Professor Danny Eckert | Brain Sciences UNSW

Tabs

Main

University role:

Professor

Phone:

+61 2 9399 1814

Email:

d.eckert@neura.edu.au

Dr Eckert is a sleep and respiratory physiologist. His research team based at NeuRA focuses on investigation of various aspects of sleep and upper airway physiology in humans. One of the primary goals is to investigate the multiple causes of a common sleep-related breathing disorder, obstructive sleep apnoea, to identify novel therapeutic targets and develop new individualised approaches for therapy. Multiple neurophysiological techniques to study human upper airway muscle activity, function, and airway mechanics during wakefulness and sleep are used as part of a comprehensive basic sciences and translational sleep research program. Current projects include: determining the mechanisms of upper airway muscle dysfunction in sleep apnoea, assessing the role of a variety of pharmacological agents on upper airway physiology and sleep-disordered breathing in humans, determining why people with spinal cord injury get sleep apnoea, understanding the bidirectional relationship between sleep and the brain (NeuroSleep CRE), mechanisms and new approaches to mandibular advancement therapy, and development of targeted approaches to improve sleep and breathing.

Qualifications:

BAppl Sc, BSc (Hons), PhD

Keywords:

obstructive sleep apnea

Research

Field of Research (FOR) Tag:

Respiratory Diseases

Medical Physiology

Clinical Sciences

Socio-economic Objective (SEO) tags:

Respiratory System and Diseases (incl. Asthma)

Clinical Health (Organs, Diseases and Abnormal Conditions)

Teaching & Supervision

I am available to supervise:

Yes

Areas of supervision:

A range of human physiology and clinical projects to advance knowledge in sleep apnoea pathogenesis and treatment.

Supervision keywords:

sleep

sleep apnea

sleep disorders

physiology

circulatory and respiratory physiology

respiration

breathing disorders

human experimentation

muscles

Media

Facebook:

https://www.facebook.com/NeuRASleepLab/

LinkedIn:

http://au.linkedin.com/pub/danny-eckert/b/183/ab1

Publications related to this Person

Book Chapters

Journal articles

Gouveris H; Eckert DJ, 2018, 'Editorial: Obstructive Sleep Apnea and the Brain.', Front Surg, vol. 5, pp. 78, http://dx.doi.org/10.3389/fsurg.2018.00078

Amatoury J; Jordan AS; Toson B; Nguyen C; Wellman A; Eckert DJ, 2018, 'New insights into the timing and potential mechanisms of respiratory-induced cortical arousals in obstructive sleep apnea', Sleep, vol. 41, http://dx.doi.org/10.1093/sleep/zsy160

Taranto-Montemurro L; Messineo L; Sands SA; Azarbarzin A; Marques M; Edwards BA; Eckert DJ; White DP; Wellman A, 2018, 'The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial.', Am J Respir Crit Care Med, http://dx.doi.org/10.1164/rccm.201808-1493OC

Martins RT; Carberry JC; Gandevia SC; Butler JE; Eckert DJ, 2018, 'Effects of morphine on respiratory load detection, load magnitude perception, and tactile sensation in obstructive sleep apnea', Journal of Applied Physiology, vol. 125, pp. 393 - 400, http://dx.doi.org/10.1152/japplphysiol.00065.2018

Carter SG; Carberry JC; Grunstein RR; Eckert DJ, 2018, 'Polysomnography with an epiglottic pressure catheter does not alter obstructive sleep apnea severity or sleep efficiency', Journal of Sleep Research, http://dx.doi.org/10.1111/jsr.12773

Ferreira DH; Ekström M; Sajkov D; Vandersman Z; Eckert DJ; Currow DC, 2018, 'Extended-Release Morphine for Chronic Breathlessness in Pulmonary Arterial Hypertension—A Randomized, Double-Blind, Placebo-Controlled, Crossover Study', Journal of Pain and Symptom Management, vol. 56, pp. 483 - 492, http://dx.doi.org/10.1016/j.jpainsymman.2018.07.010

Nguyen DAT; Boswell-Ruys CL; McBain RA; Eckert DJ; Gandevia SC; Butler JE; Hudson AL, 2018, 'Inspiratory pre-motor potentials during quiet breathing in ageing and chronic obstructive pulmonary disease', Journal of Physiology, vol. 596, pp. 6173 - 6189, http://dx.doi.org/10.1113/JP275764

Osman AM; Carter SG; Carberry JC; Eckert DJ, 2018, 'Obstructive sleep apnea: current perspectives', Nature and Science of Sleep, vol. 10, pp. 21 - 34, http://dx.doi.org/10.2147/NSS.S124657

