Associate Professor Stewart Head | Brain Sciences UNSW

Tabs

Main

University role:

Adjunct Professor

Phone:

+61 2 9385 2555

Email:

s.head@unsw.edu.au

Over the last 22 years Dr Head’s research has been in the general area of skeletal muscle physiology. In particular his interest has been in the area of the muscular dystrophies and studying the role of [Ca2+]i in the physiology and pathophysiology of skeletal muscle. Dr Head’s laboratory has also performed substantial work on dystrophic mdx mouse cerebellum dysfunction. Dystrophin, the protein missing in Duchenne Muscular Dystrophy, is also normally expressed in the brain. His group demonstrated that dystrophin functions to cluster GABAA receptors at the post synaptic density of Purkinje neurons and in its absence that amplitude of inhibitory GABA currents is reduced by 50%, additionally; there is a 50% blunting of the Long Term Depression response at the parallel fibre/Purkinje synapse.

THE GENE FOR SPEED:- Dr Head has been involved in research into the role of skeletal muscle Z line cytoskeletal protein alpha-actinin-3 since. The gene encoding this protein is colloquially termed the “gene for speed”. The understanding of the consequences for skeletal muscle function of an absence of α-actinin-3, both in athletes and the general population, is of global importance given the mutation is present in more than 1 billion people worldwide. To date Dr Head has analysed the basic contractile properties of α-actinin-3 deficient muscle demonstrating that in some aspects the mutant fast-twitch muscle behaves like a slow-twitch muscle, relaxing and fatiguing more slowly than its wild-type counterpart and also that the mutation renders fast-twitch muscle fibres cold acclimatised and pre-endurances trained; which may explain the positive selection pressures on the mutation over the last 100,000 years of human evolution.

SUMMARY OF RESEARCH ACHIEVEMENTS:- Between 1990 and 1993 Dr Head was among the first researchers to investigate the [Ca2+ ]i handling and electrophysiological properties of two muscular dystrophies which lacked the cytoskeleton proteins laminin α-2 and dystrophin, respectively. These papers are still cited in current reviews on contractile properties and [Ca2+]i handling in muscular dystrophies. More recently Dr Heads has continued his research into contractile and calcium deficiencies which result when cytoskeletal proteins are absent from excitable cells Dr Head’s research group has been invited to talk and participate at international conferences in Paris (France) and Philadelphia (USA) to present on the role played by the cytoskeletal protein “dystrophin” in [Ca2+]i handling of neural tissues and contractile properties of skeletal muscle. As a further recognition of Dr Head’s international standing in this research area of cellular [Ca2+]i regulation and contractile properties of muscle cells, he was appointed to a Visiting Professorship at the University of Liverpool UK (During 2006) . Dr Head has supervised 8 PhD students.

Research

Research Activity Links:

The effects of α-actinin-3 on muscle metabolism, human health and disease

Field of Research (FOR) Tag:

Animal Physiology - Cell

Animal Physiology - Biophysics

Animal Neurobiology

Socio-economic Objective (SEO) tags:

Biological sciences

Expanding Knowledge in the Medical and Health Sciences

Publications related to this Person

Book Chapters

Friedrich O; Head SI, 2017, 'Quantitative ratiometric Ca²⁺imaging to assess cell viability', in Methods in Molecular Biology, pp. 171 - 193, http://dx.doi.org/10.1007/978-1-4939-6960-9_14

Head S, 2012, 'A Two Stage Model of Skeletal Muscle Necrosis in Muscular Dystrophy - The Role of Fiber Branching in the Terminal Stage', in Hegde M; Ankala A (ed.), Muscular Dystrophy, INTECH, Croatia, pp. 475 - 498, http://www.intechopen.com/books/muscular-dystrophy

Head S; Anderson JL; Morley JW, 2012, 'Duchenne Muscular Dystrophy and Brain Function', in Hegde M; Ankala A (ed.), Muscular Dystrophy, InTech, Croatia, pp. 91 - 121, http://dx.doi.org/10.5772/24928

