Associate Professor Kay Double
Tabs
Publications related to this Person
Books
Gerlach M; Deckert J; Double KL; Koutsilieri E, (eds.), 2007, Neuropsychiatric Disorders An Integrative Approach - Journal of Neural Transmission Supplement 72, Springer-Verlag, Vienna
Book Chapters
Halliday GM; Reyes S; Double KL, 2012, 'Substantia Nigra, Ventral Tegmental Area and Retrorubral Fields', in Mai JK; Paxinos G (ed.), The Human Nervous System, Academic Press, London, pp. 439 - 455, http://dx.doi.org/10.1016/B978-0-12-374236-0.10013-6
Double KL; Maruyama W; Naoi M; Gerlach M; Riederer P, 2011, 'Biological role of neuromelanin in the human brain and its importance in Parkinson's disease', in Borovansky J; Riley PA (ed.), Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological and Pathological Functions, Wiley-Blackwell, Wienheim, Germany, pp. 225 - 246, http://dx.doi.org/10.1002/9783527636150.ch8
Gerlach M; Double KL; Gotz ME; Youdim MB; Riederer P, 2006, 'The role of iron in the pathogenesis of Parkinson`s disease', in Metal Ions in Life Sciences, Volume 1: Neurodegenerative Diseases and Metal Ions, edn. 1, John Wiley & Sons, Chichester, West Sussex, pp. 125 - 149
Double KL, 2004, 'Encouraging the return of young biomedical scientists to Australia: a personal perspective', in Wood FQ (ed.), Beyond Brain Drain: Mobility, Competitiveness and Scientific Excellence, edn. Original, Federation of Australian Scientific and Technological Societies, Armidale, Australia, pp. 149 - 153
Double KL; Jellinger K; Zecca L; Youdim MB; Riederer P; Gerlach M, 2003, 'Iron, neuromelanin, and alpha-synuclein in neuropathogenesis of Parkinson`s disease', in Zatta P (ed.), Metal Ions and Neurodegenerative Disorders, edn. 1, World Scientific Publishing, Singapore, pp. 343 - 364
Double KL; Gerlach M; Youdim MB; Riederer P, 2000, 'Impaired iron homeostasis in Parkinson`s disease', in Advances in Research on Neurodegeneration, Springer Publishing Company, Vienna, pp. 37 - 58
Harper C; Sheedy D; Halliday GM; Double KL; Dodd P; Lowehl JM; Kril J, 1998, 'Neuropathological studies: the relationship between alcohol and ageing', in NIAAA Research monograph 33: Alcohol Problems and Aging, edn. Original, US Department of Health and Human Services, Bethesda, MD USA, pp. 117 - 134
Journal articles
Virachit S; Mathews KJ; Cottam V; Werry E; Galli E; Rappou E; Lindholm P; Saarma M; Halliday GM; Shannon Weickert C; Double KL, 2019, 'Levels of glial cell line-derived neurotrophic factor are decreased, but fibroblast growth factor 2 and cerebral dopamine neurotrophic factor are increased in the hippocampus in Parkinson’s disease', Brain Pathology, vol. 29, pp. 813 - 825, http://dx.doi.org/10.1111/bpa.12730
Weissleder C; Barry G; Fung SJ; Wong MW; Double KL; Webster MJ; Weickert CS, 2019, 'Reduction in IGF1 mRNA in the human subependymal zone during aging', Aging and Disease, vol. 10, pp. 197 - 204, http://dx.doi.org/10.14336/AD.2018.0317
Mathews KJ; Allen KM; Boerrigter D; Ball H; Shannon Weickert C; Double KL, 2017, 'Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers', Aging Cell, vol. 16, pp. 1195 - 1199, http://dx.doi.org/10.1111/acel.12641
Genoud S; Roberts BR; Gunn AP; Halliday GM; Lewis SJG; Ball HJ; Hare DJ; Double KL, 2017, 'Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain', Metallomics, vol. 9, pp. 1447 - 1455, http://dx.doi.org/10.1039/c7mt00244k
Trist BG; Davies KM; Cottam V; Genoud S; Ortega R; Roudeau S; Carmona A; De Silva K; Wasinger V; Lewis SJG; Sachdev PS; Smith B; Troakes C; Vance C; Shaw C; Al-Sarraj S; Ball HJ; Halliday GM; Hare DJ; Double KL, 2017, 'Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain', Acta Neuropathologica, vol. 134, pp. 113 - 127, http://dx.doi.org/10.1007/s00401-017-1726-6
Purves-Tyson TD; Owens SJ; Rothmond DA; Halliday GM; Double KL; Stevens J; McCrossin T; Shannon Weickert C, 2017, 'Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain', Translational Psychiatry, vol. 7, http://dx.doi.org/10.1038/tp.2016.257
Tan B; Double KL; Burne J; Diong J, 2016, 'Tension-referenced measures of gastrocnemius slack length and stiffness in Parkinson's disease', Movement Disorders, vol. 31, pp. 1914 - 1918, http://dx.doi.org/10.1002/mds.26530
Weissleder C; Fung SJ; Wong MW; Barry G; Double KL; Halliday GM; Webster MJ; Weickert CS, 2016, 'Decline in proliferation and immature neuron markers in the human subependymal zone during aging: Relationship to EGF- and FGF-related transcripts', Frontiers in Aging Neuroscience, vol. 8, http://dx.doi.org/10.3389/fnagi.2016.00274
Davies KM; Mercer JFB; Chen N; Double KL, 2016, 'Copper dyshomoeostasis in Parkinson's disease: Implications for pathogenesis and indications for novel therapeutics', Clinical Science, vol. 130, pp. 565 - 574, http://dx.doi.org/10.1042/CS20150153