Wijesuriya NS; Gainche L; Jordan AS; Berlowitz DJ; LeGuen M; Rochford PD; O'Donoghue FJ; Ruehland WR; Carberry JC; Butler JE, 2018, 'Genioglossus reflex responses to negative upper airway pressure are altered in people with tetraplegia and obstructive sleep apnoea', Journal of Physiology, vol. 596, pp. 2853 - 2864, http://dx.doi.org/10.1113/JP275222

Carberry JC; Amatoury J; Eckert DJ, 2018, 'Personalized Management Approach for OSA', Chest, vol. 153, pp. 744 - 755, http://dx.doi.org/10.1016/j.chest.2017.06.011

Hensen HA; Krishnan AV; Eckert DJ, 2018, 'Sleep-disordered breathing in people with multiple sclerosis: Prevalence, pathophysiological mechanisms, and disease consequences', Frontiers in Neurology, vol. 8, http://dx.doi.org/10.3389/fneur.2017.00740

Eckert DJ, 2018, 'Phenotypic approaches to positional therapy for obstructive sleep apnoea', Sleep Medicine Reviews, vol. 37, pp. 175 - 176, http://dx.doi.org/10.1016/j.smrv.2017.06.007

Eckert DJ, 2018, 'Phenotypic approaches to obstructive sleep apnoea – New pathways for targeted therapy', Sleep Medicine Reviews, vol. 37, pp. 45 - 59, http://dx.doi.org/10.1016/j.smrv.2016.12.003

Carberry JC; Fisher LP; Grunstein RR; Gandevia SC; McKenzie DK; Butler JE; Eckert DJ, 2017, 'Role of common hypnotics on the phenotypic causes of obstructive sleep apnoea: paradoxical effects of zolpidem', The European respiratory journal, vol. 50, http://dx.doi.org/10.1183/13993003.01344-2017

Randerath W; Verbraecken J; Andreas S; Arzt M; Bloch KE; Brack T; Buyse B; De Backer W; Eckert DJ; Grote L, 2017, 'Definition, discrimination, diagnosis and treatment of central breathing disturbances during sleep', European Respiratory Journal, vol. 49, http://dx.doi.org/10.1183/13993003.00959-2016

Landry SA; Joosten SA; Eckert DJ; Jordan AS; Sands SA; White DP; Malhotra A; Wellman A; Hamilton GS; Edwards BA, 2017, 'Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea', Sleep, vol. 40, http://dx.doi.org/10.1093/sleep/zsx056

Landry SA; Joosten SA; Eckert DJ; Jordan AS; Sands SA; White DP; Malhotra A; Wellman A; Hamilton GS; Edwards BA, 2017, 'Therapeutic CPAP Level Predicts Upper Airway Collapsibility in Patients With Obstructive Sleep Apnea', SLEEP, vol. 40, http://dx.doi.org/10.1093/sleep/zsx056

Currow D; Watts GJ; Johnson M; McDonald CF; Miners JO; Somogyi AA; Denehy L; McCaffrey N; Eckert DJ; McCloud P, 2017, 'A pragmatic, phase III, multisite, double-blind, placebo-controlled, parallel-Arm, dose increment randomised trial of regular, low-dose extended-release morphine for chronic breathlessness: Breathless', BMJ Open, vol. 7, http://dx.doi.org/10.1136/bmjopen-2017-018100

Taranto-Montemurro L; Sands SA; Azarbarzin A; Marques M; De Melo CM; Edwards BA; Eckert DJ; Messineo L; White DP; Wellman A, 2017, 'Effect of 4-aminopyridine on genioglossus muscle activity during sleep in healthy adults', Annals of the American Thoracic Society, vol. 14, pp. 1177 - 1183, http://dx.doi.org/10.1513/AnnalsATS.201701-006OC

Nguyen CD; Amatoury J; Carberry JC; Eckert DJ, 2017, 'An automated and reliable method for breath detection during variable mask pressures in awake and sleeping humans', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0179030

Taranto-Montemurro L; Sands SA; Edwards BA; Eckert DJ; White DP; Wellman A, 2017, 'Is the muscle the only potential target of desipramine in obstructive sleep apnea syndrome?: Reply', American Journal of Respiratory and Critical Care Medicine, vol. 195, pp. 1678 - 1679, http://dx.doi.org/10.1164/rccm.201701-0172LE

Arzt M; Eckert DJ, 2017, 'Is fluid overload a target to treat sleep disordered breathing in patients with end-stage renal disease, and what are the underlying mechanisms?', European Respiratory Journal, vol. 49, http://dx.doi.org/10.1183/13993003.00443-2017

Gray EL; McKenzie DK; Eckert DJ, 2017, 'Obstructive sleep apnea without obesity is common and difficult to treat: Evidence for a distinct pathophysiological phenotype', Journal of Clinical Sleep Medicine, vol. 13, pp. 81 - 88, http://dx.doi.org/10.5664/jcsm.6394

