schmitz B, Schachner M, Diestel S, Leshchyns'ka I, Sytnyk V. (2015) Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface. J Cell Sci. 128(15):2816-29.

Sheng L, Leshchyns'ka I, Sytnyk V. (2015) Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. Journal of Neuroscience. 35(4):1739-52.

Shetty A, Sytnyk V, Leshchyns'ka I, Puchkov D, Haucke V, Schachner M. (2013) The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms. J Neurosci. 33(42):16828-45. F1000Prime recommended.

Li S, Leshchyns'ka I, Chernyshova Y, Schachner M, Sytnyk V. (2013) The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1). J Neurosci. 33(2):790-803.

Tian N, Leshchyns'ka I, Welch JH, Diakowski W, Yang H, Schachner M, Sytnyk V. (2012) Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis. J Biol Chem. 287(53):44447-63.

Chernyshova Y, Leshchyns'ka I, Hsu SC, Schachner M, Sytnyk V. (2011) The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. J Neurosci. 31(10):3522-35.

Leshchyns'ka I, Tanaka MM, Schachner M, Sytnyk V. (2011) Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions. J Biol Chem. 286(26):23397-406.

Puchkov D, Leshchyns'ka I, Nikonenko AG, Schachner M, Sytnyk V. (2011) NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation. Cerebral Cortex. 21(10):2217-32.

Leshchyns'ka I, Sytnyk V, Richter M, Andreyeva A, Puchkov D, Schachner M. (2006) The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles. Neuron. 52(6):1011-25. F1000Prime recommended.

Sytnyk V, Leshchyns'ka I, Nikonenko AG, Schachner M. (2006) NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex. J Cell Biol. 174(7):1071-85.

Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, Schachner M. (2002) Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts. J Cell Biol. 159(4):649-61. F1000Prime recommended.

Research

Field of Research (FOR) Tag:

Cell Neurochemistry

Biochemistry and Cell Biology

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

Cellular Nervous System

Neurobiology

Socio-economic Objective (SEO) tags:

Expanding Knowledge in the Biological Sciences

Neurodegenerative Disorders Related to Ageing

Nervous System and Disorders

Teaching & Supervision

I am available to supervise:

Yes

Publications related to this Person

Book Chapters

Schachner M; Leshchyns’ka I; Sytnyk V, 2016, 'Functions of the neural cell adhesion molecule (NCAM) at the synapse', in The Curated Reference Collection in Neuroscience and Biobehavioral Psychology, pp. 91 - 96, http://dx.doi.org/10.1016/B978-0-12-809324-5.02402-0

Journal articles

Keable R; Leshchyns’ka I; Sytnyk V, 2020, 'Trafficking and Activity of Glutamate and GABA Receptors: Regulation by Cell Adhesion Molecules', Neuroscientist, vol. 26, pp. 415 - 437, http://dx.doi.org/10.1177/1073858420921117

Sytnyk V; Fath T, 2020, 'Editorial: From Structure to Function - The Interplay Between Cell Adhesion Molecules and the Cytoskeleton', Frontiers in Cell and Developmental Biology, vol. 8, pp. 104, http://dx.doi.org/10.3389/fcell.2020.00104

Huang R; Yuan DJ; Li S; Liang XS; Gao Y; Lan XY; Qin HM; Ma YF; Xu GY; Schachner M; Sytnyk V; Boltze J; Ma QH; Li S, 2020, 'NCAM regulates temporal specification of neural progenitor cells via profilin2 during corticogenesis', Journal of Cell Biology, vol. 219, http://dx.doi.org/10.1083/jcb.201902164

Bliim N; Leshchyns'ka I; Keable R; Chen BJ; Curry-Hyde A; Gray L; Sytnyk V; Janitz M, 2019, 'Early transcriptome changes in response to chemical long-term potentiation induced via activation of synaptic NMDA receptors in mouse hippocampal neurons', Genomics, vol. 111, pp. 1676 - 1686, http://dx.doi.org/10.1016/j.ygeno.2018.11.019

