Associate Professor Kuldip Sidhu | Brain Sciences UNSW

Tabs

Main

University role:

Honorary Associate Professor

Phone:

02 9382 2622

Email:

k.sidhu@unsw.edu.au

Research Interests:
Major focus of research in my lab is to use stem cells from both embryonic and non-embryonic sources and to develop therapeutic applications particularly for Alzheimer's and Parkinson's and other neuronal diseases. We developed a joint-patent protected new hESC line, Endeavour-1 and a cloning technique that could be licenced from SESIAHS for obtaining various lineage specifications. My formal training in this field is from the WiCell, Wisconsin USA with Prof James Thomson, who propagated these cells in 1998 for the first time. My background in research is in the major field of reproductive biology with specialization in cell and molecular biology of gametes/embryos and assisted reproductive technology. The major breakthrough in my research has been the establishment of in vitro fertilization system for the possum, first for any Australian marsupials and the derivation of clones from various hESC lines and their lineage specifications. Recently we have produced an another human embryonic stem cell line from Australia called, Endeavour-2. Currently we have four major research programs, each with associated projects: 1.DEVELOPING A SKIN-TO-NEURON AUTOLOGOUS ADULT STEM CELL TECHNOLOGY 2.TOWARDS DEVELOPING STEM CELLS THERAPIES FOR PARKINSON'S DISEASE 3.GENERATING DISEASE SPECIFIC STEM CELL LINES by iPS CELL TECHNOLOGY AS MODEL TO STUDY ALZHEIMER'S AND PARKINSON'S DISEASE 4.TISSUE ENGINEERING BY USING 3D PROPAGATION OF STEM CELLS USING BIOREACTOR

Broad Research Areas:
Stem Cells, Cell Biology and Gene Regulation

Qualifications:
BSc(Med), PhD

Society Memberships & Professional Activities:
International Society for Stem Cell Research (ISSCR), Fertility Society of Australia (FSA), Society for Reproductive Biology (SRB), Scientists in Reproductive Technology (SIRT), Member, International committee and Travel Grant Committee of ISSCR

Specific Research Keywords:
Stem Cell Biology, Neurodegenerative Diseases, Endocrinology

Research

Research Activity Links:

Field of Research (FOR) Tag:

Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

Animal Neurobiology

Publications related to this Person

Books

Sidhu K, (ed.), 2012, Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench to Bedside, First, Bentham Press, UAE

Book Chapters

Hua J; Zhang S; Wang L; Cao H; Zhu H; Sun J; Hu Y; Sidhu KS, 2012, 'Micro-RNAs, pluripotent stem cells and germ cells: Basic science to clinical applications', in Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, pp. 180 - 190, http://dx.doi.org/10.2174/978160805289911201010180

Lie KH; Chayosumrit M; Hardikar A; Sidhu KS, 2012, 'Pluripotent stem cells and diabetes: Basic science to clinical applications', in Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, pp. 143 - 167, http://dx.doi.org/10.2174/978160805289911201010143

Sidhu KS, 2012, 'The prospects and challenges of cell-based therapies', in Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, pp. 227 - 233, http://dx.doi.org/10.2174/978160805289911201010227

Sidhu KS; Sachdev PS, 2012, 'Pluripotent stem cells & neurodegenerative and ischaemic brain diseases: Basic science to clinical applications', in Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, pp. 95 - 112, http://dx.doi.org/10.2174/978160805289911201010095

Lie KH; Chung HCY; Sidhu KS, 2012, 'Derivation, propagation, and characterization of neuroprogenitors from pluripotent stem cells (hESCs and hiPSCs)', in Methods in Molecular Biology, pp. 237 - 246, http://dx.doi.org/10.1007/978-1-61779-794-1_15

Han J; Chung H; Sachdev PS; Sidhu KS, 2011, 'Epigenetic modifications in reprogramming and lineage specifications from embryonic stem cells: Current trends and relevance in developing regenerative medicine', in Stem Cell, Regenerative Medicine and Cancer, pp. 3 - 29