Taranto-Montemurro L; Sands SA; Edwards BA; Azarbarzin A; Marques M; De Melo C; Eckert DJ; White DP; Wellman A, 2017, 'Effects of tiagabine on slow wave sleep and arousal threshold in patients with obstructive sleep apnea', Sleep, vol. 40, http://dx.doi.org/10.1093/sleep/zsw047

Taranto-Montemurro L; Sands SA; Edwards BA; Eckert DJ; White DP; Wellman A, 2017, 'Reply: Is the Muscle the Only Potential Target of Desipramine in Obstructive Sleep Apnea Syndrome?', Am J Respir Crit Care Med, vol. 195, pp. 1678 - 1679, http://dx.doi.org/10.1164/rccm.201701-0172LE

Lin M; Krishnan AV; Eckert DJ, 2017, 'Central sleep apnea in multiple sclerosis: a pilot study', Sleep and Breathing, vol. 21, pp. 691 - 696, http://dx.doi.org/10.1007/s11325-016-1442-9

Edwards BA; Eckert DJ; Jordan AS, 2017, 'Obstructive sleep apnoea pathogenesis from mild to severe: Is it all the same?', Respirology, vol. 22, pp. 33 - 42, http://dx.doi.org/10.1111/resp.12913

Wijesuriya NS; Lewis C; Butler JE; Lee BB; Jordan AS; Berlowitz DJ; Eckert DJ, 2017, 'High nasal resistance is stable over time but poorly perceived in people with tetraplegia and obstructive sleep apnoea', Respiratory Physiology and Neurobiology, vol. 235, pp. 27 - 33, http://dx.doi.org/10.1016/j.resp.2016.09.014

Amatoury J; Azarbarzin A; Younes M; Jordan AS; Wellman A; Eckert DJ, 2016, 'Arousal intensity is a distinct pathophysiological trait in obstructive sleep apnea', Sleep, vol. 39, pp. 2091 - 2100, http://dx.doi.org/10.5665/sleep.6304

Gainche L; Berlowitz DJ; Leguen M; Ruehland WR; O'Donoghue FJ; Trinder J; Graco M; Schembri R; Eckert DJ; Rochford PD, 2016, 'Nasal Resistance Is Elevated in People with Tetraplegia and Is Reduced by Topical Sympathomimetic Administration', Journal of Clinical Sleep Medicine, vol. 12, pp. 1487 - 1492, http://dx.doi.org/10.5664/jcsm.6272

Edwards BA; Sands SA; Owens RL; Eckert DJ; Landry S; White DP; Malhotra A; Wellman A, 2016, 'The combination of supplemental oxygen and a hypnotic markedly improves obstructive sleep apnea in patients with a mild to moderate upper airway collapsibility', Sleep, vol. 39, pp. 1973 - 1983, http://dx.doi.org/10.5665/sleep.6226

Taranto-Montemurro L; Sands SA; Edwards BA; Azarbarzin A; Marques M; De Melo C; Eckert DJ; White DP; Wellman A, 2016, 'Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation', European Respiratory Journal, vol. 48, pp. 1340 - 1350, http://dx.doi.org/10.1183/13993003.00823-2016

Taranto-Montemurro L; Edwards BA; Sands SA; Marques M; Eckert DJ; White DP; Wellman A, 2016, 'Desipramine increases genioglossus activity and reduces upper airway collapsibility during non-REM sleep in healthy subjects', American Journal of Respiratory and Critical Care Medicine, vol. 194, pp. 878 - 885, http://dx.doi.org/10.1164/rccm.201511-2172OC

Martins RT; Currow DC; Abernethy AP; Johnson MJ; Toson B; Eckert DJ, 2016, 'Effects of low-dose morphine on perceived sleep quality in patients with refractory breathlessness: A hypothesis generating study', Respirology, vol. 21, pp. 386 - 391, http://dx.doi.org/10.1111/resp.12681

Martins RT; Carberry JC; Eckert DJ, 2016, 'Breath-to-breath reflex modulation of genioglossus muscle activity in obstructive sleep apnea', Sleep Medicine, vol. 21, pp. 45 - 46, http://dx.doi.org/10.1016/j.sleep.2016.02.003

Eckert DJ; Oliven A, 2016, 'When insulin has to work hard to keep the sugar at bay the upper airway collapses away', European Respiratory Journal, vol. 47, pp. 1611 - 1614, http://dx.doi.org/10.1183/13993003.00590-2016

Carter SG; Berger MS; Carberry JC; Bilston LE; Butler JE; Tong BKY; Martins RT; Fisher LP; McKenzie DK; Grunstein RR, 2016, 'Zopiclone increases the arousal threshold without impairing genioglossus activity in obstructive sleep apnea', Sleep, vol. 39, pp. 757 - 766, http://dx.doi.org/10.5665/sleep.5622