Guseva D; Jakovcevski I; Irintchev A; Leshchyns’Ka I; Sytnyk V; Ponimaskin E; Schachner M, 2018, 'Cell adhesion molecule close homolog of L1 (CHL1) guides the regrowth of regenerating motor axons and regulates synaptic coverage of motor neurons', Frontiers in Molecular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fnmol.2018.00174

Sheng L; Leshchyns'ka I; Sytnyk V, 2018, 'Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.', Cereb Cortex, http://dx.doi.org/10.1093/cercor/bhy041

Tan RPA; Leshchyns’Ka I; Sytnyk V, 2017, 'Glycosylphosphatidylinositol-anchored immunoglobulin superfamily cell adhesion molecules and their role in neuronal development and synapse regulation', Frontiers in Molecular Neuroscience, vol. 10, http://dx.doi.org/10.3389/fnmol.2017.00378

Duncan T; Lowe A; Sidhu K; Sachdev P; Lewis T; Lin RCY; Sytnyk V; Valenzuela M, 2017, 'Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin.', Stem Cell Reports, vol. 9, pp. 557 - 570, http://dx.doi.org/10.1016/j.stemcr.2017.07.008

Sytnyk V; Leshchyns'ka I; Schachner M, 2017, 'Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function', Trends in Neurosciences, vol. 40, pp. 295 - 308, http://dx.doi.org/10.1016/j.tins.2017.03.003

Bliim N; Leshchyns’ka I; Sytnyk V; Janitz M, 2016, 'Transcriptional regulation of long-term potentiation', Neurogenetics, vol. 17, pp. 201 - 210, http://dx.doi.org/10.1007/s10048-016-0489-x

Cheng YY; Wright CM; Kirschner MB; Williams M; Sarun KH; Sytnyk V; Leshchynska I; Edelman JJ; Vallely MP; McCaughan BC; Klebe S; van Zandwijk N; Lin RCY; Reid G, 2016, 'KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma', Molecular Cancer, vol. 15, http://dx.doi.org/10.1186/s12943-016-0529-z

Leshchyns'ka I; Sytnyk V, 2016, 'Reciprocal interactions between cell adhesion molecules of the immunoglobulin superfamily and the cytoskeleton in neurons', Frontiers in Cell and Developmental Biology, vol. 4, pp. 9, http://dx.doi.org/10.3389/fcell.2016.00009

Leshchyns'Ka I; Sytnyk V, 2016, 'Synaptic Cell Adhesion Molecules in Alzheimer's Disease', Neural Plasticity, vol. 2016, http://dx.doi.org/10.1155/2016/6427537

Leshchyns'Ka I; Liew HT; Shepherd C; Halliday GM; Stevens CH; Ke YD; Ittner LM; Sytnyk V, 2015, 'Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease', Nature Communications, vol. 6, http://dx.doi.org/10.1038/ncomms9836

Schmalbach B; Lepsveridze E; Djogo N; Papashvili G; Kuang F; Leshchyns'Ka I; Sytnyk V; Nikonenko AG; Dityatev A; Jakovcevski I; Schachner M, 2015, 'Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene', Journal of Neurochemistry, vol. 135, pp. 830 - 844, http://dx.doi.org/10.1111/jnc.13284

Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of cell science, vol. 128, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.169391

Sytnyk V; Fath T, 2015, 'Synapse Function in Dementia and Neurodegenerative Disorders', Australian Biochemist, vol. 46, https://www.asbmb.org.au/magazine/2015_April_Issue46-1/Showcase%204%20-%20Fath.pdf

Sheng L; Leshchyns’Ka I; Sytnyk V, 2015, 'Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca²⁺ levels', Journal of Neuroscience, vol. 35, pp. 1739 - 1752, http://dx.doi.org/10.1523/JNEUROSCI.1714-14.2015

Wobst H; Schmitz B; Schachner M; Diestel S; Leshchyns'ka I; Sytnyk V, 2015, 'Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface', Journal of Cell Science, vol. 128, pp. 2816 - 2829, http://dx.doi.org/10.1242/jcs.169391