Journal articles

Haug M; Reischl B; Nübler S; Kiriaev L; Mázala DAG; Houweling PJ; North KN; Friedrich O; Head SI, 2021, 'Absence of the Z-disc Protein α-actinin-3 Impairs the Mechanical Stability of Actn3KO Mouse Fast- twitch Muscle Fibres without Altering their Contractile Properties or Twitch Kinetics', , http://dx.doi.org/10.21203/rs.3.rs-1062721/v1

Kiriaev L; Kueh S; Morley JW; Houweling PJ; Chan S; North KN; Head SI, 2021, 'Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse', American Journal of Physiology - Cell Physiology, vol. 321, pp. C704 - C720, http://dx.doi.org/10.1152/ajpcell.00122.2021

Kiriaev L; Perry BD; Mahns DA; Shortland PJ; Redwan A; Morley JW; Head SI, 2021, 'Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes', Frontiers in Physiology, vol. 12, pp. 696039, http://dx.doi.org/10.3389/fphys.2021.696039

Kiriaev L; Kueh S; Morley JW; North KN; Houweling PJ; Head SI, 2020, 'Isolated extensor digitorum longus muscles from old mdx dystrophic mice show little force recovery 120 minutes after eccentric damage', The FASEB Journal, vol. 34, pp. 1 - 1, http://dx.doi.org/10.1096/fasebj.2020.34.s1.00260

Kiriaev L; Kueh S; Morley JW; North KN; Houweling PJ; Head SI, 2020, 'Isolated Extensor Digitorum Longus Muscles from Old mdx Dystrophic Mice Show Little Force Recovery 120 Minutes after Eccentric Damage', Biophysical Journal, vol. 118, pp. 121a - 121a, http://dx.doi.org/10.1016/j.bpj.2019.11.801

Friedrich O; Haug M; Reischl B; Prölß G; Kiriaev L; Head SI; Reid MB, 2019, 'Single muscle fibre biomechanics and biomechatronics – The challenges, the pitfalls and the future', International Journal of Biochemistry and Cell Biology, vol. 114, http://dx.doi.org/10.1016/j.biocel.2019.105563

Kiriaev L; Kueh S; Morley JW; North KN; Houweling PJ; Head SI, 2018, 'Branched fibers from old fast-twitch dystrophic muscles are the sites of terminal damage in muscular dystrophy', American Journal of Physiology - Cell Physiology, vol. 314, pp. C662 - C674, http://dx.doi.org/10.1152/ajpcell.00161.2017

Garton FC; Houweling PJ; Vukcevic D; Meehan LR; Lee FXZ; Lek M; Roeszler KN; Hogarth MW; Tiong CF; Zannino D; Yang N; Leslie S; Gregorevic P; Head SI; Seto JT; North KN, 2018, 'The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance', American Journal of Human Genetics, vol. 102, pp. 845 - 857, http://dx.doi.org/10.1016/j.ajhg.2018.03.009

Haug M; Reischl B; Prölß G; Pollmann C; Buckert T; Keidel C; Schürmann S; Hock M; Rupitsch S; Heckel M; Pöschel T; Scheibel T; Haynl C; Kiriaev L; Head SI; Friedrich O, 2018, 'The MyoRobot: A novel automated biomechatronics system to assess voltage/Ca²⁺ biosensors and active/passive biomechanics in muscle and biomaterials', Biosensors and Bioelectronics, vol. 102, pp. 589 - 599, http://dx.doi.org/10.1016/j.bios.2017.12.003

Head SI, 2017, 'Antioxidant therapy in a mouse model of Duchenne muscular dystrophy: some promising results but with a weighty caveat', Journal of Physiology, vol. 595, pp. 7015, http://dx.doi.org/10.1113/JP275232

Hogarth MW; Houweling PJ; Thomas KC; Gordish-Dressman H; Bello L; Pegoraro E; Hoffman EP; Head SI; North KN, 2017, 'Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy', Nature Communications, vol. 8, http://dx.doi.org/10.1038/ncomms14143