Nguyen CD; Wellman A; Jordan AS; Eckert DJ, 2016, 'Mild airflow limitation during N2 sleep increases K-complex frequency and slows electroencephalographic activity', Sleep, vol. 39, pp. 541 - 550, http://dx.doi.org/10.5665/sleep.5522

Carberry JC; Jordan AS; White DP; Wellman A; Eckert DJ, 2016, 'Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent', Sleep, vol. 39, pp. 511 - 521, http://dx.doi.org/10.5665/sleep.5516

Terrill PI; Edwards BA; Nemati S; Butler JP; Owens RL; Eckert DJ; White DP; Malhotra A; Wellman A; Sands SA, 2015, 'Quantifying the ventilatory control contribution to sleep apnoea using polysomnography', European Respiratory Journal, vol. 45, pp. 408 - 418, http://dx.doi.org/10.1183/09031936.00062914

Carberry JC; Hensen H; Fisher LP; Saboisky JP; Butler JE; Gandevia SC; Eckert DJ, 2015, 'Mechanisms contributing to the response of upper-airway muscles to changes in airway pressure', Journal of Applied Physiology, vol. 118, pp. 1221 - 1228, http://dx.doi.org/10.1152/japplphysiol.01103.2014

Owens RL; Edwards BA; Eckert DJ; Jordan AS; Sands SA; Malhotra A; White DP; Loring SH; Butler JP; Wellman A, 2015, 'An integrative model of physiological traits can be used to predict obstructive sleep apnea and response to non positive airway pressure therapy', Sleep, vol. 38, pp. 961 - 970, http://dx.doi.org/10.5665/sleep.4750

Jordan AS; Cori JM; Dawson A; Nicholas CL; O'Donoghue FJ; Catcheside PG; Eckert DJ; McEvoy RD; Trinder J, 2015, 'Arousal from sleep does not lead to reduced dilator muscle activity or elevated upper airway resistance on return to sleep in healthy individuals', Sleep, vol. 38, pp. 53 - 59, http://dx.doi.org/10.5665/sleep.4324

Sands SA; Eckert DJ; Jordan AS; Edwards BA; Owens RL; Butler JP; Schwab RJ; Loring SH; Malhotra A; White DP, 2014, 'Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 190, pp. 930 - 937, http://dx.doi.org/10.1164/rccm.201404-0783OC

Edwards BA; Eckert DJ; McSharry DG; Sands SA; Desai A; Kehlmann G; Bakker JP; Genta PR; Owens RL; White DP, 2014, 'Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 190, pp. 1293 - 1300, http://dx.doi.org/10.1164/rccm.201404-0718OC

Genta PR; Schorr F; Eckert DJ; Gebrim E; Kayamori F; Moriya HT; Malhotra A; Lorenzi-Filho G, 2014, 'Upper airway collapsibility is associated with obesity and hyoid position.', Sleep, vol. 37, pp. 1673 - 1678, http://dx.doi.org/10.5665/sleep.4078

Genta PR; Owens RL; Edwards BA; Sands SA; Eckert DJ; Butler JP; Loring SH; Malhotra A; Jackson AC; White DP, 2014, 'Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway', Respiratory Physiology and Neurobiology, vol. 201, pp. 55 - 59, http://dx.doi.org/10.1016/j.resp.2014.07.005

Edwards BA; Wellman A; Sands SA; Owens RL; Eckert DJ; White DP; Malhotra A, 2014, 'Obstructive sleep apnea in older adults is a distinctly different physiological phenotype.', Sleep, vol. 37, pp. 1227 - 1236, http://dx.doi.org/10.5665/sleep.3844

Owens RL; Edwards BA; Sands SA; Butler JP; Eckert DJ; White DP; Malhotra A; Wellman A, 2014, 'The classical Starling resistor model often does not predict inspiratory airflow patterns in the human upper airway', Journal of Applied Physiology, vol. 116, pp. 1105 - 1112, http://dx.doi.org/10.1152/japplphysiol.00853.2013

Teodorescu M; Xie A; Sorkness CA; Robbins J; Reeder S; Gong Y; Fedie JE; Sexton A; Miller B; Huard T, 2014, 'Effects of Inhaled Fluticasone on Upper Airway during Sleep and Wakefulness in Asthma: A Pilot Study', Journal of Clinical Sleep Medicine, vol. 10, pp. 183 - 193D, http://dx.doi.org/10.5664/jcsm.3450

Martins RT; Eckert DJ, 2014, 'Central Sleep Apnea due to Other Medical Disorders', Sleep Medicine Clinics, vol. 9, pp. 57 - 67, http://dx.doi.org/10.1016/j.jsmc.2013.10.002