Davies KM; Hare DJ; Bohic S; James SA; Billings JL; Finkelstein DI; Doble PA; Double KL, 2015, 'Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy', Analytical Chemistry, vol. 87, pp. 6639 - 6645, http://dx.doi.org/10.1021/acs.analchem.5b01454
Todd G; Haberfield M; Faulkner PL; Hayes M; Wilcox RA; Rae C; Bulathsinhala T; Grunstein RR; Yee BJ; Double KL, 2015, 'Upper limb function is normal in patients with restless legs syndrome (Willis-Ekbom Disease)', Clinical Neurophysiology, vol. 126, pp. 736 - 742, http://dx.doi.org/10.1016/j.clinph.2014.07.010
Purves-Tyson TD; Boerrigter D; Allen K; Zavitsanou K; Karl T; Djunaidi V; Double KL; Desai R; Handelsman DJ; Weickert CS, 2015, 'Testosterone attenuates and the selective estrogen receptor modulator, raloxifene, potentiates amphetamine-induced locomotion in male rats', Hormones and Behavior, vol. 70, pp. 73 - 84, http://dx.doi.org/10.1016/j.yhbeh.2015.02.005
Schroeder RL; Double KL; Gerber JP, 2015, 'Using Sepia melanin as a PD model to describe the binding characteristics of neuromelanin - A critical review', Journal of Chemical Neuroanatomy, vol. 64-65, pp. 20 - 32, http://dx.doi.org/10.1016/j.jchemneu.2015.02.001
Todd G; Haberfield M; Faulkner PL; Rae C; Hayes M; Wilcox RA; Taylor JL; Gandevia SC; Godau J; Berg D; Piguet O; Double KL, 2014, 'Hand function is impaired in healthy older adults at risk of Parkinson’s disease', Journal of Neural Transmission, vol. 121, pp. 1377 - 1386, http://dx.doi.org/10.1007/s00702-014-1218-y
Davies KM; Bohic S; Carmona A; Ortega R; Cottam V; Hare DJ; Finberg JPM; Reyes S; Halliday GM; Mercer JFB; Double KL, 2014, 'Copper pathology in vulnerable brain regions in Parkinson's disease', Neurobiology of Aging, vol. 35, pp. 858 - 866, http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.034
Purves-Tyson TD; Owens SJ; Double KL; Desai R; Handelsman DJ; Weickert CS, 2014, 'Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0091151
Reyes S; Cottam V; Kirik D; Double KL; Halliday GM, 2013, 'Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra', Movement Disorders, vol. 28, pp. 1351 - 1359, http://dx.doi.org/10.1002/mds.25493
Dang TNT; Dobson-Stone C; Glaros EN; Kim WS; Hallupp M; Bartley L; Piguet O; Hodges JR; Halliday GM; Double KL; Schofield PR; Crouch PJ; Kwok JBJ, 2013, 'Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model', DMM Disease Models and Mechanisms, vol. 6, pp. 1198 - 1204, http://dx.doi.org/10.1242/dmm.011460
Davies KM; Hare DJ; Cottam V; Chen N; Hilgers L; Halliday GM; Mercer JFB; Double KL, 2013, 'Localization of copper and copper transporters in the human brain', Metallomics, vol. 5, pp. 43 - 51, http://dx.doi.org/10.1039/c2mt20151h
Reyes S; Fu Y; Double KL; Cottam V; Thomp LH; Kirik D; Paxinos G; Watson C; Cooper HM; Halliday GM, 2013, 'Trophic factors differentiate dopamine neurons vulnerable to Parkinson's disease', Neurobiology of Aging, vol. 34, pp. 873 - 886, http://dx.doi.org/10.1016/j.neurobiolaging.2012.07.019
Double KL, 2012, 'Neuronal vulnerability in Parkinson's disease', Parkinsonism and Related Disorders, vol. 18, http://dx.doi.org/10.1016/s1353-8020(11)70018-9
Double KL, 2012, 'Neuronal vulnerability in Parkinson's disease', Parkinsonism and Related Disorders, vol. 18, pp. 52 - 54
Chan SW; Dunlop RA; Rowe A; Double KL; Rodgers KJ, 2012, 'L-DOPA is incorporated into brain proteins of patients treated for Parkinson's disease, inducing toxicity in human neuroblastoma cells in vitro', Experimental Neurology, vol. 238, pp. 29 - 37, http://dx.doi.org/10.1016/j.expneurol.2011.09.029
Reyes S; Fu Y; Double KL; Thompson L; Kirik D; Paxinos G; Halliday GM, 2012, 'GIRK2 expression in dopamine neurons of the substantia nigra and ventral tegmental area', Journal of Comparative Neurology, vol. 520, pp. 2591 - 2607, http://dx.doi.org/10.1002/cne.23051
Purves-Tyson TD; Handelsman D; Double KL; Bustamante S; owens SJ; Shannon Weickert C, 2012, 'Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra', BMC Neuroscience, vol. 13, pp. 95, http://dx.doi.org/10.1186/1471-2202-13-95
Todd G; Taylor JL; Baumann D; Butler JE; Duman S; Hayes M; Carew-Jones F; Piguet O; Behnke S; Ridding MC; Berg D; Double KL, 2010, 'Substantia nigra echomorphology and motor cortex excitability', Neuroimage, vol. 50, pp. 1351 - 1356, http://dx.doi.org/10.1016/j.neuroimage.2010.01.088
Schofield E; Halliday GM; Kwok J; Loy C; Double KL; Hodges JR, 2010, 'Low serum progranulin predicts the presence of mutations: a prospective study', Journal of Alzheimer's Disease, vol. 22, pp. 981 - 984, http://dx.doi.org/10.3233/JAD-2010-101032
Double KL; Halliday GM; Dunkley PR; Dickson PW; Gerlach M; Riederer P, 2010, 'Pigmentation in the Human Brain and Risk of Parkinson's Disease', Annals of Neurology, vol. 67, pp. 553 - 553, http://dx.doi.org/10.1002/ana.21882