Hogarth MW; Garton FC; Houweling PJ; Tukiainen T; Lek M; Macarthur DG; Seto JT; Quinlan KGR; Yang N; Head SI; North KN, 2016, 'Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion', Human Molecular Genetics, vol. 25, pp. 866 - 877, http://dx.doi.org/10.1093/hmg/ddv613

Cooper ST; Head SI, 2015, 'Membrane Injury and Repair in the Muscular Dystrophies', Neuroscientist, vol. 21, pp. 653 - 668, http://dx.doi.org/10.1177/1073858414558336

Houweling P; Seto J; Garton F; Quinlan K; Head S; North K, 2015, 'A gene for speed: The influence of ACTN3 on muscle performance in health and disease', NEUROMUSCULAR DISORDERS, vol. 25, pp. S185 - S185, http://dx.doi.org/10.1016/j.nmd.2015.06.011

Head SI; Chan S; Houweling PJ; Quinlan KGR; Murphy R; Wagner S; Friedrich O; North KN, 2015, 'Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution', PLoS genetics, vol. 11, pp. e1004862, http://dx.doi.org/10.1371/journal.pgen.1004862

Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0099024

Head SI; Houweling PJ; Chan S; Chen G; Hardeman EC, 2014, 'Properties of regenerated mouse extensor digitorum longus muscle following notexin injury', Experimental Physiology, vol. 99, pp. 664 - 674, http://dx.doi.org/10.1113/expphysiol.2013.077289

Head SI; Arber MB, 2013, 'An active learning mammalian skeletal muscle lab demonstrating contractile and kinetic properties of fast- and slow-twitch muscle', American Journal of Physiology - Advances in Physiology Education, vol. 37, pp. 405 - 414, http://dx.doi.org/10.1152/advan.00155.2012

Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, vol. 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143

Head S, 2012, 'Does skeletal muscle fiber branching play a role in the inability of old EDL dystrophic muscle to resist large passive stretches?', Journal of Applied Physiology, vol. 112, pp. 331, http://dx.doi.org/10.1152/japplphysiol.01355.2011

Chan S; Head SI, 2011, 'The role of branched fibres in the pathogenesis of Duchenne muscular dystrophy', Experimental Physiology, http://dx.doi.org/10.1113/expphysiol.2010.056713

Head SI; Greenaway B; Chan SM, 2011, 'Incubating Isolated Mouse EDL Muscles with Creatine Improves Force Production and Twitch Kinetics in Fatigue Due to Reduction in Ionic Strength', PLoS One, vol. 6, pp. 1 - 8, http://dx.doi.org/10.1371/journal.pone.0022742

Head SI; Chan SM, 2011, 'The role of branched fibres in the pathogenesis of Duchenne muscular dystrophy', Experimental Physiology, vol. 96, pp. 564 - 571, http://dx.doi.org/10.1113/expphysiol.2010.056713

Chan SM; Seto JT; Houweling PJ; Yang N; North K; Head SI, 2011, 'Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female ACTN3 knockout mice', Muscle and Nerve, vol. 43, pp. 37 - 48, http://dx.doi.org/10.1002/mus.21778

Kueh SL; Dempster JA; Head SI; Morley JW, 2011, 'Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse', Neurobiology of Disease, vol. 43, pp. 558 - 564, http://dx.doi.org/10.1016/j.nbd.2011.05.002

Nikolova V; Leimena C; Xiao X; Kesteven SH; Tan J; Yeo LS; Yu ZY; Zhang Q; Carlton A; Head SI; Shanahan C; Feneley MP; Fatkin D, 2011, 'Nesprin-1 and actin contribute to nuclear and cytoskeletal defects in lamin A/C-deficient cardiomyopathy', Journal of Molecular and Cellular Cardiology, vol. 50, pp. 479 - 486, http://dx.doi.org/10.1016/j.yjmcc.2010.12.001

Seto JT; Lek M; Quinlan KG; Houweling PJ; Zheng XF; Garton F; MacArthur DG; Raftery JM; Garvey SM; Hauser MA; Yang N; Head SI; North K, 2011, 'Deficiency of alpha-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling', Human Molecular Genetics, vol. 20, pp. 2914 - 2927, http://dx.doi.org/10.1093/hmg/ddr196