Eckert DJ; Malhotra A; Wellman A; White DP, 2014, 'Trazodone Increases the Respiratory Arousal Threshold in Obstructive Sleep Apnea Patients with a Low Arousal Threshold', Sleep, vol. 37, pp. 811 - 819, http://dx.doi.org/10.5665/sleep.3596

Eckert DJ; Gandevia SC, 2014, 'The human upper airway: More than a floppy tube', Journal of Applied Physiology, vol. 116, pp. 288 - 290, http://dx.doi.org/10.1152/japplphysiol.01326.2013

Eckert DJ; Younes MK, 2014, 'Arousal from sleep: Implications for obstructive sleep apnea pathogenesis and treatment', Journal of Applied Physiology, vol. 116, pp. 302 - 313, http://dx.doi.org/10.1152/japplphysiol.00649.2013

Eckert DJ; White DP; Jordan AS; Malhotra A; Wellman A, 2014, 'Reply: Arousal threshold in obstructive sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 189, pp. 373 - 374, http://dx.doi.org/10.1164/rccm.201312-2115LE

Wang D; Eckert DJ; Grunstein RR, 2013, 'Drug effects on ventilatory control and upper airway physiology related to sleep apnea.', Respir Physiol Neurobiol, vol. 188, pp. 257 - 266, http://dx.doi.org/10.1016/j.resp.2013.05.007

Eckert DJ; White DP; Jordan AS; Malhotra A; Wellman A, 2013, 'Defining phenotypic causes of obstructive sleep apnea: Identification of novel therapeutic targets', American Journal of Respiratory and Critical Care Medicine, vol. 188, pp. 996 - 1004, http://dx.doi.org/10.1164/rccm.201303-0448OC

Edwards BA; Sands SA; Eckert DJ; White DP; Butler JP; Owens RL; Malhotra A; Wellman A, 2012, 'Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea', Journal of Physiology, vol. 590, pp. 1199 - 1211, http://dx.doi.org/10.1113/jphysiol.2011.223925

Owens RL; Edwards BA; Sands SA; Butler JP; Eckert DJ; White DP; Malhotra A; Wellman A, 2012, 'Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume', Journal of Applied Physiology, vol. 113, pp. 691 - 699, http://dx.doi.org/10.1152/japplphysiol.00091.2012

Owens RL; Campana LM; Hess L; Eckert DJ; Loring SH; Malhotra A, 2012, 'Sitting and supine esophageal pressures in overweight and obese subjects', Obesity, vol. 20, pp. 2354 - 2360, http://dx.doi.org/10.1038/oby.2012.120

Saboisky JP; Stashuk DW; Hamilton-Wright A; Carusona AL; Campana LM; Trinder J; Eckert DJ; Jordan AS; McSharry DG; White DP, 2012, 'Neurogenic changes in the upper airway of patients with obstructive sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 185, pp. 322 - 329, http://dx.doi.org/10.1164/rccm.201106-1058OC

Nicholas CL; Jordan AS; Heckel L; Worsnop C; Bei B; Saboisky JP; Eckert DJ; White DP; Malhotra A; Trinder J, 2012, 'Discharge patterns of human tensor palatini motor units during sleep onset', Sleep, vol. 35, pp. 699 - 707, http://dx.doi.org/10.5665/sleep.1834

Saboisky JP; Butler JE; Gandevia SC; Eckert DJ, 2012, 'Functional role of neural injury in obstructive sleep apnea', Frontiers in Neurology, vol. JUN, http://dx.doi.org/10.3389/fneur.2012.00095

Eckert DJ; Owens RL; Kehlmann GB; Wellman A; Rahangdale S; Yim-Yeh S; White DP; Malhotra A, 2011, 'Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold', Clinical Science, vol. 120, pp. 505 - 514, http://dx.doi.org/10.1042/CS20100588

Wellman A; Eckert DJ; Jordan AS; Edwards BA; Passaglia CL; Jackson AC; Gautam S; Owens RL; Malhotra A; White DP, 2011, 'A method for measuring and modeling the physiological traits causing obstructive sleep apnea', Journal of Applied Physiology, vol. 110, pp. 1627 - 1637, http://dx.doi.org/10.1152/japplphysiol.00972.2010

Eastwood PR; Barnes M; Walsh JH; Maddison KJ; Hee G; Schwartz AR; Smith PL; Malhotra A; McEvoy RD; Wheatley JR, 2011, 'Treating obstructive sleep apnea with hypoglossal nerve stimulation', Sleep, vol. 34, pp. 1479 - 1486, http://dx.doi.org/10.5665/sleep.1380

Genta PR; Eckert DJ; Gregorio MG; Danzi NJ; Moriya HT; Malhotra A; Lorenzi-Filho G, 2011, 'Critical closing pressure during midazolam-induced sleep', Journal of Applied Physiology, vol. 111, pp. 1315 - 1322, http://dx.doi.org/10.1152/japplphysiol.00508.2011