Double KL; Reyes S; Werry E; Halliday GM, 2010, 'Selective cell death in neurodegeneration: Why are some neurons spared in vulnerable regions?', Progress in Neurobiology, vol. 92, pp. 316 - 329, http://dx.doi.org/10.1016/j.pneurobio.2010.06.001
Kurz A; Double KL; Lastres-Becker I; Tozzi A; Tantucci M; Bockhart V; Bonin M; Garcia-Arencibia M; Nuber S; Schlaudraff F; Liss B; Fernandez-Ruiz J; Gerlach M; Wullner U; Luddens H; Calabresi P; Augurber G; Gispert S, 2010, 'A53T-alpha-synuclein overexpression impairs dopamine signalng and striatal synaptic plasticity in old mice', PLoS One, vol. 5, pp. e11464, http://dx.doi.org/10.1371/journal.pone.0011464
Double KL; Todd G; Duma SR, 2010, 'Pathophysiology of transcranial sonography signal changes in the human substantia nigra', International Review of Neurobiology, vol. 90, pp. 107 - 120, http://dx.doi.org/10.1016/S0074-7742(10)90008-1
Double KL; Rowe DB; Carew-Jones F; Hayes M; Chan DK; Blackie J; Corbett AJ; Joffe R; Fung VS; Morris JG; Riederer P; Gerlach M; Halliday GM, 2009, 'Anti-melanin antibodies are increased in sera in Parkinson`s disease', Experimental Neurology, vol. 217, pp. 297 - 301, http://dx.doi.org/10.1016/j.expneurol.2009.03.002
Piguet O; Double KL; Kril J; Harasty JA; Macdonald V; Mcritchie DA; Halliday GM, 2009, 'White matter loss in healthy ageing: A postmortem analysis', Neurobiology of Aging, vol. 30, pp. 1288 - 1295, http://dx.doi.org/10.1016/j.neurobiolaging.2007.10.015
Sutherland GR; Mellick GD; Newman J; Double KL; Stevens J; Lee L; Rowe DB; Silburn PA; Halliday GM, 2008, 'Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson`s disease', American Journal of Medical Genetics Part B - Neuropsychiatric Genetics, vol. 147B, pp. 495 - 499, http://dx.doi.org/10.1002/ajmg.b.30633
Gerlach M; Riederer P; Double KL, 2008, 'Neuromelanin-bound ferric iron as an experimental model of dopaminergic neurodegeneration in Parkinson`s disease', Parkinsonism and Related Disorders, vol. 14, pp. S185 - S188, http://dx.doi.org/10.1016/j.parkreldis.2008.04.028
Double KL; Dedov V; Fedorow HS; Kettle E; Halliday GM; Garner B; Brunk U, 2008, 'The comparative biology of neuromelanin and lipofuscin in the human brain', CMLS - Cellular and Molecular Life Sciences, vol. 65, pp. 1669 - 1682, http://dx.doi.org/10.1007/s00018-008-7581-9
Bohic S; Murphy KE; Paulus W; Cloetens P; Salome M; Susini J; Double KL, 2008, 'Intracellular Chemical Imaging of the Developmental Phases of Human Neuromelanin Using Synchrotron X-ray Microspectroscopy', Analytical Chemistry, vol. 80, pp. 9557 - 9566, http://dx.doi.org/10.1021/ac801817k
Dedov V; Griffiths F; Garner B; Halliday GM; Double KL, 2007, 'Lipid content determines aggregation of neuromelanin granules in vivo', Journal of Neural Transmission - Supplement, vol. 72, pp. 35 - 38, http://dx.doi.org/10.1007/978-3-211-73574-9-5
Behnke S; Double KL; Duma SR; Broe T; Guenther V; Becker GJ; Halliday GM, 2007, 'Substantia nigra echomorphology in the healthy very old: Correlation with motor slowing', Neuroimage, vol. 34, pp. 1054 - 1059, http://dx.doi.org/10.1016/j.neuroimage.2006.10.010
Tribl F; Riederer P; Double KL; Gerlach M, 2006, 'Neuromelanin, a pigment with unknown function', Neuroforum, vol. 12, pp. 190 - 196
Fedorow H; Halliday GM; Rickert CH; Gerlach M; Riederer P; Double KL, 2006, 'Evidence for specific phases in the development of human neuromelanin', Neurobiology of Aging, vol. 27, pp. 506 - 512, http://dx.doi.org/10.1016/j.neurobiolaging.2005.02.015
Tribl F; Riederer P; Double KL; Gerlach M, 2006, 'Neuromelanin, ein Pigment mit unbekannter Function', Neuroforum, vol. 2, pp. 188 - 194
Fedorow HS; Pickford R; Kettle E; Cartwright M; Halliday GM; Gerlach M; Riederer P; Garner B; Double KL, 2006, 'Investigation of the lipid component of neuromelanin', Journal of Neural Transmission, vol. 113, pp. 735 - 739, http://dx.doi.org/10.1007/s00702-006-0451-4
Halliday GM; Fedorow HS; Rickert C; Gerlach M; Riederer P; Double KL, 2006, 'Evidence for specific phases in the development of human neuromelanin', Journal of Neural Transmission, vol. 113, pp. 721 - 728, http://dx.doi.org/10.1007/s00702-006-0449-y
Double KL; Halliday GM, 2006, 'New face of neuromelanin', Journal of Neural Transmission, pp. 119 - 123
Double KL, 2006, 'Functional effects of neuromelanin and synthetic melanin in model systems', Journal of Neural Transmission, vol. 113, pp. 751 - 756, http://dx.doi.org/10.1007/s00702-006-0450-5
Youdim MB; Double KL; Gerlach M; Riederer P, 2006, 'Preface - Special Issue: Neuromelanin', Journal of Neural Transmission, vol. 113, pp. 717 - 719, http://dx.doi.org/10.1007/s00702-006-0520-8