Leshchyns'ka I; Sytnyk V, 2015, 'Intracellular transport and cell surface delivery of the neural cell adhesion molecule (NCAM)', Bioarchitecture, vol. 5, pp. 54 - 60, http://dx.doi.org/10.1080/19490992.2015.1118194

Robinson JW; Leshchyns'ka I; Farghaian H; Hughes WE; Sytnyk V; Neely GG; Cole AR, 2014, 'PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes', Biochemical Journal, vol. 464, pp. 145 - 156, http://dx.doi.org/10.1042/BJ20140497

Sheng L; Leshchyns'Ka I; Sytnyk V, 2013, 'Cell adhesion and intracellular calcium signaling in neurons', Cell Communication and Signaling, vol. 11, http://dx.doi.org/10.1186/1478-811X-11-94

Shetty A; Sytnyk V; Leshchyns'ka I; Puchkov D; Haucke V; Schachner M, 2013, 'The neural cell adhesion molecule promotes maturation of the presynaptic endocytotic machinery by switching synaptic vesicle recycling from adaptor protein 3 (AP-3)- to AP-2-dependent mechanisms', Journal of Neuroscience, vol. 33, pp. 16828 - 16845, http://dx.doi.org/10.1523/JNEUROSCI.2192-13.2013

Li S; Leshchyns'ka I; Chernyshova Y; Schachner M; Sytnyk V, 2013, 'The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated Kinase 1 (Pak1)', Journal of Neuroscience, vol. 33, pp. 790 - 803, http://dx.doi.org/10.1523/JNEUROSCI.1238-12.2013

Leshchyns’ka I; Sytnyk V, 2013, 'Isolation of Growth Cones from Mouse Brain', BIO-PROTOCOL, vol. 3, http://dx.doi.org/10.21769/bioprotoc.853

Tian N; Leshchyns'ka I; Welch J; Diakowski W; Yang H; Schachner M; Sytnyk V, 2012, 'Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis.', The Journal of Biological Chemistry, vol. 287, pp. 44447 - 44463, http://dx.doi.org/10.1074/jbc.M112.394973

Yang H; Sytnyk V; Crossley M; Galea AM, 2012, 'Controlling the size of lipid droplets: Lipid and protein factors', Current Opinion in Cell Biology, vol. 24, pp. 509 - 516, http://dx.doi.org/10.1016/j.ceb.2012.05.012

Poplawski GHD; Transziska AK; Leshchyns'ka I; Meier ID; Streichert T; Sytnyk V; Schachner M, 2012, 'L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth', Molecular and Cellular Neuroscience, vol. 50, pp. 169 - 178, http://dx.doi.org/10.1016/j.mcn.2012.03.010

Chernyshova Y; Leshchyns'ka I; Hsu SC; Schachner M; Sytnyk V, 2011, 'The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones', Journal of Neuroscience, vol. 31, pp. 3522 - 3535, http://dx.doi.org/10.1523/JNEUROSCI.3109-10.2011

Leshchyns'ka I; Tanaka M; Schachner M; Sytnyk V, 2011, 'Immobilized pool of NCAM180 in the postsynaptic membrane is homeostatically replenished by the flux of NCAM180 from extrasynaptic regions', The Journal of Biological Chemistry, vol. 286, pp. 23397 - 23406, http://dx.doi.org/10.1074/jbc.M111.252098

Puchkov D; Leshchyns ka I; Nikonenko A; Schachner M; Sytnyk V, 2011, 'NCAM/Spectrin Complex Disassembly Results in PSD Perforation and Postsynaptic Endocytic Zone Formation.', Cerebral cortex, vol. 21, pp. 2217 - 2232, http://dx.doi.org/10.1093/cercor/bhq283