Jordan AS; Eckert DJ; Wellman A; Trinder JA; Malhotra A; White DP, 2011, 'Termination of respiratory events with and without cortical arousal in obstructive sleep apnea', American Journal of Respiratory and Critical Care Medicine, vol. 184, pp. 1183 - 1191, http://dx.doi.org/10.1164/rccm.201106-0975OC

Jordan AS; Saboisky JP; Nicholas CL; Bei B; Eckert DJ, 2011, 'Common drive in hypoglossal and trigeminal motor neurons', American Journal of Respiratory and Critical Care Medicine, vol. 183, pp. 1280, http://dx.doi.org/10.1164/rccm.201009-1511IM

Eckert DJ; Lo YL; Saboisky JP; Jordan AS; White DP; Malhotra A, 2011, 'Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea', Journal of Applied Physiology, vol. 111, pp. 1644 - 1653, http://dx.doi.org/10.1152/japplphysiol.00653.2011

Saboisky J; Eckert D; Malhotra A, 2010, 'Stable breathing through deeper sleeping', Thorax, vol. 65, pp. 95 - 96, http://dx.doi.org/10.1136/thx.2009.127860

Campana L; Eckert DJ; Patel SR; Malhotra A, 2010, 'Pathophysiology & genetics of obstructive sleep apnoea', Indian Journal of Medical Research, vol. 131, pp. 176 - 187

Owens RL; Malhotra A; Eckert DJ; White DP; Jordan AS, 2010, 'The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility', Journal of Applied Physiology, vol. 108, pp. 445 - 451, http://dx.doi.org/10.1152/japplphysiol.00755.2009

Jordan AS; White DP; Owens RL; Eckert DJ; Rahangdale S; Yim-Yeh S; Malhotra A, 2010, 'The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse', Journal of Applied Physiology, vol. 109, pp. 469 - 475, http://dx.doi.org/10.1152/japplphysiol.00373.2010

Eikermann M; Eckert DJ; Chamberlin NL; Jordan AS; Zaremba S; Smith S; Rosow C; Malhotra A, 2010, 'Effects of pentobarbital on upper airway patency during sleep', European Respiratory Journal, vol. 36, pp. 569 - 576, http://dx.doi.org/10.1183/09031936.00153809

Eckert DJ; Elgar NJ; McEvoy RD; Catcheside PG, 2010, 'Alcohol alters sensory processing to respiratory stimuli in healthy men and women during wakefulness', Sleep, vol. 33, pp. 1389 - 1395, http://dx.doi.org/10.1093/sleep/33.10.1389

Eckert DJ; Saboisky JP; Jordan AS; White DP; Malhotra A, 2010, 'A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure', Journal of Applied Physiology, vol. 108, pp. 1619 - 1624, http://dx.doi.org/10.1152/japplphysiol.01437.2009

Saboisky JP; Jordan AS; Eckert DJ; White DP; Trinder JA; Nicholas CL; Gautam S; Malhotra A, 2010, 'Recruitment and rate-coding strategies of the human genioglossus muscle', Journal of Applied Physiology, vol. 109, pp. 1939 - 1949, http://dx.doi.org/10.1152/japplphysiol.00812.2010

Eckert DJ; Malhotra A; Jordan AS, 2009, 'Mechanisms of Apnea', Progress in Cardiovascular Diseases, vol. 51, pp. 313 - 323, http://dx.doi.org/10.1016/j.pcad.2008.02.003

Jordan AS; Whit DP; Lo YL; Wellman A; Eckert DJ; Yim-Yeh S; Eikermann M; Smith SA; Stevenson KE; Malhotra A, 2009, 'Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea', Sleep, vol. 32, pp. 361 - 368, http://dx.doi.org/10.1093/sleep/32.3.361

Eckert DJ; Malhotra A; Lo YL; White DP; Jordan AS, 2009, 'The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep', Chest, vol. 135, pp. 957 - 964, http://dx.doi.org/10.1378/chest.08-2292

Eckert DJ; Malhotra A, 2008, 'Pathophysiology of adult obstructive sleep apnea', Proceedings of the American Thoracic Society, vol. 5, pp. 144 - 153, http://dx.doi.org/10.1513/pats.200707-114MG

Eckert DJ; McEvoy RD; George KE; Thomson KJ; Catcheside PG, 2008, 'Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men', Journal of Applied Physiology, vol. 104, pp. 1426 - 1435, http://dx.doi.org/10.1152/japplphysiol.01056.2007

Owens RL; Eckert DJ; Yeh SY; Malhotra A, 2008, 'Upper airway function in the pathogenesis of obstructive sleep apnea: A review of the current literature', Current Opinion in Pulmonary Medicine, vol. 14, pp. 519 - 524, http://dx.doi.org/10.1097/MCP.0b013e3283130f66