Halliday GM; Ophof A; Broe M; Jensen PH; Kettle E; Fedorow HS; Cartwright M; Griffiths F; Shepherd CE; Double KL, 2005, 'alpha-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson`s disease', Brain, vol. 128, pp. 2654 - 2664, http://dx.doi.org/10.1093/brain/awh584
Fedorow HS; Pickford R; Hook JM; Double KL; Halliday GM; Gerlach M; Riederer P; Garner B, 2005, 'Dolichol is the major lipid component of human substantia nigra neuromelanin', Journal of Neurochemistry, vol. 92, pp. 990 - 995, http://dx.doi.org/10.1111/j.1471-4159.2004.02975.x
Li J; Scheller C; Koutsilieri E; Griffiths F; Beart PM; Mercer L; Halliday GM; Kettle E; Rowe DB; Riederer P; Gerlach M; Rodriguez M; Double KL, 2005, 'Differential effects of human neuromelanin and synthetic dopamine melanin on neuronal and glial cells', Journal of Neurochemistry, vol. 95, pp. 599 - 608, http://dx.doi.org/10.1111/j.1471-4159.2005.03404.x
Fedorow HS; Tribl F; Halliday GM; Gerlach M; Riederer P; Double KL, 2005, 'Neuromelanin in human dopamine neurons: comparison with peripheral melanins and relevance to Parkinson`s disease', Progress in Neurobiology, vol. 75, pp. 109 - 124, http://dx.doi.org/10.1016/j.pneurobio.2005.02.001
Gotz ME; Double KL; Gerlach M; Youdim MB; Riederer P, 2004, 'The relevance of iron in the pathogenesis of Parkinson`s disease', Annals of the New York Academy of Sciences, vol. 1012, pp. 193 - 208
Gerlach M; Double KL; Arzberger T; Leblhuber F; Tatschner T; Riederer P, 2003, 'Dopamine receptor agonists in current clinical use: Comparative dopamine receptor binding profiles defined in the human striatum', Journal of Neural Transmission, vol. 110, pp. 1119 - 1127
Gerlach M; Double KL; Reichmann H; Riederer P, 2003, 'Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson`s disease', Journal of Neural Transmission, vol. 65, pp. 167 - 183
Foley PB; Gerlach M; Double KL; Riederer P, 2003, 'Dopamine receptor agonists in the therapy of Parkinson`s disease', Journal of Neural Transmission, vol. 111, pp. 1375 - 1446, http://dx.doi.org/10.1007/s00702-003-0059-x
Double KL; Rowe DB; Hayes M; Chan DK; Blackie J; Corbett AJ; Joffe R; Fung VS; Morris JG; Halliday GM, 2003, 'Identifying the pattern of olfactory deficits in Parkinson disease using the brief smell identification test', Archives of Neurology, vol. 60, pp. 545 - 549, http://dx.doi.org/10.1001/archneur.60.4.545
Halliday GM; Double KL; Macdonald V; Kril J, 2003, 'Identifying severely atrophic cortical subregions in Alzheimer's disease', Neurobiology of Aging, vol. 24, pp. 797 - 806, http://dx.doi.org/10.1016/S0197-4580(02)00227-0
Gerlach M; Double KL; Ben-Shachar D; Zecca L; Youdim MB; Riederer P, 2003, 'Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson`s disease', Neurotoxicity Research, vol. 5, pp. 35 - 44, http://dx.doi.org/10.1007/BF03033371
Double KL; Halliday GM; Henderson J; Griffiths F; Heinemann T; Riederer P; Gerlach M, 2003, 'The dopamine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration', Experimental Neurology, vol. 184, pp. 530 - 535, http://dx.doi.org/10.1016/j.expneurol.2003.08.006
Double KL; Gerlach M; Schunemann V; Trautwein AX; Zecca L; Gallorini M; Youdim MB; Riederer P; Ben-Shachar D, 2003, 'Iron-binding characteristics of neuromelanin of the human substantia nigra', Biochemical Pharmacology, vol. 66, pp. 489 - 494, http://dx.doi.org/10.1016/S0006-2952(03)00293-4
Berg D; Gerlach M; Youdim MBH; Double KL; Zecca L; Riederer P; Becker G, 2002, 'Erratum: Brain iron pathways and their relevance to Parkinson's disease (Journal of Neurochemistry (79) (225-236))', Journal of Neurochemistry, vol. 80, pp. 719, http://dx.doi.org/10.1046/j.0022-3042.2001.00742.x
Double KL; Ben-Shachar D; Youdim MB; Zecca L; Riederer P; Gerlach M, 2002, 'Influence of neuromelanin on oxidative pathways within the human substantia nigra', Neurotoxicology and Teratology, vol. 24, pp. 621 - 628, http://dx.doi.org/10.1016/S0892-0362(02)00218-0
Riederer P; Reichmann H; Janetzky B; Sian J; Lesch KP; Lange KW; Double KL; Nagatsu T; Gerlach M, 2001, 'Neural degeneration in Parkinson's disease.', Advances in neurology, vol. 86, pp. 125 - 136
Berg D; Gerlach M; Youdim MB; Double KL; Zecca L; Riederer P; Becker GJ, 2001, 'Brain iron pathways and their relevance to Parkinson`s disease.', Journal of Neurochemistry, vol. 79, pp. 225 - 236, http://dx.doi.org/10.1046/j.1471-4159.2001.00608.x
Gerlach M; Double KL; Youdim MB; Riederer P, 2000, 'Strategies for the protection of dopaminergic neurons against neurotoxicity', Neurotoxicity Research, vol. 2, pp. 99 - 114
Double KL; Zecca L; Costi P; Mauer M; Griesinger C; Ito S; Ben-Shachar D; Bringmann G; Fariello RG; Riederer P; Gerlach M, 2000, 'Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins', Journal of Neurochemistry, vol. 75, pp. 2583 - 2589, http://dx.doi.org/10.1046/j.1471-4159.2000.0752583.x