Head SI, 2011, 'Old men still have the skeletal muscle contractile function to get up and go even after they have had their leg in a cast.', The Journal of Physiology, vol. 589, pp. 4639 - 4640, http://dx.doi.org/10.1113/jphysiol.2011.218826

Head SI; Ha TN, 2011, 'Acute inhibitory effects of clenbuterol on force, Ca2+ transients and action potentials in rat soleus may not involve the â2-adrenoceptor pathway', Clinical and Experimental Pharmacology and Physiology, vol. 38, pp. 638 - 646, http://dx.doi.org/10.1111/j.1440-1681.2011.05574.x

Chan SM; Head SI, 2010, 'Age- and Gender-Related Changes in Contractile properties of non-atrophied EDL muscle', PLoS One, vol. 5, pp. 1 - 10, http://dx.doi.org/10.1371/journal.pone.0012345

Anderson JL; Morley JW; Head SI, 2010, 'Enhanced homosynaptic LTD in cerebellar Purkinje cells of the dystrophic MDX mouse', Muscle and Nerve, vol. 41, pp. 329 - 334, http://dx.doi.org/10.1002/mus.21467

Head SI, 2010, 'Branched fibres in old dystrophic mdx muscle are associated with mechanical weakening of the sarcolemma, abnormal Ca2+ transients and a breakdown of Ca2+ homeostasis during fatigue.', Experimental Physiology, vol. 95, pp. 641 - 656, http://dx.doi.org/10.1113/expphysiol.2009.052019

Chan SM; Seto J; MacArthur D; Yang N; North K; Head SI, 2008, 'A gene for speed: contractile properties of isolated whole EDL muscle from an alpha-actinin-3 knockout mouse', American Journal of Physiology - Cell Physiology, vol. 295, pp. C897 - C904, http://dx.doi.org/10.1152/ajpcell.00179.2008

MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380

Kueh SL; Head SI; Morley JW, 2008, 'GABA(A) receptor expression and inhibitory post-synaptic currents in cerebellar purkinje cells in dystrophin-deficient mdx mice', Clinical and Experimental Pharmacology and Physiology, vol. 35, pp. 207 - 210, http://dx.doi.org/10.1111/j.1440-1681.2007.04816.x

Chan SM; Head SI; Morley JW, 2007, 'Branched fibers in dystrophic mdx muscle are associated with a loss of force following lengthening contractions', American Journal of Physiology - Cell Physiology, vol. 293, pp. C985 - C992, http://dx.doi.org/10.1152/ajpcell.00128.2007

Anderson JL; Head SI; Morley JW, 2005, 'Synaptic plasticity in the dy2J mouse model of laminin [alpha]2-deficient congenital muscular dystrophy', Brain Research, vol. 1042, pp. 23 - 28, http://dx.doi.org/10.1016/j.brainres.2005.02.001

Bakker AJ; Parkinson A; Head SI, 2005, 'Contractile properties of single-skinned skeletal muscle fibres of the extensor digitorum longus muscle of the Australian short-nosed echidna', Australian Journal of Zoology, vol. 53, pp. 237 - 240, http://dx.doi.org/10.1071/ZO05011

Anderson JL; Head SI; Morley JW, 2004, 'Long-term depression is reduced in cerebellar Purkinje cells of dystrophin-deficient mdx mice', Brain Research, vol. 1019, pp. 289 - 292, http://dx.doi.org/10.1016/j.brainres.2004.06.011

Head SI; Liangas G; Bakker AJ, 2004, 'EDL and soleus muscles of the C57BL6J/dy(2j) laminin-alpha(2)-deficientdystrophic mouse are not vulnerable to eccentric contractions', Experimental Physiology, vol. 89, pp. 531 - 539, http://dx.doi.org/10.1113/expphysiol.2004.027383