Eckert DJ; Jordan AS; Merchia P; Malhotra A, 2007, 'Central sleep apnea: Pathophysiology and treatment', Chest, vol. 131, pp. 595 - 607, http://dx.doi.org/10.1378/chest.06.2287

Nalivaiko E; Catcheside PG; Adams A; Jordan AS; Eckert DJ; McEvoy RD, 2007, 'Cardiac changes during arousals from non-REM sleep in healthy volunteers', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 292, http://dx.doi.org/10.1152/ajpregu.00642.2006

Eckert DJ; McEvoy RD; George KE; Thomson KJ; Catcheside PG, 2007, 'Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males', Journal of Physiology, vol. 581, pp. 1193 - 1205, http://dx.doi.org/10.1113/jphysiol.2007.132332

Hlavac MC; Catcheside PG; Adams A; Eckert DJ; McEvoy RD, 2007, 'The effects of hypoxia on load compensation during sustained incremental resistive loading in patients with obstructive sleep apnea', Journal of Applied Physiology, vol. 103, pp. 234 - 239, http://dx.doi.org/10.1152/japplphysiol.01618.2005

Eckert DJ; Saboisky JP; Jordan AS; Malhotra A, 2007, 'Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea', Journal of Clinical Sleep Medicine, vol. 3, pp. 570 - 573

Eckert DJ; Catcheside PG; Stadler DL; McDonald R; Hlavac MC; McEvoy RD, 2006, 'Acute sustained hypoxia suppresses the cough reflex in healthy subjects', American Journal of Respiratory and Critical Care Medicine, vol. 173, pp. 506 - 511, http://dx.doi.org/10.1164/rccm.200509-1455OC

Hlavac MC; Catcheside PG; McDonald R; Eckert DJ; Windler S; McEvoy RD, 2006, 'Hypoxia impairs the arousal response to external resistive loading and airway occlusion during sleep', Sleep, vol. 29, pp. 624 - 631

Eckert DJ; Catcheside PG; McDonald R; Adams AM; Webster KE; Hlavac MC; McEvoy RD, 2005, 'Sustained hypoxia depresses sensory processing of respiratory resistive loads', American Journal of Respiratory and Critical Care Medicine, vol. 172, pp. 1047 - 1054, http://dx.doi.org/10.1164/rccm.200505-699OC

Eckert DJ; Catcheside PG; Smith JH; Frith PA; Doug McEvoy R, 2004, 'Hypoxia suppresses symptom perception in asthma', American Journal of Respiratory and Critical Care Medicine, vol. 169, pp. 1224 - 1230

Eckert DJ; Catcheside PG; McEvoy RD, 2004, 'Blunted sensation of dyspnoea and near fatal asthma', European Respiratory Journal, vol. 24, pp. 197 - 199, http://dx.doi.org/10.1183/09031936.04.00052704

O'Donoghue FJ; Catcheside PG; Eckert DJ; McEvoy RD, 2004, 'Changes in respiration in NREM sleep in hypercapnic chronic obstructive pulmonary disease', Journal of Physiology, vol. 559, pp. 663 - 673, http://dx.doi.org/10.1113/jphysiol.2004.066084

Jordan AS; Eckert DJ; Catcheside PG; McEvoy RD, 2003, 'Ventilatory Response to Brief Arousal from Non-Rapid Eye Movement Sleep Is Greater in Men Than in Women', American Journal of Respiratory and Critical Care Medicine, vol. 168, pp. 1512 - 1519, http://dx.doi.org/10.1164/rccm.200302-150OC

Conference Papers

Martins RT; Carberry J; Wang D; Rowsell L; Grunstein R; Eckert DJ, 2017, 'EFFECTS OF MORPHINE ON THE PHENOTYPIC CAUSES OF OBSTRUCTIVE SLEEP APNEA', in SLEEP MEDICINE, ELSEVIER SCIENCE BV, pp. E329 - E329, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000444558903478&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Tong B; Amatoury J; Carberry J; Eckert D, 2017, 'THE EFFECTS OF POSTURE AND MANDIBULAR ADVANCEMENT ON NASAL RESISTANCE AND OBSTRUCTIVE SLEEP APNEA TREATMENT OUTCOME WITH A NOVEL ORAL APPLIANCE THERAPY DEVICE', in SLEEP MEDICINE, ELSEVIER SCIENCE BV, pp. E87 - E87, http://dx.doi.org/10.1016/j.sleep.2017.11.249