Double KL; Riederer P; Gerlach M, 1999, 'Significance of neuromelanin for neurodegeneration in Parkinson's disease', Drug News and Perspectives, vol. 12, pp. 333 - 340
Double KL; Riederer P; Gerlach M, 1999, 'The significance of neuromelanin for neurodegeneration in Parkinson`s disease', Drug News and Perspectives, vol. 1, pp. 8 - 12
Double KL; Riederer P; Gerlach M, 1999, 'The role of iron in 6-hydroxydopamine neurotoxicity', Advances in Neurology, vol. 80, pp. 287 - 296
Double KL; Maywald M; Schmittel M; Riederer P; Gerlach M, 1998, 'In vitro studies of ferritin iron release and neurotoxicity', Journal of Neurochemistry, vol. 70, pp. 2492 - 2499, http://dx.doi.org/10.1046/j.1471-4159.1998.70062492.x
Halliday GM; Mcritchie DA; Macdonald V; Double KL; Trent RJ; Mccusker E, 1998, 'Regional specifity of brain atrophy in Huntington`s Disease', Experimental Neurology, vol. 154, pp. 663 - 672, http://dx.doi.org/10.1006/exnr.1998.6919
Cullen KM; Halliday GM; Double KL; Brooks WS; Creasey H; Broe GA, 1997, 'Cell loss in the nucleus basalis is related to regional cortical atrophy in Alzheimer's disease', Neuroscience, vol. 78, pp. 641 - 652, http://dx.doi.org/10.1016/S0306-4522(96)00569-6
Cullen K; Halliday GM; Double KL; Brooks WS; Creasey H; Broe T, 1997, 'Nucleus basalis cell loss is related to regional volumetric brain changes in Alzheimer's disease', Neuroscience, pp. 641 - 652
Harasty JA; Double KL; Halliday GM; Kril J; Mcritchie DA, 1997, 'Language associated cortical regions are proportionally larger in the female brain', Archives of Neurology, vol. 54, pp. 171 - 176, http://dx.doi.org/10.1001/archneur.1997.00550140045011
Double KL; Halliday GM; Mcritchie DA; Reid WG; Hely MA; Morris J, 1996, 'Regional brain atrophy in idiopathic Parkinson`s disease and diffuse Lewy body disease', Dementia, vol. 7, pp. 304 - 313, http://dx.doi.org/10.1159/000106896
Double KL; Halliday GM; Kril J; Harasty JA; Cullen K; Brooks WS; Creasey H; Broe T, 1996, 'Topography of brain atrophy during normal aging and Alzheimer's disease', Neurobiology of Aging, vol. 17, pp. 513 - 521, http://dx.doi.org/10.1016/0197-4580(96)00005-X
Lee CY; Double KL; Crocker AD, 1995, 'Expression of stereotyped behaviour requires stimulation of nigral D
Double KL; Crocker AD, 1995, 'Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, pp. 1669 - 1673, http://dx.doi.org/10.1073/pnas.92.5.1669
Double KL; Crocker AD, 1993, 'Quantitative electromyographic changes following modification of central dopaminergic transmission', Brain Research, vol. 604, pp. 342 - 344, http://dx.doi.org/10.1016/0006-8993(93)90388-4
Shiromani PJ; Overstreet DH; Lucero S; Double KL; Jeong DU, 1990, 'Dietary lithium blunts oxotremorine-induced hypothermia in a genetic animal model of depression', Lithium, vol. 1, pp. 186 - 189
Double KL; Crocker AD, 1990, 'Effects of inactivation of D
Double KL; Crocker AD, 1990, 'Effects of selective inactivation of D1 and D2 dopamine receptors on stereotypic and hypothermic responses to quinpirole (LY 171555)', European Journal of Pharmacology, vol. 183, pp. 1424 - 1425, http://dx.doi.org/10.1016/0014-2999(90)94557-E
Conference Papers
Zinger A; Double KL; Guillemin G, 2010, 'Development of an in vitro model of human dopaminergic neurons', in Small D (ed.), Australian Neurosciences Society Annual Scientific Meeting 2010, ANS, Sydney, pp. 186 - 186, presented at Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, 31 January 2010 - 03 February 2010
Bohic S; Murphy KE; Paulus W; Cloetens P; Salome M; Susini J; Double KL, 2008, 'The metallobiology of human neuromelanin during development and aging revealed using synchrotron chemical x-ray microscopy', in Proceedings of Aust Neuroscience Society, Australian Neuroscience Society 28th Annual Meeting, Hobart, pp. 115 - 115, presented at Australian Neuroscience Society 28th Annual Meeting, Hobart, 27 January 2008 - 30 January 2008
Double KL, 2006, 'Do changes in nueromelanin underlie degenerative mechanisms in the substantia nigra in Parkinson`s disease?', in Journal of Neurochemistry, Blackwell Publishing Ltd, Oxford, England, pp. 45 - 45, presented at Asian Pacific Society for Neurochemistry Meeting, Singapore, 02 July 2006 - 05 July 2006
Sutherland GT; Mellick GD; Double KL; Stevens J; Lee L; Rowe DB; Silburn PA; Halliday GM, 2006, 'An association between a tyrosine hydroxylase polymorphism and Parkinson`s disease', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 52 - 52, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006
Double KL; Halliday GM, 2006, 'Do changes in neuromelanin pigment in Parkinson`s disease provide clues to the aetiology of this disorder', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 42 - 42, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006