Chernyshova Y; Leshchyns'ka I; Hsu SC; Schachner M; Sytnyk V, 2011, 'The Neural Cell Adhesion Molecule Promotes FGFR-Dependent Phosphorylation and Membrane Targeting of the Exocyst Complex to Induce Exocytosis in Growth Cones', Journal of Neuroscience, vol. 31, pp. 3522 - 3535, http://dx.doi.org/10.1523/?JNEUROSCI.3109-10.2011

Devanathan V; Jakovcevski I; Santuccione A; Li S; Lee HJ; Peles E; Leshchyns ka I; Sytnyk V; Schachner M, 2010, 'Cellular form of prion protein inhibits Reelin-mediated shedding of Caspr from the neuronal cell surface to potentiate Caspr-mediated inhibition of neurite outgrowth.', Journal of Neuroscience, vol. 30, pp. 9292 - 9305, http://dx.doi.org/10.1523/JNEUROSCI.5657-09.2010

Andreyeva A; Leshchyns ka I; Knepper M; Betzel C; Redecke L; Sytnyk V; Schachner M, 2010, 'CHL1 Is a Selective Organizer of the Presynaptic Machinery Chaperoning the SNARE Complex', PLoS One, vol. 5, pp. e12018, http://dx.doi.org/10.1371/journal.pone.0012018

Westphal D; Sytnyk V; Schachner M; Leshchyns ka I, 2010, 'Clustering of the neural cell adhesion molecule (NCAM) at the neuronal cell surface induces caspase-8 and -3 dependent changes of the spectrin meshwork required for NCAM-mediated neurite outgrowth.', The Journal of Biological Chemistry, vol. 285, pp. 42046 - 42057, http://dx.doi.org/10.1074/jbc.M110.177147

Bodrikov V; Sytnyk V; Leshchyns ka I; den Hertog J; Schachner M, 2008, 'NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.', Journal of Cell Biology, vol. 182, pp. 1185 - 1200, http://dx.doi.org/10.1083/jcb.200803045

Jakovcevski I; Wu J; Karl N; Leshchyns ka I; Sytnyk V; Chen J; Irintchev A; Schachner M, 2007, 'Glial scar expression of CHL1, the close homolog of the adhesion molecule L1, limits recovery after spinal cord injury.', Journal of Neuroscience, vol. 27, pp. 7222 - 7233, http://dx.doi.org/10.1523/JNEUROSCI.0739-07.2007

Leshchyns ka I; Sytnyk V; Richter M; Andreyeva A; Puchkov D; Schachner M, 2006, 'The adhesion molecule close homologue of L1 (CHL1) regulates uncoating of clathrin-coated synaptic vesicles.', Neuron, vol. 52, pp. 1011 - 1025, http://dx.doi.org/10.1016/j.neuron.2006.10.020

Sytnyk V; Leshchyns ka I; Nikonenko I; Schachner M, 2006, 'NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex.', Journal of Cell Biology, vol. 174, pp. 1071 - 1085, http://dx.doi.org/10.1083/jcb.200604145

Ader RI; Sytnyk V; Dityatev A; Richard G; Schachner M; Bartsch U, 2005, 'Electroporation-based gene transfer for efficient transfection of neural precursor cells', Molecular Brain Research, vol. 138, pp. 182 - 190, http://dx.doi.org/10.1016/j.molbrainres.2005.04.010

Santuccione A; Sytnyk V; Leshchyns ka I; Schachner M, 2005, 'Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.', Journal of Cell Biology, vol. 169, pp. 341 - 354, http://dx.doi.org/10.1083/jcb.200409127

Bodrikov V; Leshchyns ka I; Sytnyk V; Overvoorde J; den Hertog J; Schachner M, 2005, 'RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation.', Journal of Cell Biology, vol. 168, pp. 127 - 139, http://dx.doi.org/10.1083/jcb.200405073

Sytnyk V; Leshchyns'ka I; Dityatev A; Schachner M, 2004, 'Trans-Golgi network delivery of synaptic proteins in synaptogenesis', Journal of Cell Science, vol. 117, pp. 381 - 388, http://dx.doi.org/10.1242/jcs.00956