Conference Abstracts

Tong B; Tran C; Ricciardiello A; Donegan M; Murray N; Chiang A; Amatoury J; Eckert D, 2018, 'Combined CPAP and oral appliance (OA) therapy reduces PAP requirements and pharyngeal pressure (Pepi) swings in OSA', in EUROPEAN RESPIRATORY JOURNAL, EUROPEAN RESPIRATORY SOC JOURNALS LTD, Paris, FRANCE, Vol. 52, presented at 28th International Congress of the European-Respiratory-Society (ERS), Paris, FRANCE, 15 - 19 September 2018, http://dx.doi.org/10.1183/13993003.congress-2018.PA4346

Tong B; Tran C; Ricciardiello A; Donegan M; Murray N; Chiang A; Amatoury J; Eckert D, 2018, 'Postural effects on nasal resistance in obstructive sleep apnoea (OSA) and efficacy of a novel oral appliance', in EUROPEAN RESPIRATORY JOURNAL, EUROPEAN RESPIRATORY SOC JOURNALS LTD, Paris, FRANCE, Vol. 52, presented at 28th International Congress of the European-Respiratory-Society (ERS), Paris, FRANCE, 15 - 19 September 2018, http://dx.doi.org/10.1183/13993003.congress-2018.PA4339

Osman AM; Carberry J; Burke P; Tong B; Grunstein RR; Eckert DJ, 2018, 'A Simple Wakefulness Upper Airway Collapsibility Test Closely Relates to the Pharyngeal Critical Closing Pressure (PCRIT) During Sleep in Obstructive Sleep Apnea', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, San Diego, CA, Vol. 197, presented at International Conference of the American-Thoracic-Society, San Diego, CA, 18 - 23 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449978900244&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Osman AM; Butler J; Chiang A; Gandevia SC; Eckert DJ, 2018, 'The Pharyngeal Airway Is Most Collapsible During Mid-Expiration in Obstructive Sleep Apnea', in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, AMER THORACIC SOC, San Diego, CA, Vol. 197, presented at International Conference of the American-Thoracic-Society, San Diego, CA, 18 - 23 May 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449978900248&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Osman' A; Butler J; Gandevia S; Eckert D, 2018, 'The upper airway is most collapsible during expiration in obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, Brisbane, AUSTRALIA, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), Brisbane, AUSTRALIA, 17 - 20 October 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100125&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Burke P; Knapman F; Tong B; Brown E; Sutherland K; Cistulli P; Juge L; Butler J; Eckert D; Bilston L, 2018, 'Effects of Mandibular Advancement Splints on upper airway physiology in obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, Brisbane, AUSTRALIA, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), Brisbane, AUSTRALIA, 17 - 20 October 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100039&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Juge L; Knapman F; Eckert D; Burke P; Brown E; Butler J; Ngiam J; Sutherland K; Cistulli P; Bilston L, 2018, 'Tongue deformation during mandibular advancement may help to predict mandibular advancement treatment outcome in obese patients with obstructive sleep apnoea', in JOURNAL OF SLEEP RESEARCH, WILEY, Brisbane, AUSTRALIA, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), Brisbane, AUSTRALIA, 17 - 20 October 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100156&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Kalucy M; Foung H; O'Donnell M; Ward P; Barclay M; Curtis J; Morrell R; Eckert D; Murray N; Omana C, 2018, 'Screening for obstructive sleep apnoea in the clozapine clinic - prevalence of 'high risk' and feasibility of screening', in JOURNAL OF SLEEP RESEARCH, WILEY, Brisbane, AUSTRALIA, Vol. 27, presented at 30th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and the Australasian-Sleep-Technologists-Association (Sleep DownUnder), Brisbane, AUSTRALIA, 17 - 20 October 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446452100045&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Eckert DJ, 2018, 'Pathophysiological phenotyping as a rational for drug development', in JOURNAL OF SLEEP RESEARCH, WILEY, Basel, SWITZERLAND, Vol. 27, presented at 24th Congress of the European-Sleep-Research-Society (ESRS), Basel, SWITZERLAND, 25 - 28 September 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000444228300147&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Zheng Y; Burke P; Knapman F; Brown E; Eckert D; Butler J; Bilston L, 2017, 'REGIONAL NEURAL CONTROL OF GENIOGLOSSUS IN WAKE AND SLEEP', in RESPIROLOGY, WILEY, Vol. 22, pp. 38 - 38, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415925700090&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Martins RT; Carberry J; Wang D; Rowsell L; Grunstein R; Mckenzie D; Eckert D, 2017, 'FFECTS OF 40 MG OF MORPHINE ON PHENOTYPIC CAUSES OF OBSTRUCTIVE SLEEP APNEA', in JOURNAL OF SLEEP RESEARCH, WILEY, Auckland, NEW ZEALAND, Vol. 26, pp. 7 - 7, presented at 29th Annual Scientific Meeting (ASM) of Australasian-Sleep-Association and Australasian-Sleep-Technologists-Association, Auckland, NEW ZEALAND, 25 - 28 October 2017, http://dx.doi.org/10.1111/jsr.5_12618

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