Han J; Sidhu K, 2011, 'Reprogramming somatic cells by fusion with embryonic stem cells: present status and prospects in regenerative medicine', in Atwood C (ed.), Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, edn. First, INTECH International Press, Austria, pp. 1 - 27

Sidhu KS, 2010, 'Motoneurons from Human Embryonic Stem Cells: Present Status and Future Strategies for their Use in Regenerative Medicine', in Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging, http://dx.doi.org/10.1093/acprof:oso/9780195326697.003.0009

Han J; Sachdev PS; Sidhu K; Chung HC, 2010, 'Epigenetic modifications in reprogramming and lineage specifications from embryonic stem cells: current trends and relevance in developing regenerative medicine', in Singh SR (ed.), Stem Cells, Regenerative Medicine and Cancer, edn. First, Nova Science Publishers, USA, pp. 1 - 27

Sidhu KS; Walke S; Tuch BE, 2008, 'Derivation and propagation of hESC under a therapeutic environment', in Current Protocols in Stem Cell Biology, edn. SUPPL. 6, http://dx.doi.org/10.1002/9780470151808.sc01a04s6

Journal articles

Duncan T; Lowe A; Sidhu K; Sachdev P; Lewis T; Lin RCY; Sytnyk V; Valenzuela M, 2017, 'Replicable Expansion and Differentiation of Neural Precursors from Adult Canine Skin', Stem Cell Reports, vol. 9, pp. 557 - 570, http://dx.doi.org/10.1016/j.stemcr.2017.07.008

Kim J; Sachdev PS; Zhang P; Sidhu K, 2017, 'Stem Cells-Based Therapeutics for Parkinson’s Disease - A Transcriptomic Analyses During Dopaminergic Neuron Differentiation under 3- and 2- Dimensional Environments using Human Embryonic Stem Cells', Journal of Stem Cell Research & Therapeutics, vol. 2, http://dx.doi.org/10.15406/jsrt.2017.02.00052

Balez R; Steiner N; Engel M; Muñoz SS; Lum JS; Wu Y; Wang D; Vallotton P; Sachdev P; O'Connor M, 2016, 'Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep31450

Lowe A; Dalton M; Sidhu K; Sachdev P; Reynolds B; Valenzuela M, 2015, 'Neurogenesis and precursor cell differences in the dorsal and ventral adult canine hippocampus', Neuroscience Letters, vol. 593, pp. 107 - 113, http://dx.doi.org/10.1016/j.neulet.2015.03.017

Hua S; Chung H; Sidhu K, 2014, 'Human therapeutic cloning, pitfalls and lack luster because of rapid developments in induced pluripotent stem cell technology', Asian Biomedicine, vol. 8, pp. 5 - 10, http://dx.doi.org/10.5372/1905-7415.0801.256

Sidhu K, 2013, 'Stem cell translation: A cliff hanger!', Australasian Biotechnology, vol. 23, pp. 22 - 23

Siette J; Westbrook RF; Cotman C; Sidhu K; Zhu W; Sachdev P; Valenzuela MJ, 2013, 'Age-specific effects of voluntary exercise on memory and the older brain', Biological Psychiatry, vol. 73, pp. 435 - 442, http://dx.doi.org/10.1016/j.biopsych.2012.05.034

Kim J; Sachdev P; Sidhu K, 2013, 'Alginate microcapsule as a 3D platform for the efficient differentiation of human embryonic stem cells to dopamine neurons', Stem Cell Research, vol. 11, pp. 978 - 989, http://dx.doi.org/10.1016/j.scr.2013.06.005

Ooi L; Sidhu K; Poljak A; Sutherland G; O'Connor MD; Sachdev P; Münch G, 2013, 'Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease', Journal of Neural Transmission, vol. 120, pp. 103 - 111, http://dx.doi.org/10.1007/s00702-012-0839-2

Sidhu KS; Chayosumrit M; Lie KH, 2012, 'Stem Cells, Definition, Classification and Sources', Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, pp. 3 - 15, http://dx.doi.org/10.2174/978160805289911201010003