Murphy KE; Double KL; Halliday GM, 2006, 'Differential expression of tyrosine hydroxylase isoforms in human substantia nigra', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 51 - 51, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006
Jaeger P; Double KL, 2006, 'Neuromelanin, iron, and A-synuclein aggregation in Parkinson`s disease', in Proceedings of Aust Neuroscience Society, 26th Annual meeting of the Australian Neuroscience Society, Sydney, pp. 42 - 42, presented at 26th Annual meeting of the Australian Neuroscience Society, Sydney, 31 January 2006 - 03 February 2006
Stevens J; Sutherland GR; Lee L; Double KL; Rowe DB; Halliday GM, 2005, 'Lack of association between a functional polymorphism in the tyrosine hydroxylase gene and Parkinson`s disease', in Journal of the Neurological Sciences, Elsevier Science BV, Amsterdam, Netherlands, pp. S158 - S158, presented at XVIIIth World Congress of Neurology, Sydney, 05 November 2005 - 11 November 2005
Li J; Double KL; Gerlach M; Riederer P; Gr nblatt E, 2005, 'The main effects of neuromelanin and synthetic dopamine melanin on oxidative stress related gene expression in cell lines', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 107 - 107, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Halliday GM; Fedorow HS; Rickert C; Gerlach M; Riederer P; Double KL, 2005, 'Evidence for specific phases in the development of human neuromelanin', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 58 - 58, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Fedorow HS; Pickford R; Hook J; Double KL; Halliday GM; Gerlach M; Riederer P; Garner B, 2005, 'Dolichol is the major lipid component of neuromelanin in human substanta nigra', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 107 - 107, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Fedorow HS; Garner B; Pickford R; Hook JM; Kettle E; Cartwright HR; Double KL; Gerlach M; Riederer P; Halliday GM, 2005, 'Investigations of the lipid component of neuromelanin', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 58 - 58, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Double KL; Li J; Scheller C; Koutsilieri E; Griffiths F; Beart PM; Mercer L; Halliday GM; Kettle E; Rowe DB; Riederer P; Gerlach M; Rodriguez M, 2005, 'Functional effects of neuromelanin and synthetic melanins in model systems', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 59 - 59, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Double KL; Halliday GM, 2005, 'New face of melanin', in Parkinsonism and Related Disorders, Elsevier Sci Ltd, Kidlington, Oxford, England, pp. 65 - 65, presented at 16th International Congress on Parkinson`s Disease and Related Disorders, Berlin, Germany, 05 June 2005 - 09 June 2005
Fedorow HS; Pickford R; Hook JM; Double KL; Halliday GM; Gerlach M; Riederer P; Garner B, 2005, 'Identification of the major lipid component of neuromelanin in human dopamine neurons', in Proceedings of Aust Neuroscience Society, 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, pp. 139 - 139, presented at 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, 30 January 2005 - 02 February 2005
Griffiths F; Mercer L; Beart PM; Halliday GM; Riederer P; Gerlach M; Double KL, 2005, 'Morphological effects of neuromelanin and dopamine melanin on primary cell cultures', in Proceedings of Aust Neuroscience Society, 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, pp. 139 - 139, presented at 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, 30 January 2005 - 02 February 2005
Double KL; Li J; Scheller C; Koutsilieri E; Griffiths F; Beart PM; Mercer L; Halliday GM; Kettle E; Rowe DB; Riederer P; Gerlach M; Rodriguez M, 2005, 'Functional effects of neuromelanin on neuronal and glial cells in vitro', in Proceedings of Aust Neuroscience Society, 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, pp. 38 - 38, presented at 25th Annual Meeting of the Australian Neuroscience Society, Perth, WA, 30 January 2005 - 02 February 2005
Gerlach M; Double KL; Youdim MB; Riederer P, 2005, 'Potential sources of increased iron in the substantia nigra of parkinsonian patients', in 16th International Congress of Parkinson`s Disease and Related disorders, Berlin, Germany, pp. 133 - 142, presented at 16th International Congress of Parkinson`s Disease and Related disorders, Berlin, Germany
Potts HS; Halliday GM; Cartwright M; Rickert C; Gerlach M; Riederer P; Double KL, 2004, 'The development of nigral neuromelanin in human dopamine neurons', in Proceedings of Aust Neuroscience Society, 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, pp. 150 - 150, presented at 24th Annual Meeting of the Australian Neuroscience Society, Melbourne Convention Centre, 27 January 2004 - 30 January 2004