Dityatev A; Dityateva G; Sytnyk V; Delling M; Toni N; Nikonenko I; Muller D; Schachner M, 2004, 'Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses.', Journal of Neuroscience, vol. 24, pp. 9372 - 9382, http://dx.doi.org/10.1523/JNEUROSCI.1702-04.2004

Leshchyns ka I; Sytnyk V; Morrow JS; Schachner M, 2002, 'Neural cell adhesion molecule (NCAM) association with PKCbeta2 via betaI spectrin is implicated in NCAM-mediated neurite outgrowth.', Journal of Cell Biology, vol. 161, pp. 625 - 639, http://dx.doi.org/10.1083/jcb.200303020

Sytnyk V; Leshchyns ka I; Delling M; Dityateva G; Dityatev A; Schachner M, 2002, 'Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts.', Journal of Cell Biology, vol. 161, pp. 625 - 639, http://dx.doi.org/10.1083/jcb.200205098

Delling M; Wischmeyer E; Dityatev A; Sytnyk V; Veh RW; Karschin A; Schachner M, 2002, 'The neural cell adhesion molecule regulates cell-surface delivery of Gprotein- activated inwardly rectifying potassium channels via lipid rafts.', Journal of Neuroscience, vol. 22, pp. 7154 - 7164

Niethammer P; Delling M; Sytnyk V; Dityatev A; Fukami K; Schachner M, 2002, 'Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis', Journal of Cell Biology, vol. 157, pp. 521 - 532, http://dx.doi.org/10.1083/jcb.200109059

Sytnyk VN; Korogod SM; Dityatev AE, 2001, 'Diffusion and active transport of NCAM within the neuronal plasma membrane', Neurophysiology, vol. 33, pp. 140 - 147, http://dx.doi.org/10.1023/A:1012813501355

Sytnyk VN; Dityatev AE; Korogod SM, 2001, 'Distribution of cell adhesion molecules (CAM) along the branching neurite surface: Model-inherited effects of the branch diameters and mode of CAM transport', Neurophysiology, vol. 33, pp. 11 - 14, http://dx.doi.org/10.1023/A:1010451928251

Sytnyk VN, 1999, 'Simulated distributions of the density of cell adhesion molecules over branching processes with different geometry and intracellular trafficking', Neurophysiology, vol. 31, pp. 239 - 244, http://dx.doi.org/10.1007/BF02515096

Sytnyk VN; Berezin VA; Korogod SM, 1998, 'Geometry-induced inhomogeneity of distribution of cell adhesion molecules along branching processes', Neurophysiology, vol. 30, pp. 155 - 162, http://dx.doi.org/10.1007/BF02463428

Conference Papers

Chemyshova Y; Leshchynska I; Hsu S-C; Schachner M; Sytnyk V, 2009, 'NCAM targets the exocyst complex to growth cone surface membranes to promote exocytosis of TGN-derived organelles', in EUROPEAN JOURNAL OF CELL BIOLOGY, ELSEVIER GMBH, URBAN & FISCHER VERLAG, GERMANY, Konstanz, pp. 12 - 12, presented at 32nd Annual Meeting of the German-Society-for-Cell-Biology, GERMANY, Konstanz, 24 March 2009 - 27 March 2009, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264865700012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Richard I; Ader M; Sytnyk V; Dityatev A; Richard G; Schachner M; Bartsch U, 2003, 'Efficient transfection of neural stem cells by electroporation', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, FLORIDA, FT LAUDERDALE, pp. U404 - U404, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, FLORIDA, FT LAUDERDALE, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000184606802263&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Preprints

Amanda Tan RP; Kozlova I; Su F; Sah S; Keable R; Hagan DW; Bustamante S; Du X; Osborne B; Turner N; Clemens KJ; Begg D; Phelps EA; Yang H; Leshchyns’ka I; Sytnyk V, 2022, Neuronal growth regulator 1 (NEGR1) promotes synaptic targeting of glutamic acid decarboxylase 65 (GAD65), http://dx.doi.org/10.1101/2022.02.08.479601

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