Sidhu KS, 2012, 'Preface', Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-to-Bedside, http://dx.doi.org/10.2174/9781608052899112010100ii

Lie KH; Tuch BE; Sidhu KS, 2012, 'Suppression of NANOG induces efficient differentiation of human embryonic stem cells to pancreatic endoderm', Pancreas, vol. 41, pp. 54 - 64, http://dx.doi.org/10.1097/MPA.0b013e31822362e4

Khandekar N; Lie KH; Sachdev PS; Sidhu KS, 2012, 'Amyloid precursor proteins, neural differentiation of pluripotent stem cells and its relevance to Alzheimer's disease', Stem Cells and Development, vol. 21, pp. 997 - 1006, http://dx.doi.org/10.1089/scd.2011.0564

Sidhu K; Kim J; Chayosumrit M; Dean S; Sachdev P, 2012, 'Alginate microcapsule as a 3D platform for propagation and differentiation of human embryonic stem cells (hESC) to different lineages.', Journal of visualized experiments : JoVE

Chung HCY; Lin RCY; Logan GJ; Alexander IE; Sachdev PS; Sidhu KS, 2012, 'Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles', Stem Cells and Development, vol. 21, pp. 206 - 216, http://dx.doi.org/10.1089/scd.2010.0440

Hua J; Sidhu KS, 2011, 'Coaxing HESC to form oocyte-like structures by co-culture with testicular extract and hormones', Open Stem Cell Journal, vol. 3, pp. 34 - 45, http://dx.doi.org/10.2174/1876893801103010034

Sidhu KS, 2011, 'Present status and future trends in adult and embryonic stem cell research', Open Stem Cell Journal, vol. 3, pp. 1 - 3, http://dx.doi.org/10.2174/1876893801103010001

Sidhu KS, 2011, 'Induced pluripotent stem cells, a slippery slope for neurodegenerative disease modelling?', Open Stem Cell Journal, vol. 3, pp. 46 - 51, http://dx.doi.org/10.2174/1876893801103010046

Chayosumrit M; Hardikar AA; Sidhu KS, 2011, 'Role of the glucagon-like peptide-1 receptor agonist in maintaining pluripotency in human embryonic stem cells', Open Stem Cell Journal, vol. 3, pp. 11 - 22, http://dx.doi.org/10.2174/1876893801103010011

Sidhu KS, 2011, 'New approaches for the generation of induced pluripotent stem cells', Expert Opinion on Biological Therapy, vol. 11, pp. 569 - 579, http://dx.doi.org/10.1517/14712598.2011.558837

Han J; Sidhu K, 2011, 'Embryonic stem cell extracts: Use in differentiation and reprogramming', Regenerative Medicine, vol. 6, pp. 215 - 227, http://dx.doi.org/10.2217/rme.11.8

Amps K; Andrews PW; Anyfantis G; Armstrong L; Avery S; Baharvand H; Baker J; Baker D; Munoz MB; Beil S, 2011, 'Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage', Nature Biotechnology, vol. 29, pp. 1132 - 1144, http://dx.doi.org/10.1038/nbt.2051

Hua J; Tuch BE; Sidhu K, 2011, 'Coaxing hESC to form oocyte-like structures by co-culture with testicular extract and hormones.', The Open Stem Cell Journal, vol. 3, pp. 45, http://www.benthamscience.com/open/toscj/articles/V003/SI0001TOSCJ/34TOSCJ.pdf

Chayosumrit M; Tuch B; Sidhu K, 2010, 'Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.', Biomaterials, vol. 31, pp. 505 - 514, http://dx.doi.org/10.1016/j.biomaterials.2009.09.071

Sidhu KS; Ryan JP; Lees JG; Tuch BE, 2010, 'Derivation of a new human embryonic stem cell line, Endeavour-2, and its characterization', In Vitro Cellular and Developmental Biology - Animal, vol. 46, pp. 269 - 275, http://dx.doi.org/10.1007/s11626-010-9280-8