Double KL; Gerlach M; Schunemann V; Trautwein AX; Zecca L; Gallorini M; Youdim MB; Riederer P; Ben-Shachar D, 2003, 'Iron binding characteristics of neuromelanin of the human substantia nigra', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 904 - 0904, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003
Double KL; Halliday GM; Henderson JM; Griffiths F, 2003, 'The dopamine induced receptor lisuride attenuates iron-mediated dopaminergic neurodegeneration', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 371 - 371, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003
Ophof A; Double KL; Cartwright M; Halliday GM, 2003, 'Density of neuromelanin-pigment and pigment-associated alpha-synuclein in Parkinson`s disease', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 370 - 370, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003
Fedorow HS; Double KL; Kettle E; Cartwright M; Griffiths F; Halliday GM, 2003, 'Neuromelanin in the substantia nigra has a significant lipid component', in Proceedings of Aust Neuroscience Society, 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, pp. 381 - 381, presented at 23rd Annual Meeting of the Australian Neuroscience Society, Adelaide, Sth Aust, 28 January 2003 - 31 January 2003
Double KL; Halliday GM; Henderson JM; Griffiths F; Heinemann T; Riederer P; Gerlach M, 2002, 'The dopamine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration', in Australian Health and Medical Research Congress, Australian Health and Medical Research Congress 2002, Melbourne Convention Centre, pp. 2649 - 2649, presented at Australian Health and Medical Research Congress 2002, Melbourne Convention Centre, 24 November 2002 - 29 November 2002
Double KL; Rowe DB; Halliday GM; Riederer P; Gerlach M, 2002, 'A biochemical marker for central dopaminergic cell loss', in Movement Disorders, Wiley-Liss, Hoboken, NJ, USA, pp. 67 - 67, presented at 7th International Congress of Parkinson`s Disease and Movement Disorders Society Annual General Meeting, Miami, Florida, USA, 10 November 2002 - 14 November 2002
Double KL; Halliday GM; Rowe DB; Henderson JM; Riederer P; Gerlach M, 2002, 'The dopamine receptor agonist lisuride attenuates iron-mediated dopaminergic neurodegeneration', in Movement Disorders, Wiley-Liss, Hoboken, NJ, USA, pp. 50 - 50, presented at 7th International Congress of Parkinson`s Disease and Movement Disorders Society Annual General Meeting, Miami, Florida, USA, 10 November 2002 - 14 November 2002
Griffiths F; Double KL; Rowe DB, 2002, 'The effect of human and synthetic neuromelanin on neuronal and glial cell lines', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 133 - 133, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002
Double KL; Rowe DB; Halliday GM, 2002, 'Diagnosing preclinical Parkinson`s disease: The Sydney DEDCEL study', in Proceedings of Aust Neuroscience Society, 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, pp. 132 - 132, presented at 22nd Annual meeting of the Australian Neuroscience Society, Darling Harbour, Sydney, 04 February 2002 - 06 February 2002
Double KL; Rowe DB; Griffiths F; Chan DK; Riederer P; Gerlach M, 2001, 'A specific immune response in Parkinson`s disease indicates central dopaminergic cell death.', in Proceedings of Aust Neuroscience Society, 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, Qld, pp. 125 - 125, presented at 21st Annual Meeting of the Australian Neuroscience Society, Brisbane, Qld, 28 January 2001 - 31 January 2001
Macdonald V; Halliday GM; Mcritchie DA; Double KL; Mccusker E, 1998, 'Brain atrophy in Huntington`s disease', in Pilowsky P (ed.), 18th Annual Meeting of the Australian Neuroscience Society, 18th Annual meeting Australian Neuroscience Society, Canberra, pp. 203, presented at 18th Annual meeting Australian Neuroscience Society, Canberra, 27 January 1998 - 30 January 1998
Double KL; Halliday GM; Kril J, 1997, 'Temporal and frontal lobe atrophy characterises Alzheimer's disease', in Brain Pathology, Int Society Neuropathology, Los Angeles, CA, USA, pp. 1201 - 1201, presented at XIIIth International Congress of Neuropathology, Perth, WA, 07 September 1997 - 12 September 1997
Kril J; Halliday GM; Double KL; Harding AJ, 1997, 'Patterns of neuropathology in Alzheimer's disease and ageing', in Satellite Meeting of the 16th Congress of the International Association of Gerontology, Satellite Meeting of the 16th Congress of the International Association of Gerontology, Honolulu, Hawaii, pp. 48 - 49, presented at Satellite Meeting of the 16th Congress of the International Association of Gerontology, Honolulu, Hawaii, 16 August 1997 - 18 August 1997