Yeung EW; Head SI; Allen DG, 2003, 'Gadolinium reduces short-term stretch-induced muscle damage in isolated mdx mouse muscle fibres', Journal of Physiology, vol. 552, pp. 449 - 458, http://dx.doi.org/10.1113/jphysiol.2003.047373

Head S, 2003, 'Smoke free hospitals - Smoke free hospitals are unethical', BRITISH MEDICAL JOURNAL, vol. 327, pp. 104 - 104, http://dx.doi.org/10.1136/bmj.327.7406.104-a

Burrell JH; Boyn AM; Kumarasamy V; Hsieh A; Head SI; Lumbers ER, 2003, 'Growth and Maturation of Cardiac Myocytes in Fetal Sheep in the Second Half of Gestation', Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, vol. 274, pp. 952 - 961, http://dx.doi.org/10.1002/ar.a.10110

Rae C; Griffin JL; Blair DH; Bothwell JH; Bubb WA; Maitland A; Head S, 2002, 'Abnormalities in brain biochemistry associated with lack of dystrophin: Studies of the mdx mouse', Neuromuscular Disorders, vol. 12, pp. 121 - 129, http://dx.doi.org/10.1016/S0960-8966(01)00253-X

Anderson JL; Head SI; Rae CD; Morley JW, 2002, 'Brain Function in Duchenne muscular dystrophy', Brain, vol. 125, pp. 4 - 13, http://dx.doi.org/10.1093/brain/awf012

Anderson JL; Williams GD; Head SI, 2001, 'The Role of Nitric Oxide in Diaphragmatic Dysfunction in Endotoxemic Rats', Muscle and Nerve, vol. 24, pp. 30 - 36, http://dx.doi.org/10.1002/1097-4598(200101)24:1<30::AID-MUS3>3.0.CO;2-W

Parkinson A; Bakker AJ; Head SI, 2001, 'Morphology and organization of muscle fibres in the thoracic coxal muscle receptor organ and the associated promotor muscle, in a crayfish, Cherax destructor, and mud crab, Scylla serrata', ACTA Zoologica, vol. 82, pp. 251 - 260, http://dx.doi.org/10.1046/j.1463-6395.2001.00088.x

Blazev R; Hussain M; Bakker AJ; Head SI; Lamb GD, 2001, 'Effects of the PKA inhibitor H-89 on excitation-contraction coupling in skinned and intact skeletal muscle fibres', Journal of Muscle Research and Cell Motility, vol. 22, pp. 277 - 286, https://www.ncbi.nlm.nih.gov/pubmed/11763200

Parkinson AL; Bakker AJ; Head SI, 2000, 'Ca²⁺- and Sr²⁺-activation properties of muscle fibres from a muscle receptor organ and the associated extrafusal muscle of the crab and crayfish', Journal of Muscle Research and Cell Motility, vol. 21, pp. 663 - 671, http://dx.doi.org/10.1023/A:1005656528208

Parkinson AL; Bakker AJ; Head SI, 2000, 'Morphology and organization of muscle fibres in the thoracic coxal muscle receptor organ and the associated promotor muscle, in a crayfish, Cherax destructor, and mud crab, Scylla serrata', Acta Zoologica, vol. 82, pp. 251 - 251, http://dx.doi.org/10.1046/j.1463-6395.2000.00088.x

Bakker AJ; Head SI; Wareham AC; Stephenson DG, 1998, 'Effect of clenbuterol on sarcoplasmic reticulum function in single skinned mammalian skeletal muscle fibers', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, vol. 274, pp. C1718 - C1726, http://dx.doi.org/10.1152/ajpcell.1998.274.6.C1718

Majeed A; Head S, 1998, 'Capitation based prescribing budgets will not work', BRITISH MEDICAL JOURNAL, vol. 316, pp. 748 - 750, http://dx.doi.org/10.1136/bmj.316.7133.748

Head SI; Bakker AJ; Wareham AC; Stephenson DK, 1998, 'Effect of clenbuterol on sarcoplasmic reticulum function in single skinned mammalian skeletal muscle fibres', American Journal of Physiology - Cell Physiology, vol. 274, pp. C1718 - C1726