Han J; Sachdev PS; Sidhu KS, 2010, 'A combined epigenetic and non-genetic approach for reprogramming human somatic cells', PLoS ONE, vol. 5, http://dx.doi.org/10.1371/journal.pone.0012297

Hua J; Pan S; Yang C; Dong W; Dou Z; Sidhu KS, 2009, 'Derivation of male germ cell-like lineage from human fetal bone marrow stem cells', Reproductive BioMedicine Online, vol. 19, pp. 99 - 105, http://dx.doi.org/10.1016/S1472-6483(10)60052-1

Sidhu KS; Ryan JP; Tuch BE, 2008, 'Derivation of a new human embryonic stem cell line, endeavour-1, and its clonal propagation', Stem Cells and Development, vol. 17, pp. 41 - 51, http://dx.doi.org/10.1089/scd.2007.0055

Hua J; Sidhu K, 2008, 'Recent advances in the derivation of germ cells from the embryonic stem cells', Stem Cells and Development, vol. 17, pp. 399 - 411, http://dx.doi.org/10.1089/scd.2007.0225

Valenzuela MJ; Dean SK; Sachdev P; Tuch BE; Sidhu KS, 2008, 'Neural precursors from canine skin: A new direction for testing autologous cell replacement in the brain', Stem Cells and Development, vol. 17, pp. 1087 - 1094, http://dx.doi.org/10.1089/scd.2008.0008

Han J; Sidhu KS, 2008, 'Current concepts in reprogramming somatic cells to pluripotent state', Current Stem Cell Research and Therapy, vol. 3, pp. 66 - 74, http://dx.doi.org/10.2174/157488808783489480

Sidhu K; Han J, 2008, 'Current concepts in reprogramming somatic cells in pluripotent state', Current Stem Cell Research and Therapy, vol. 3, pp. 66 - 74

Sidhu K; Ryan J; Tuch BE, 2008, 'Derivation of a new hESC line, endeavour - 1 and its clonal propagation', Stem Cells and Development, vol. 17, pp. 41 - 51

Valenzuela M; Sidhu K; Dean S; Sachdev P, 2007, 'Neural stem cell therapy for neuropsychiatric disorders', Acta Neuropsychiatrica, vol. 19, pp. 11 - 26, http://dx.doi.org/10.1111/j.1601-5215.2007.00176.x

Hardikar AA; Lees JG; Sidhu KS; Colvin E; Tuch BE, 2006, 'Stem-cell therapy for diabetes cure: how close are we?', Current stem cell research & therapy, vol. 1, pp. 425 - 436, http://dx.doi.org/10.2174/157488806778226830

Sidhu KS; U-Ming L; Gorrie C; Waite P; Tuch BE, 2006, 'Derivation of neural progenitor cells from human embryonic stem cells for transplantation to spinal cord injury rat model', CYTOMETRY PART A, vol. 69A, pp. 425 - 426, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000237187700093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Sidhu KS; Tuch BE, 2006, 'Derivation of three clones from human embryonic stem cell lines by FACS sorting and their characterization', Stem Cells and Development, vol. 15, pp. 61 - 69, http://dx.doi.org/10.1089/scd.2006.15.61

Sidhu KS; Lie KHD; Tuch BE, 2006, 'Transgenic human fetal fibroblasts as feeder layer for human embryonic stem cell lineage selection', Stem Cells and Development, vol. 15, pp. 741 - 747, http://dx.doi.org/10.1089/scd.2006.15.741

Khoo MLM; McQuade LR; Smith MSR; Lees JG; Sidhu KS; Tuch BE, 2006, 'Erratum: Growth and differentiation of embryoid bodies derived from human embryonic stem cells: Effect of glucose and basic fibroblast growth factor (Biology of Reproduction (2005) 73 (1147-1156) DOI:', Biology of Reproduction, vol. 74, pp. 448, http://dx.doi.org/10.1095/biolreprod.105.050088

Dean SK; Yulyana Y; Williams G; Sidhu KS; Tuch BE, 2006, 'Differentiation of encapsulated embryonic stem cells after transplantation', Transplantation, vol. 82, pp. 1175 - 1184, http://dx.doi.org/10.1097/01.tp.0000239518.23354.64