Double KL; Halliday GM; Kril J, 1997, 'Temporal and frontal lobe atrophy characterises Alzheimer's disease', in Journal of Clinical Neuroscience, Churchill Livingstone, Edinburgh, Midlothian, Scotland, pp. 393 - 394, presented at Australian Association of Neurologists Annual Scientific Meeting 1997, Sydney, 30 April 1997 - 02 May 1997
Conference Posters
Gispert S; Kurz A; Double KL; Lastres-Becker I; Tozzi A; Tantucci M; Bockhart V; Bonin M; Garcia-Arencibia M; Fernandez-Ruiz J; Gerlach M; Wullner U; Luddens H; Calabresi P; Auburger G, 2010, 'A53T-alpgha-synuclein overexpression impairs dopamine signaling and striatal synaptic plastcity in old mice', in A53T-alpgha-synuclein overexpression impairs dopamine signaling and striatal synaptic plastcity in old mice, American Society for Human Genetics 60th Annual Meeting, Washington, presented at American Society for Human Genetics 60th Annual Meeting, Washington, 02 November 2010 - 06 November 2010
Stevens J; Sutherland GT; Lee LC; Double KL; Rowe DB; Halliday GM, 2005, 'Lack of association between a Functional Polymorphism in the Tyrosine Hydroxylase Gene and Parkinson`s disease', in Journal of the Neurological Sciences, Elsevier Science BV, Sydney, AUSTRALIA, Vol. 238, pp. S158 - S158, presented at 18th World Congress of Neurology, Sydney, AUSTRALIA, 05 November 2005 - 11 November 2005, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000235088001249&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Conference Presentations
Todd G; Taylor JL; Baumann D; Butler JE; Duma SR; Hayes M; Carew-Jones F; Piguet O; Behnke S; Ridding MC; Berg D; Double KL, 2010, 'Substantia nigra echomorphology and motor cortexexcitability', in Substantia nigra echomorphology and motor cortexexcitability, Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, presented at Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, 31 January 2010 - 03 February 2010
Cottam V; Halliday ; Double KL, 2010, 'Lysosomal function in Parkinson's disease', in Lysosomal function in Parkinson's disease, Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, presented at Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, 31 January 2010 - 03 February 2010
Shehadeh J; Double KL; Reyes S; Dunkley P; Halliday ; Dickson PW, 2010, 'Analysis of tyrosine hydroxylase isoforms and phosphorylation in Parkinson's disease', in Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012, Sydney, pp. 15, presented at Australian Neurosciences Society Annual Scientific Meeting 2010, Sydney, 31 January 2010 - 03 February 2010, http://dx.doi.org/10.1016/B978-0-12-800044-1.00011-8
Ng KY; Smoothy V; Dedov V; Garner B; Halliday GM; Mackay-Sim A; Sue C; Double KL, 2009, 'Decreased cholesterol in olfactory mucosa-derived cells from parkinson's disease patients with leucine-rich repeat kinase 2 mutations', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, Korea, Vol. 110, pp. 196 - 196, presented at 22nd Biennial Meeting of the ISN/APSN Joint Meeting, Korea, 23 August 2009 - 28 August 2009, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000268550400534&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
Ng KY; Smoothy V; Dedov V; Garner B; Halliday GM; Mackay-Sim A; Sue C; Double KL, 2009, 'Decreased cholesterol in olfactory mucosa-derived cells from Parkinson's disease patients with leucine-rich repeat kinase 2 mutations', in Decreased cholesterol in olfactory mucosa-derived cells from Parkinson's disease patients with leucine-rich repeat kinase 2 mutations, Paris, Paris, 07 June 2009 - 11 June 2009
Double KL, 2008, 'Brain cell death in Parkinson`s disease', in Brain cell death in Parkinson`s disease, Parkinson's Australia National Conference, Sydney, presented at Parkinson's Australia National Conference, Sydney, 16 October 2008 - 17 October 2008
Ng KY; Hayes M; Mercer S; Garner B; Halliday GM; Carew-Jones F; Double KL, 2008, 'Cholesterol in Parkinson`s disease', in Cholesterol in Parkinson`s disease, Parkinson's Australia National Conference, Sydney, presented at Parkinson's Australia National Conference, Sydney, 16 October 2008 - 17 October 2008
Conference Abstracts
Trist B; Davies KM; Cottam V; Halliday GM; Roudeau S; Carmona A; Perrin-Verdugier L; Ortega R; Double KL, 2015, 'A novel proteinaceous aggregate associated with neuronal loss in Parkinson's disease', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, Vol. 134, pp. 135 - 135, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000360206300306&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
Werry E; Enjeti S; Halliday GM; Sachdev PS; Double KL, 2011, 'Do levels of proliferation-regulating factors change with age in human adult neurogenic regions? [Abstract POS-TUE-134]', in Proceedings of the 31st ANS Annual Meeting, Australian Neuroscience Society, online, pp. 120 - 120, presented at Australian Neuroscience Society 31st Annual Meeting, Auckland, 31 January 2011 - 03 February 2011