Hussain M; Bakker AJ; Head SI, 1997, 'Effects of protein kinase A (PKA) inhibition on excitation-contraction coupling (ECC) in isolated fast-twitch mouse skeletal muscle.', JOURNAL OF PHYSIOLOGY-LONDON, vol. 504P, pp. P233 - P233, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997YJ42400315&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Bakker AJ; Head SI; Stephenson G, 1997, 'Time course of calcium transients derived from fura-2 fluorescence measurements in single fast twitch fibres of adult mice and rat myotubules developing in primary culture.', Cell Calcium, vol. 21, pp. 359 - 364, http://dx.doi.org/10.1016/S0143-4160(97)90029-4

Bakker AJ; Head SI; Stephenson DK, 1996, 'Measurement of membrane potential and myoplasmic (Ca2+) in developing rat myotubes at rest and in response to stimulation', Cell Calcium, vol. 19, pp. 409 - 418, http://dx.doi.org/10.1016/S0143-4160(96)90114-1

HEAD S, 1994, 'PRIVATISATION OF NHS PRESCRIBING', BRITISH MEDICAL JOURNAL, vol. 309, pp. 957 - 957, http://dx.doi.org/10.1136/bmj.309.6959.957a

Bordas J; Lewy J; Head S; Williams D; Stephenson G; Moens P; Baatsen P; Maréchal G, 1994, 'Correspondence', Journal of Muscle Research and Cell Motility, vol. 15, pp. 489 - 492, http://dx.doi.org/10.1007/BF00122122

HEAD S; WILLIAMS D; STEPHENSON G, 1994, 'UNTITLED', JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, vol. 15, pp. 490 - 491, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994PC80100012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HUSSAIN M; WAREHAM AC; HEAD SI, 1994, 'MECHANISM OF ACTION OF A K+ CHANNEL ACTIVATOR BRL-38227 ON ATP-SENSITIVE K+ CHANNELS IN MOUSE SKELETAL-MUSCLE FIBERS', JOURNAL OF PHYSIOLOGY-LONDON, vol. 478, pp. 523 - 532, http://dx.doi.org/10.1113/jphysiol.1994.sp020271

Head S; Williams D; Stephenson G; Moens P; Baatsen P; Marechal G, 1994, 'Letter to the editor [2]', Journal of Muscle Research and Cell Motility, vol. 15, pp. 490 - 491

Head SI, 1993, 'Membrane potential, resting calcium and calcium transients in isolated muscle fibres from normal and dystrophic mice.', The Journal of Physiology, vol. 469, pp. 11 - 19, http://dx.doi.org/10.1113/jphysiol.1993.sp019801

BAKKER AJ; HEAD SI; WILLIAMS DA; STEPHENSON DG, 1993, 'CA-2+ LEVELS IN MYOTUBES GROWN FROM THE SKELETAL-MUSCLE OF DYSTROPHIC (MDX) AND NORMAL MICE', JOURNAL OF PHYSIOLOGY-LONDON, vol. 460, pp. 1 - 13, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993KG92100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

WILLIAMS DA; HEAD SI; LYNCH GS; STEPHENSON DG, 1993, 'CONTRACTILE PROPERTIES OF SKINNED MUSCLE-FIBERS FROM YOUNG AND ADULT NORMAL AND DYSTROPHIC (MDX) MICE', JOURNAL OF PHYSIOLOGY-LONDON, vol. 460, pp. 51 - 67, http://dx.doi.org/10.1113/jphysiol.1993.sp019458

HEAD SI; WILLIAMS DA; STEPHENSON DG, 1992, 'ABNORMALITIES IN STRUCTURE AND FUNCTION OF LIMB SKELETAL-MUSCLE FIBERS OF DYSTROPHIC MDX MICE', PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, vol. 248, pp. 163 - 169, http://dx.doi.org/10.1098/rspb.1992.0058