Tuch BE; Hardikar AA; Lees JG; Sidhu K; Colvin EK, 2006, 'Stem-Cell therapy for diabetes cure: How close are we?', Current Stem Cell Research and Therapy, vol. 1, pp. 231 - 238

Lim U; Sidhu K; Tuch BE, 2006, 'Derivation of motor neurons from three clonal human embryonic stem cell lines', CURRENT NEUROVASCULAR RESEARCH, vol. 3, pp. 128 - 188

Khoo MLM; McQuade LR; Smith MSR; Lees JG; Sidhu KS; Tuch BE, 2005, 'Growth and differentiation of embryoid bodies derived from human embryonic stem cells: Effect of glucose and basic fibroblast growth factor', Biology of Reproduction, vol. 73, pp. 1147 - 1156, http://dx.doi.org/10.1095/biolreprod.104.036673

Sidhu KS; Mate KE; Gunasekera T; Veal D; Hetherington L; Baker MA; Aitken RJ; Rodger JC, 2004, 'A flow cytometric assay for global estimation of tyrosine phosphorylation associated with capacitation of spermatozoa from two marsupial species, the tammar wallaby (Macropus eugenii) and the brushtai', Reproduction, vol. 127, pp. 95 - 103, http://dx.doi.org/10.1530/rep.1.00073

Sidhu K, 'Perils of Stem Cell Translation: A Commentary', Journal of Stem Cell Research & Therapy, vol. 04, http://dx.doi.org/10.4172/2157-7633.1000167

Conference Abstracts

Lowe A; Sidhu K; Sachdev PS; Valenzuela M, 2013, 'Adult canine skin-derived and brain-derived neuroprecursors: an in vitro comparison [Abstract POS-TUE-001]', in Proceedings of the 2013 Australian Neuroscience Society Annual Meeting., Australian Neuroscience Society Annual Meeting 2013, Melbourne, Australia, pp. 135 - 135, presented at Australian Neuroscience Society Annual Meeting 2013, Melbourne, Australia, 03 - 06 February 2013

Valenzuela M; Siette J; Westbrook F; Sidhu K; Cotman C; Sachdev P, 2011, 'Cell therapy plus voluntary running rescues memory dysfunction in a rodent model of brain ageing [Abstract P4-443]', in Alzheimer's & Dementia, Alzheimers Association International Conference (AAIC) 2011, Paris, France, Vol. 7, pp. e65 - e66, presented at Alzheimers Association International Conference (AAIC) 2011, Paris, France, 16 - 21 July 2011, http://dx.doi.org/10.1016/j.jalz.2011.09.139

Lowe A; Dalton MA; Sachdev PS; Sidhu K; Valenzuela MJ, 2010, 'Adult canine neurogenesis: A dorsal versus ventral hippocampal gradient? [Abstract]', in Proceedings of the Australian Society for Psychiatric Research (ASPR) 2010 Conference, Australian Society for Psychiatric Research (ASPR) 2010 Conference ”Glial-Neuronal Networks in Neuropsychiatry”, Sydney, Australia, presented at Australian Society for Psychiatric Research (ASPR) 2010 Conference â€Glial-Neuronal Networks in Neuropsychiatryâ€, Sydney, Australia, 05 - 08 December 2012

Valenzuela M; Dean S; Mak B; Bailey G; Westbrook F; Sachdev P; Sidhu K, 2008, 'Survival and differentiation of adult skin-derived neuroprecursors in a rat model of age-related cognitive impairment [Abstract P2-470]', in Alzheimer's & Dementia, Alzheimers Association International Conference (AAIC) 2008, Chicago, Illinois, USA, Vol. 4, pp. T512 - T512, presented at Alzheimers Association International Conference (AAIC) 2008, Chicago, Illinois, USA, 26 - 31 July 2008, http://dx.doi.org/10.1016/j.jalz.2008.05.1549

Find a Person

Quick Links

	Scholarships
	Contact Us