HEAD SI; BUSH BMH, 1992, 'PROPRIOCEPTIVE INPUT FROM 2 BASAL JOINT STRETCH RECEPTORS TO LEG MOTONEURONS IN THE ISOLATED THORACIC GANGLION OF THE SHORE CRAB', JOURNAL OF EXPERIMENTAL BIOLOGY, vol. 163, pp. 187 - 208, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992HG32000012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

HEAD SI; BUSH BMH, 1991, 'REFLEX ACTIONS OF ONE PROPRIOCEPTOR ON THE MOTONEURONS OF A MUSCLE RECEPTOR AND THEIR CENTRAL MODULATION IN THE SHORE CRAB', JOURNAL OF PHYSIOLOGY-LONDON, vol. 437, pp. 49 - 62, http://dx.doi.org/10.1113/jphysiol.1991.sp018582

HEAD SI; BUSH BMH, 1991, 'PROPRIOCEPTIVE REFLEX INTERACTIONS WITH CENTRAL MOTOR RHYTHMS IN THE ISOLATED THORACIC GANGLION OF THE SHORE CRAB', JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, vol. 168, pp. 445 - 459, http://dx.doi.org/10.1007/BF00199604

WILLIAMS DA; HEAD SI; BAKKER AJ; STEPHENSON DG, 1990, 'RESTING CALCIUM CONCENTRATIONS IN ISOLATED SKELETAL-MUSCLE FIBERS OF DYSTROPHIC MICE', JOURNAL OF PHYSIOLOGY-LONDON, vol. 428, pp. 243 - 256, http://dx.doi.org/10.1113/jphysiol.1990.sp018210

HEAD SI; STEPHENSON DG; WILLIAMS DA, 1990, 'PROPERTIES OF ENZYMATICALLY ISOLATED SKELETAL FIBERS FROM MICE WITH MUSCULAR-DYSTROPHY', JOURNAL OF PHYSIOLOGY-LONDON, vol. 422, pp. 351 - 367, http://dx.doi.org/10.1113/jphysiol.1990.sp017988

Conference Papers

Conference Abstracts

Wagner S; Chan S; Murphy R; Houweling PJ; Quinlan KGR; North KN; Head SI; Friedrich O, 2015, 'Speed of shortening is not altered in the alpha-actinin-3 (ACTN3) 'gene of speed' knock-out mutation in fast-twitch skeletal muscle', in ACTA PHYSIOLOGICA, WILEY-BLACKWELL, Vol. 213, pp. 66 - 66, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000362554200139&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Working Papers

Kiriaev L; Kueh S; Morley JW; North KN; Houweling PJ; Head SI, 2021, Lifespan analysis of dystrophic mdx fast-twitch muscle morphology and its impact on contractile function, Cold Spring Harbor Laboratory, http://dx.doi.org/10.1101/2021.09.07.459226, http://dx.doi.org/10.1101/2021.09.07.459226

Preprints

Ronaldson SM; Stephenson DG; Head SI, 2022, Calcium and strontium contractile activation properties of single skinned skeletal muscle fibres from elderly women 66-90 years of age, http://dx.doi.org/10.21203/rs.3.rs-1643986/v1

Chan S; Kueh SLL; Morley JW; Head SI, 2021, SR Ca²⁺ handling in unbranched, immediately post-necrotic fast-twitch mdx fibres is similar to wt littermates, http://dx.doi.org/10.1101/2021.11.29.470495

Ronaldson SM; Stephenson DG; Head SI, 2021, Calcium and strontium contractile activation properties of single skinned skeletal muscle fibres from elderly women 66-90 years of age, http://dx.doi.org/10.1101/2021.11.08.466855

Haug M; Reischl B; Nübler S; Kiriaev L; Mázala DAG; Houweling PJ; North KN; Friedrich O; Head SI, 2021, Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics, http://dx.doi.org/10.1101/2021.11.09.467867

Kiriaev L; Houweling PJ; North KN; Head SI, 2021, Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching, http://dx.doi.org/10.1101/2021.10.01.462704

Find a Person

Quick Links

	Scholarships
	Contact Us